{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:10:00Z","timestamp":1763748600275,"version":"3.45.0"},"reference-count":14,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2016,2,23]]},"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transforming growth factor \u03b1 (TGF\u03b1) is a peptide growth factor known to be expressed in normal haemopoiesis. It is also expressed in a range of epithelial neoplasms but has not been assessed in haemopoietic malignancies. We have performed an immunohistochemical evaluation of TGF\u03b1 in acute and chronic myeloid malignancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>TGF\u03b1 expression was semiquantitatively assessed in 69 normal bone marrow trephines and 157 cases of myeloid malignancy using an immunohistochemical approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Blast cells of myeloid origin in acute myeloid leukaemia (AML), myelodysplasia and accelerated and blast phases of chronic myeloid leukaemia (CML) were TGF\u03b1 positive. In acute promyelocytic leukaemia the neoplastic cells had significantly weaker TGF\u03b1 expression than seen in other forms of AML. The blast cells in CML-accelerated and blast phases were positive with similar expression to AML.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TGF\u03b1 is expressed in neoplastic myeloblasts and could, therefore, be used as blast cell biomarker in diagnostic haematopathology. In addition, TGF\u03b1 immunohistochemistry may be of use in identifying a therapeutic target.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2015-203526","type":"journal-article","created":{"date-parts":[[2016,3,16]],"date-time":"2016-03-16T23:18:43Z","timestamp":1458170323000},"page":"543-546","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["TGF\u03b1 expression in myeloid malignancies"],"prefix":"10.1136","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5809-2882","authenticated-orcid":false,"given":"Simon","family":"Kavanagh","sequence":"first","affiliation":[{"name":"Pathology and Laboratory Medicine, The University of Western Australia, Crawley, Western Australia, Australia"},{"name":"PathWest Laboratory Medicine, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bob","family":"Mirzai","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, The University of Western Australia, Crawley, Western Australia, Australia"},{"name":"PathWest Laboratory Medicine, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Fuller","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, The University of Western Australia, Crawley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy N","family":"Erber","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, The University of Western Australia, Crawley, Western Australia, Australia"},{"name":"PathWest Laboratory Medicine, Nedlands, Western Australia, 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