{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:17:30Z","timestamp":1784297850333,"version":"3.55.0"},"reference-count":35,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2015,6,21]]},"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Gastric atrophy and intestinal metaplasia (IM) are preneoplastic conditions in the development of gastric cancer. Histopathological assessment is based on the updated Sydney system and superordinate staging systems, operative link on gastritis assessment (OLGA) and operative link on gastritis assessment using IM (OLGIM), all requiring a biopsy from the\n                      <jats:italic>incisura angularis<\/jats:italic>\n                      (angulus).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine the value of the angulus biopsy for the detection of preneoplastic conditions and cancer risk evaluation using OLGA and OLGIM prospectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Biopsies from antrum (2), angulus (1) and corpus (2) were obtained from 213 patients (age 19\u201394\u2005years, median 54\u2005years, female to male ratio 138:75) undergoing upper endoscopy. Histological assessment according to the updated Sydney system, OLGA and OLGIM staging was performed by gastrointestinal pathologists. Statistical analysis used exact confidence limits for dichotomous variables and repeated measurement analysis of variance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>8% of the cases with atrophic gastritis and 3% with IM (17 vs 6\/213) would have been missed without the angulus biopsy. More patients were diagnosed with a preneoplastic condition when the angulus biopsy was considered (13.1%, CI 8.9% to 18.4%), but the grade of atrophy, if present at both sides, did not vary significantly in angulus and antrum. OLGA and OLGIM scores dropped significantly when recalculated without the angulus (difference in means\u00b1SD 0.131\u00b10.402 and 0.075\u00b10.313, respectively). The impact on the identification of high-risk stages is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The angulus biopsy adds to the detection of mild gastric atrophy in particular. It allows identifying a small additional number of patients with high-risk gastritis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2015-202858","type":"journal-article","created":{"date-parts":[[2015,7,10]],"date-time":"2015-07-10T22:45:08Z","timestamp":1436568308000},"page":"19-25","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":35,"title":["Impact of the angulus biopsy for the detection of gastric preneoplastic conditions and gastric cancer risk assessment"],"prefix":"10.1136","volume":"69","author":[{"given":"M","family":"Varbanova","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University of Magdeburg, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Wex","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University of Magdeburg, Magdeburg, Germany"},{"name":"Department Molecular Genetics, Medical Laboratories for Clinical Chemistry, Microbiology and Infectious Diseases, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Jechorek","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Otto-von-Guericke-University of Magdeburg, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FW","family":"R\u00f6hl","sequence":"additional","affiliation":[{"name":"Institute of Biometrics and Medical Informatics, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Langner","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University of Magdeburg, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Selgrad","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University of Magdeburg, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Malfertheiner","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University of Magdeburg, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,7,10]]},"reference":[{"key":"2025112110180053000_69.1.19.1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.01.071"},{"key":"2025112110180053000_69.1.19.2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"2025112110180053000_69.1.19.3","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.106666"},{"key":"2025112110180053000_69.1.19.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2009.12.029"},{"key":"2025112110180053000_69.1.19.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06767.x"},{"key":"2025112110180053000_69.1.19.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"2025112110180053000_69.1.19.7","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1111\/j.1365-2036.2010.04268.x","article-title":"Risk factors for progression to gastric neoplastic lesions in patients with atrophic gastritis","volume":"31","author":"Vannella","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"2025112110180053000_69.1.19.8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1055\/s-0028-1098086","article-title":"An endoscopic recognition of the atrophic border and its significance in chronic gastritis","volume":"1","author":"Kimura","year":"1969","journal-title":"Endoscopy"},{"key":"2025112110180053000_69.1.19.9","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1111\/j.1365-2036.2010.04277.x","article-title":"Gastritis OLGA-staging and gastric cancer risk: a twelve-year clinico-pathological follow-up study","volume":"31","author":"Rugge","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"2025112110180053000_69.1.19.10","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1326379"},{"key":"2025112110180053000_69.1.19.11","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1291491"},{"key":"2025112110180053000_69.1.19.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2008.02.030"},{"key":"2025112110180053000_69.1.19.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2007.12.012"},{"key":"2025112110180053000_69.1.19.14","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181a3d5f4"},{"key":"2025112110180053000_69.1.19.15","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25476"},{"key":"2025112110180053000_69.1.19.16","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940715)74:2<556::AID-CNCR2820740205>3.0.CO;2-J"},{"key":"2025112110180053000_69.1.19.17","doi-asserted-by":"publisher","DOI":"10.1002\/mc.2940110102"},{"key":"2025112110180053000_69.1.19.18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2010.00760.x"},{"key":"2025112110180053000_69.1.19.19","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2003.3"},{"key":"2025112110180053000_69.1.19.20","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.026310"},{"key":"2025112110180053000_69.1.19.21","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.9.1387"},{"key":"2025112110180053000_69.1.19.22","first-page":"1317","article-title":"Precancerous gastric lesions in a population at high risk of stomach cancer","volume":"53","author":"You","year":"1993","journal-title":"Cancer Res"},{"key":"2025112110180053000_69.1.19.23","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000082"},{"key":"2025112110180053000_69.1.19.24","doi-asserted-by":"publisher","DOI":"10.1086\/345374"},{"key":"2025112110180053000_69.1.19.25","first-page":"1732","article-title":"Evaluation of optimal gastric mucosal biopsy site and number for identification of Helicobacter pylori, gastric atrophy and intestinal metaplasia","volume":"51","author":"Dursun","year":"2004","journal-title":"Hepatogastroenterology"},{"key":"2025112110180053000_69.1.19.26","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90303-9"},{"key":"2025112110180053000_69.1.19.27","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-861311"},{"key":"2025112110180053000_69.1.19.28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.166_b.x"},{"key":"2025112110180053000_69.1.19.29","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i41.4596"},{"key":"2025112110180053000_69.1.19.30","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-12-182"},{"key":"2025112110180053000_69.1.19.31","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302084"},{"key":"2025112110180053000_69.1.19.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2008.08.041"},{"key":"2025112110180053000_69.1.19.33","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2431-x"},{"key":"2025112110180053000_69.1.19.34","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12383"},{"key":"2025112110180053000_69.1.19.35","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90133-8"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2015-202858","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:18:07Z","timestamp":1763749087000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2015-202858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,10]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,12,15]]},"published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1136\/jclinpath-2015-202858"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2015-202858","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,10]]}}}