{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:48:41Z","timestamp":1765007321579,"version":"3.46.0"},"reference-count":37,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2016,4,24]]},"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Despite almost pathognomonic status of ectopic crypt foci (ECF) in the diagnosis of traditional serrated adenoma (TSA), there are few systematic studies on their prevalence in other types of colon polyps or in adenomas adjacent to colorectal cancer (CRC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We calculated ECF in all the polyps (n=922) removed in the colonoscopy in Oulu University Hospital in 2001. Moreover, to study ECF in precursor lesions next to CRCs, we re-examined a previously described cohort of 148 CRCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ECF were seen in 53 (5.7%) polyps representing 28 (6.5%) tubular adenomas (TAs), 14 (53.8%) tubulovillous adenomas (TVAs), 2 (100.0%) villous adenomas (VAs) and 9 (100.0%) TSAs. In all TSAs and VAs, the density of ECF was higher than in TVAs and TAs. An adjacent precursor lesion was recognised in 28 of 148 (18.9%) CRCs. Twenty-four (85.7%) of these contained ECF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ECF can most frequently be observed in TSAs but also in many TVAs, VAs and TAs, reflecting a histological overlap between serrated and conventional polyps. Especially, precursor lesions adjacent to CRC frequently contain ECF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2015-203593","type":"journal-article","created":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T13:41:51Z","timestamp":1465479711000},"page":"1063-1069","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Ectopic crypt foci in conventional and serrated colorectal polyps"],"prefix":"10.1136","volume":"69","author":[{"given":"Sara A","family":"V\u00e4yrynen","sequence":"first","affiliation":[{"name":"Cancer and Translational Medicine Research Unit, University of Oulu, Oulu, Finland"},{"name":"Oulu University Hospital and Medical Research Center Oulu, Oulu, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha P","family":"V\u00e4yrynen","sequence":"additional","affiliation":[{"name":"Cancer and Translational Medicine Research Unit, University of Oulu, Oulu, Finland"},{"name":"Oulu University Hospital and Medical Research Center Oulu, Oulu, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Klintrup","sequence":"additional","affiliation":[{"name":"Oulu University Hospital and Medical Research Center Oulu, Oulu, Finland"},{"name":"Research Unit of Surgery, Anesthesia and Intensive Care, University of Oulu, Oulu, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyrki","family":"M\u00e4kel\u00e4","sequence":"additional","affiliation":[{"name":"Oulu University Hospital and Medical Research Center Oulu, Oulu, Finland"},{"name":"Research Unit of Surgery, Anesthesia and Intensive Care, University of Oulu, Oulu, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Tuomisto","sequence":"additional","affiliation":[{"name":"Cancer and Translational Medicine Research Unit, University of Oulu, Oulu, Finland"},{"name":"Oulu University Hospital and Medical Research Center Oulu, Oulu, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus J","family":"M\u00e4kinen","sequence":"additional","affiliation":[{"name":"Cancer and Translational Medicine Research Unit, University of Oulu, Oulu, Finland"},{"name":"Oulu University Hospital and Medical Research Center Oulu, Oulu, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,6,8]]},"reference":[{"key":"2025120523434103000_69.12.1063.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2006.02548.x"},{"key":"2025120523434103000_69.12.1063.2","doi-asserted-by":"publisher","DOI":"10.1111\/his.12055"},{"key":"2025120523434103000_69.12.1063.3","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90186-I"},{"key":"2025120523434103000_69.12.1063.4","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.2820360944"},{"key":"2025120523434103000_69.12.1063.5","unstructured":"Snover D , Ahnen D , Burt R , et al . Serrated polyps of the colon and rectum and serrated (\u2018hyperplastic\u2019) polyposis. In: WHO classification of tumours. Pathology and genetics. Tumours of the digestive system. 4th edn. Berlin: Springer-Verlag, 2010:160\u20135."},{"key":"2025120523434103000_69.12.1063.6","doi-asserted-by":"publisher","DOI":"10.2217\/crc.13.84"},{"key":"2025120523434103000_69.12.1063.7","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2008.061960"},{"key":"2025120523434103000_69.12.1063.8","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000103"},{"key":"2025120523434103000_69.12.1063.9","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197912000-00001"},{"key":"2025120523434103000_69.12.1063.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02180.x"},{"key":"2025120523434103000_69.12.1063.11","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.06.001"},{"key":"2025120523434103000_69.12.1063.12","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-014-1569-7"},{"key":"2025120523434103000_69.12.1063.13","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.315"},{"key":"2025120523434103000_69.12.1063.14","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2011.645499"},{"key":"2025120523434103000_69.12.1063.15","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2011.5"},{"key":"2025120523434103000_69.12.1063.16","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318157f002"},{"key":"2025120523434103000_69.12.1063.17","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1097\/PAS.0000000000000253","article-title":"Morphologic and molecular characterization of traditional serrated adenomas of the distal colon and rectum","volume":"38","author":"Wiland","year":"2014","journal-title":"Am J Surg Pathol"},{"key":"2025120523434103000_69.12.1063.18","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPVT7LC4CRPZSK"},{"key":"2025120523434103000_69.12.1063.19","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.161"},{"key":"2025120523434103000_69.12.1063.20","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-012-1319-7"},{"key":"2025120523434103000_69.12.1063.21","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPDJC9VC5KTYUS"},{"key":"2025120523434103000_69.12.1063.22","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/modpathol.2014.122","article-title":"A clinicopathological and molecular analysis of 200 traditional serrated adenomas","volume":"28","author":"Bettington","year":"2014","journal-title":"Mod Pathol"},{"key":"2025120523434103000_69.12.1063.23","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.456"},{"key":"2025120523434103000_69.12.1063.24","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.456"},{"key":"2025120523434103000_69.12.1063.25","unstructured":"Hamilton SR , Bosman FT , Boffetta P , et al . Carcinoma of the colon and rectum. In: Bosman F , Carneiro F , Hruban R , et al ., eds. WHO classification of tumours of the digestive system. Lyon: IARC Press, 2010:134\u201346."},{"key":"2025120523434103000_69.12.1063.26","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-014-1555-0"},{"key":"2025120523434103000_69.12.1063.27","doi-asserted-by":"publisher","DOI":"10.1126\/science.1093587"},{"key":"2025120523434103000_69.12.1063.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2010.06.002"},{"key":"2025120523434103000_69.12.1063.29","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-014-1683-6"},{"key":"2025120523434103000_69.12.1063.30","doi-asserted-by":"publisher","DOI":"10.1002\/path.4200"},{"key":"2025120523434103000_69.12.1063.31","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12284"},{"key":"2025120523434103000_69.12.1063.32","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181c6b9dd"},{"key":"2025120523434103000_69.12.1063.33","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.52.1.5"},{"key":"2025120523434103000_69.12.1063.34","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-005-1226-2"},{"key":"2025120523434103000_69.12.1063.35","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1097\/PAS.0b013e3181d40cb2","article-title":"KRAS mutations in traditional serrated adenomas from Korea herald an aggressive phenotype","volume":"34","author":"Kim","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"2025120523434103000_69.12.1063.36","doi-asserted-by":"publisher","DOI":"10.1111\/his.12555"},{"key":"2025120523434103000_69.12.1063.37","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-014-0212-x"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2015-203593","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:43:51Z","timestamp":1765007031000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2015-203593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,8]]},"references-count":37,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2016,11,18]]},"published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1136\/jclinpath-2015-203593"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2015-203593","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[2016,6,8]]}}}