{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T09:15:22Z","timestamp":1765703722863,"version":"3.48.0"},"reference-count":30,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2015,8,28]]},"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess the value of laboratory tests available for the investigation of iron status in a population of young British South Asian children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Blood count, red cell distribution width (RDW), percentage hypochromic red cells (%hypo), concentrations of C-reactive protein (CRP), zinc protoporphyrin (ZPP), ferritin, soluble transferrin receptor, plasma iron measurements and incidence of deletional forms of \u03b1-thalassaemia were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Haemoglobin, mean cell haemoglobin (MCH), ferritin and CRP values classified iron status in 151\/205 (73.6%) consecutive children aged 4\u201343\u2005months. Fifty-four could not be classified: 12 were anaemic with findings, other than normal CRP values, indistinguishable from those with anaemia of inflammation and 42 were non-anaemic with reduced MCH values. All 42 had normal ferritin concentration and 8 of 36 successfully tested had deletional \u03b1-thalassaemia trait. Despite apparent iron sufficiency the RDW, %hypo and ZPP values of these 42 were not significantly different from the 32 children classified with iron-deficient erythropoiesis. The gene frequency of deletional \u03b1-thalassaemia trait in the entire group was 8.6%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among 205 British South Asian children aged 4\u201343\u2005months with high incidences of anaemia, iron deficiency, infection and \u03b1-thalassaemia, 151 (73.6%) were classified using haemoglobin, MCH, ferritin and CRP values. In 42 non-anaemic, iron-sufficient children with subnormal MCH values, that is with a phenotype of \u03b1-thalassaemia trait, RDW, %hypo and ZPP values did not differ significantly from those with iron-deficient erythropoiesis. Raised RDW, %hypo and ZPP values should be interpreted with caution in non-anaemic young British South Asian children with microcytosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2015-203301","type":"journal-article","created":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T23:28:09Z","timestamp":1444865289000},"page":"345-351","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["An assessment of methods used in the investigation of iron status: findings in a population of young British South Asian children"],"prefix":"10.1136","volume":"69","author":[{"given":"Roderick F","family":"Hinchliffe","sequence":"first","affiliation":[{"name":"Department of Paediatric Haematology, Sheffield Children's NHS Foundation Trust, Sheffield, UK"},{"name":"Academic Unit of Clinical Pharmacology, Department of Human Metabolism, University of Sheffield Medical School, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay J","family":"Vora","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology, Sheffield Children's NHS Foundation Trust, Sheffield, UK"},{"name":"Academic Unit of Child Health, Department of Human Metabolism, University of Sheffield Medical School, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynne","family":"Lennard","sequence":"additional","affiliation":[{"name":"Academic Unit of Clinical Pharmacology, Department of Human Metabolism, University of Sheffield Medical School, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,9,25]]},"reference":[{"key":"2025121401130593000_69.4.345.1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2002.019703"},{"key":"2025121401130593000_69.4.345.2","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.2147\/NDT.S72491","article-title":"Iron deficiency and cognitive functions","volume":"10","author":"J\u00e1uregui-Lobera","year":"2014","journal-title":"Neuropsychiatr Dis Treat"},{"key":"2025121401130593000_69.4.345.3","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.160.11.1108"},{"key":"2025121401130593000_69.4.345.4","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-303160"},{"key":"2025121401130593000_69.4.345.5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.8.924"},{"key":"2025121401130593000_69.4.345.6","unstructured":"Fairbanks VF , Beutler E . 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