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Although B cells have been the main focus of the disorder, ample experimental data suggest that T-cell abnormalities can be seen in a large proportion of Freiburg Group 1a patients and those suffering from inflammatory complications. The reductions in T-cell receptor excision circles, na\u00efve T cells, invariant NKT cells and regulatory T cells suggest a diminished thymic output, while CD8 T cells are driven towards exhaustion either via an antigen-dependent or an antigen-independent manner. The theoretical risk of anti-T-cell therapies is discussed, highlighting the need for an international effort in generating longitudinal data in addition to better-defined underlying molecular characterisation.<\/jats:p>","DOI":"10.1136\/jclinpath-2015-203351","type":"journal-article","created":{"date-parts":[[2016,5,7]],"date-time":"2016-05-07T09:31:44Z","timestamp":1462613504000},"page":"672-676","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":48,"title":["T-cell abnormalities in common variable immunodeficiency: the hidden defect"],"prefix":"10.1136","volume":"69","author":[{"given":"Gabriel K","family":"Wong","sequence":"first","affiliation":[{"name":"MRC Centre for Immune Regulation, University of Birmingham, Birmingham, UK"},{"name":"West Midlands Primary Immunodeficiency Centre, Birmingham Heartlands Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarnoud 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