{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:40:52Z","timestamp":1763750452339,"version":"3.45.0"},"reference-count":34,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2015,6,11]]},"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Liver fibrosis and cirrhosis may be reversible in some circumstances. Reliable diagnostic tests are necessary for monitoring hepatic fibrogenesis. Matrix metalloproteinase (MMP)-2 and MMP-9 are two of the major MMPs in the circulation and may be most relevant to hepatic fibrosis. The behaviour of MMPs may be significantly different in men and women and may also differ in cases of cirrhosis of various aetiologies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the manifestations of MMP-2 and MMP-9 in liver cirrhosis of different aetiologies in men and women and to compare these patterns with those of healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We measured MMP-2 and MMP-9 levels in plasma samples from 112 patients with cirrhosis and 112 age- and gender-matched healthy controls. We then correlated these MMP levels with gender and disease aetiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Plasma MMP-2 concentrations in patients showed a trend towards increasing values with cirrhosis severity and were markedly increased in patients regardless of gender and aetiology compared with healthy controls (p&lt;0.0001). Plasma mean MMP-9 levels were comparable in patients with cirrhosis and controls, but increased with disease severity. They were significantly lower in patients (130.5 ng\/mL), female patients (85.4 ng\/mL) and male patients (150.4 ng\/mL) with mild cirrhosis than in controls (163.2 ng\/mL), female controls (162.5 ng\/mL) and male controls (163.3 ng\/mL) (p=0.001, 0.041 and 0.009, respectively). MMP-2 and MMP-9 concentrations were not significantly different between genders among controls and among various patient subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Plasma MMP-2 level may be a useful diagnostic marker for monitoring hepatic fibrogenesis in patients with disease of different aetiologies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2015-202932","type":"journal-article","created":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T22:29:18Z","timestamp":1438813758000},"page":"917-922","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Plasma levels of matrix metalloproteinase-2 and -9 in male and female patients with cirrhosis of different aetiologies"],"prefix":"10.1136","volume":"68","author":[{"given":"Chih-Yang","family":"Huang","sequence":"first","affiliation":[{"name":"Graduate Institutes of Basic and Chinese Medical Sciences, China Medical University, Taichung, Taiwan"},{"name":"Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo-Chih","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Buddhist Dalin Tzu Chi Hospital, Chiayi, Taiwan"},{"name":"School of Medicine, Tzu Chi University, Hualien, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Nan","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Medicine, Tzu Chi University, Hualien, Taiwan"},{"name":"Department of Family Medicine, Buddhist Dalin Tzu Chi Hospital, Chiayi, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jen-Pi","family":"Tsai","sequence":"additional","affiliation":[{"name":"School of Medicine, Tzu Chi University, Hualien, Taiwan"},{"name":"Department of Nephrology, Buddhist Dalin Tzu Chi Hospital, Chiayi, Taiwan"},{"name":"Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Chuan","family":"Su","sequence":"additional","affiliation":[{"name":"Departments of Clinical Pathology and Anatomic Pathology, Buddhist Dalin Tzu Chi Hospital, Chiayi, Taiwan"},{"name":"Departments of Laboratory Medicine and Pathology, School of Medicine, Tzu Chi University, Hualien, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,8,5]]},"reference":[{"key":"2025112110370022000_68.11.917.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(11)80985-4"},{"key":"2025112110370022000_68.11.917.2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.1999.01928.x"},{"key":"2025112110370022000_68.11.917.3","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(95)80258-4"},{"key":"2025112110370022000_68.11.917.4","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/hep.510260440","article-title":"Matrix degradation in liver: a role in injury and repair","volume":"26","author":"Arthur","year":"1997","journal-title":"Hepatology"},{"key":"2025112110370022000_68.11.917.5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1018"},{"key":"2025112110370022000_68.11.917.6","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-127-11-199712010-00006"},{"key":"2025112110370022000_68.11.917.7","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026601904609"},{"key":"2025112110370022000_68.11.917.8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2893.2003.00403.x"},{"key":"2025112110370022000_68.11.917.9","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.19347"},{"key":"2025112110370022000_68.11.917.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00218-5"},{"key":"2025112110370022000_68.11.917.11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.31.21491"},{"key":"2025112110370022000_68.11.917.12","doi-asserted-by":"publisher","DOI":"10.1042\/bj3090299"},{"key":"2025112110370022000_68.11.917.13","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2009.071621"},{"key":"2025112110370022000_68.11.917.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(01)00185-1"},{"key":"2025112110370022000_68.11.917.15","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-014-2206-8"},{"key":"2025112110370022000_68.11.917.16","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800600817"},{"key":"2025112110370022000_68.11.917.17","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.17.1.463"},{"key":"2025112110370022000_68.11.917.18","doi-asserted-by":"crossref","first-page":"G245","DOI":"10.1152\/ajpgi.2000.279.2.G245","article-title":"Fibrogenesis II. Metalloproteinases and their inhibitors in liver fibrosis","volume":"279","author":"Arthur","year":"2000","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2025112110370022000_68.11.917.19","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-17552"},{"key":"2025112110370022000_68.11.917.20","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.1997.v26.pm0009397993"},{"key":"2025112110370022000_68.11.917.21","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80151-2"},{"key":"2025112110370022000_68.11.917.22","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80264-5"},{"key":"2025112110370022000_68.11.917.23","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(00)00182-0"},{"key":"2025112110370022000_68.11.917.24","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1635"},{"key":"2025112110370022000_68.11.917.25","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1055\/s-0037-1613578","article-title":"Assessment of the clinical significance of serum matrix metalloproteinases MMP-2 and MMP-9 in patients with various chronic liver diseases and hepatocellular carcinoma","volume":"89","author":"Kuyvenhoven","year":"2003","journal-title":"Thromb Haemost"},{"key":"2025112110370022000_68.11.917.26","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/clinchem\/46.2.183","article-title":"Expression of matrix metalloproteinase-2 and -9 and their inhibitors in peripheral blood cells of patients with chronic hepatitis C","volume":"46","author":"Lichtinghagen","year":"2000","journal-title":"Clin Chem"},{"key":"2025112110370022000_68.11.917.27","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026630129025"},{"key":"2025112110370022000_68.11.917.28","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240513"},{"key":"2025112110370022000_68.11.917.29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2006.00014.x"},{"key":"2025112110370022000_68.11.917.30","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-7754(01)90137-X"},{"key":"2025112110370022000_68.11.917.31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.04908.x"},{"key":"2025112110370022000_68.11.917.32","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.09.017"},{"key":"2025112110370022000_68.11.917.33","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013215"},{"key":"2025112110370022000_68.11.917.34","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe048237"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2015-202932","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:37:11Z","timestamp":1763750231000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2015-202932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,5]]},"references-count":34,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2015,10,19]]},"published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1136\/jclinpath-2015-202932"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2015-202932","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[2015,8,5]]}}}