{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:17:01Z","timestamp":1787163421240,"version":"build-2736575974"},"reference-count":29,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2015,10,3]]},"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Light chain deposition disease (LCDD) is usually a systemic disorder characterised by non-amyloid monoclonal immunoglobulin light chain deposition in tissues. Localised nodular pulmonary (NP) LCDD is a rare and poorly characterised entity and, owing to the difficulties in diagnosis, limited data are available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We investigated the clinical, radiological and pathological characteristics of a series of six confidently diagnosed cases of NPLCDD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were three men and three women with ages ranging from 33 to 74\u2005years. In all cases there were single or multiple pulmonary nodules, in one case associated with cysts. Two patients had no previous history of a lymphoproliferative or autoimmune disorder, two had Sj\u00f6gren syndrome (SS) and two had extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). Lung biopsies led to diagnoses of MALT lymphoma in four patients, including both of those with a previous history of lymphoma and one with SS. In five cases the diagnosis was confirmed by liquid chromatography\u2013tandem mass spectrometry (LC\u2013MS\/MS) and in one by electron microscopy. There was no evidence of systemic LCDD in any of the cases. Five patients had an indolent course in spite of limited therapeutic intervention while, in the patient who died, the cause of death was related to the spread of the lymphoma and was not due to the pulmonary lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NPLCDD is an indolent disease, in most cases associated with MALT lymphoma or autoimmune disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2015-203342","type":"journal-article","created":{"date-parts":[[2016,5,19]],"date-time":"2016-05-19T19:41:20Z","timestamp":1463686880000},"page":"490-496","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":37,"title":["Nodular pulmonary light chain deposition disease: an entity associated with Sj\u00f6gren syndrome or marginal zone lymphoma"],"prefix":"10.1136","volume":"69","author":[{"given":"A V","family":"Arrossi","sequence":"first","affiliation":[{"name":"R.J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Merzianu","sequence":"additional","affiliation":[{"name":"Departement of Pathology, Roswell Park Cancer Institute, Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Farver","sequence":"additional","affiliation":[{"name":"R.J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Yuan","sequence":"additional","affiliation":[{"name":"R.J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S H","family":"Wang","sequence":"additional","affiliation":[{"name":"R.J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M O","family":"Nakashima","sequence":"additional","affiliation":[{"name":"R.J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C V","family":"Cotta","sequence":"additional","affiliation":[{"name":"R.J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,10,26]]},"reference":[{"key":"2025092506045532000_69.6.490.1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213358.18380.d2"},{"key":"2025092506045532000_69.6.490.2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201301-0071LE"},{"key":"2025092506045532000_69.6.490.3","unstructured":"Swerdlow S , Campo E , Harris NL , et al . WHO classification of tumours of haematopoietic and lymphoid tissues. 4th edn. Lyon, France: IARC, 2008."},{"key":"2025092506045532000_69.6.490.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65520-4"},{"key":"2025092506045532000_69.6.490.5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-123596"},{"key":"2025092506045532000_69.6.490.6","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e3181e4dd44"},{"key":"2025092506045532000_69.6.490.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2009.01560.x"},{"key":"2025092506045532000_69.6.490.8","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200510-1620CR"},{"key":"2025092506045532000_69.6.490.9","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201404-137OC"},{"key":"2025092506045532000_69.6.490.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2015.01.002"},{"key":"2025092506045532000_69.6.490.11","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00134406"},{"key":"2025092506045532000_69.6.490.12","doi-asserted-by":"publisher","DOI":"10.1097\/00005382-199707000-00009"},{"key":"2025092506045532000_69.6.490.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2013.01.005"},{"key":"2025092506045532000_69.6.490.14","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPI08WAKYVLHHA"},{"key":"2025092506045532000_69.6.490.15","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318272fe19"},{"issue":"(Suppl. 2)","key":"2025092506045532000_69.6.490.16","first-page":"491A","article-title":"Clonality studies in nodular amyloid deposition","volume":"27","author":"Racila","year":"2014","journal-title":"Mod Pathol"},{"key":"2025092506045532000_69.6.490.17","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/100.2.135"},{"key":"2025092506045532000_69.6.490.18","first-page":"557","article-title":"Kappa light chain glomerulosclerosis in multiple myeloma","volume":"101","author":"Seymour","year":"1980","journal-title":"Am J Pathol"},{"key":"2025092506045532000_69.6.490.19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198101013040108"},{"key":"2025092506045532000_69.6.490.20","first-page":"93","article-title":"Association of systemic light-chain deposition disease and amyloidosis: a report of three patients with renal involvement","volume":"24","author":"Jacquot","year":"1985","journal-title":"Clin Nephrol"},{"key":"2025092506045532000_69.6.490.21","first-page":"17","article-title":"Renal and systemic kappa light chain deposits and their plasma cell origin identified by immunoelectron microscopy","volume":"122","author":"Silver","year":"1986","journal-title":"Am J Pathol"},{"key":"2025092506045532000_69.6.490.22","doi-asserted-by":"publisher","DOI":"10.1159\/000185616"},{"key":"2025092506045532000_69.6.490.23","first-page":"749","article-title":"Light chain deposition disease derived from the kappa I light chain subgroup. biochemical characterization","volume":"134","author":"Picken","year":"1989","journal-title":"Am J Pathol"},{"key":"2025092506045532000_69.6.490.24","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198712000-00010"},{"key":"2025092506045532000_69.6.490.25","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198805000-00009"},{"key":"2025092506045532000_69.6.490.26","first-page":"1059","article-title":"Nodular pulmonary immunoglobulin light chain deposits with coexistent amyloid and nonamyloid features in an HIV-infected patient","volume":"10","author":"Stokes","year":"1997","journal-title":"Mod Pathol"},{"key":"2025092506045532000_69.6.490.27","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1998.00393.x"},{"key":"2025092506045532000_69.6.490.28","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03781.x"},{"key":"2025092506045532000_69.6.490.29","doi-asserted-by":"publisher","DOI":"10.1309\/3GECPW2402F6V8EK"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2015-203342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T13:05:07Z","timestamp":1758805507000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2015-203342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,26]]},"references-count":29,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,5,19]]},"published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1136\/jclinpath-2015-203342"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2015-203342","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,26]]}}}