{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T21:02:46Z","timestamp":1771966966754,"version":"3.50.1"},"reference-count":32,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2015,3,9]]},"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Our aim was to analyse the utility of the algorithm combining PAX8 with clinicopathological characteristics (tumour size, laterality and patient age) in differentiating primary ovarian mucinous tumours (POMTs) from extragenital metastatic mucinous carcinomas involving the ovary (eMOMCs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Immunohistochemical staining for PAX8 was performed on formalin \ufb01xed, paraf\ufb01n embedded tissues from 47 POMTs, 18 eMOMCs and 70 extragenital primary mucinous carcinomas (ePMCs) using anti-PAX8 rabbit polyclonal antibody (pAb) and anti-PAX8 rabbit monoclonal antibody (mAb). PAX8 (pAb) positive signals were found in 3\/18 eMOMCs and in 32\/70 ePMCs. PAX8 (mAb) demonstrated superior specificity, with 0% positivity in both eMOMCs and ePMCs, but unfavourable sensitivity, with 60.9% in ovarian mucinous borderline tumours and 45.8% in POMCs. Although PAX8 (mAb) immunostaining status (66.2%), tumour size (75.4%) and laterality (84.6%) demonstrated unsatisfactory accuracy when they were evaluated individually in differentiating POMTs from eMOMCs, a combination of PAX8 (mAb) immunostaining status, tumour size and laterality markedly increased accuracy (86.2%), with a satisfactory Youden Index (63.7%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>PAX8 (mAb) was a specific marker in differentiating POMTs from eMOMCs. As a simple, convenient and high performance to price ratio algorithm, a combination of PAX8 (mAb) immunostaining with tumour size and laterality will improve the diagnostic criteria of ovarian mucinous metastasis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jclinpath-2015-202951","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T09:54:28Z","timestamp":1427882068000},"page":"522-528","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Differentiating primary and extragenital metastatic mucinous ovarian tumours: an algorithm combining PAX8 with tumour size and laterality"],"prefix":"10.1136","volume":"68","author":[{"given":"Ajin","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Pathology, School of Basic Medical Science, Peking University Third Hospital, Peking University Health Science Centre, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beijing Chuiyangliu Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Letian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Basic Medical Science, Peking University Third Hospital, Peking University Health Science Centre, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caixia","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Peking University Health Science Centre, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Basic Medical Science, Peking University Third Hospital, Peking University Health Science Centre, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Basic Medical Science, Peking University Third Hospital, Peking University Health Science Centre, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congrong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Basic Medical Science, Peking University Third Hospital, Peking University Health Science Centre, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,3,31]]},"reference":[{"key":"2025092504572084000_68.7.522.1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2011-200162"},{"key":"2025092504572084000_68.7.522.2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200303000-00001"},{"key":"2025092504572084000_68.7.522.3","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200307000-00014"},{"key":"2025092504572084000_68.7.522.4","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199710000-00004"},{"key":"2025092504572084000_68.7.522.5","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198909000-00004"},{"key":"2025092504572084000_68.7.522.6","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1093\/ajcp\/97.6.751","article-title":"Metastatic ovarian carcinoma of large intestinal origin simulating primary ovarian carcinoma. 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