{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T16:21:37Z","timestamp":1782750097118,"version":"3.54.5"},"reference-count":43,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2015,7,15]]},"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To analyse the differences in reticulocyte indices between delta beta thalassaemia trait (\u03b4\u03b2-TT), beta thalassaemia trait (\u03b2-TT) and iron deficiency anaemia (IDA), and to correlate those differences with the physiopathological features of these three types of microcytoses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a descriptive study of 428 samples (43 \u03b4\u03b2-TT, 179 \u03b2-TT and 206 IDA) that were run on Advia 2120 analyser (Siemens). The following reticulocyte indices were assessed: absolute reticulocyte count (ARC), percentage of reticulocytes, mean corpuscular volume of reticulocytes (MCVr), haemoglobin content of reticulocytes (CHr), mean corpuscular haemoglobin concentration of reticulocytes, red blood cell distribution width of reticulocytes (RDWr), haemoglobin distribution width of reticulocytes (HDWr) and reticulocyte subpopulations based on their fluorescence according to mRNA (low (L-R), medium (M-R) and high (H-R)), MCV ratio and MCHC ratio. Correlation between fetal haemoglobin (HbF) and RDWr in patients with thalassaemia was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>RDWr was significantly higher in \u03b4\u03b2-TT compared with \u03b2-TT (15.03% vs 13.82%, p&lt;0.001), and so were HDWr (3.65% vs 3.27%, p&lt;0.001), CHr (23.68 vs 22.66\u2005pg, p&lt;0.001) and MCVr (88.3 vs 85.5\u2005fL, p&lt;0.001). A good correlation was observed between HbF and RDWr (r=0.551, p&lt;0.001). IDA subjects have more immature reticulocytes, but less ARC than \u03b2-TT, suggesting a certain degree of inefficient erythropoiesis in IDA in comparison with \u03b2-TT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Previously described differences between \u03b4\u03b2-TT, \u03b2-TT and IDA in the corpuscular indices of mature red blood cell can also be observed in reticulocytes. The degree of anisocytosis in reticulocytes from patients with thalassaemia is correlated with HbF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2015-203034","type":"journal-article","created":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T07:36:58Z","timestamp":1453361818000},"page":"149-154","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Reticulocyte parameters of delta beta thalassaemia trait, beta thalassaemia trait and iron deficiency anaemia"],"prefix":"10.1136","volume":"69","author":[{"given":"Diego","family":"Velasco-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Department of Haematology, Laboratorio Central de la Comunidad de Madrid, Madrid, Spain"},{"name":"Programa de Doctorado de Investigaci\u00f3n en Ciencias M\u00e9dico-Quir\u00fargicas, Universidad Complutense de Madrid, Madrid, Spain"},{"name":"Department of Haematology, Hospital Ram\u00f3n y Cajal, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Manuel","family":"Alonso-Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Department of Haematology, Laboratorio Central de la Comunidad de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando-Ata\u00falfo","family":"Gonz\u00e1lez-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Haematology, Laboratorio Central de la Comunidad de Madrid, Madrid, Spain"},{"name":"Department of Haematology, Hospital Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Villarrubia","sequence":"additional","affiliation":[{"name":"Department of Haematology, Laboratorio Central de la Comunidad de Madrid, Madrid, Spain"},{"name":"Department of Haematology, Hospital Ram\u00f3n y Cajal, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Sope\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Haematology, Laboratorio Central de la Comunidad de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Abalo","sequence":"additional","affiliation":[{"name":"Department of Haematology, Laboratorio Central de la Comunidad de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Ropero","sequence":"additional","affiliation":[{"name":"Department of Haematology, Hospital Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Mart\u00ednez-Nieto","sequence":"additional","affiliation":[{"name":"Department of Haematology, Hospital Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9lix","family":"de la Fuente Gonzalo","sequence":"additional","affiliation":[{"name":"Department of Haematology, Hospital Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Cava","sequence":"additional","affiliation":[{"name":"Department of Haematology, Laboratorio Central de la Comunidad de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,8,11]]},"reference":[{"key":"2025120617560246000_69.2.149.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2010.01238.x"},{"key":"2025120617560246000_69.2.149.2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.4.1489"},{"key":"2025120617560246000_69.2.149.3","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21090"},{"key":"2025120617560246000_69.2.149.4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.23.2225"},{"key":"2025120617560246000_69.2.149.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2011.06.004"},{"key":"2025120617560246000_69.2.149.6","first-page":"631","article-title":"Erythroid bone marrow activity and red cell hemoglobinization in iron sufficient beta-thalassemia heterozygotes as reflected by soluble transferrin receptor and reticulocyte hemoglobin in content. 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