{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:31:06Z","timestamp":1764995466519,"version":"3.46.0"},"reference-count":11,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2016,10,26]]},"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To examine the need for minimal diagnostic criteria for post-transplant lymphoproliferative disorders (PTLD) in children, we sought to determine the rate of incidental Epstein-Barr virus (EBV)-positivity in tissues from organ transplant recipients (OTR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>EBV in situ hybridisation (ISH) was done retrospectively on tissue from 34 paediatric autopsies of OTR and paediatric tonsillectomy specimens from non-OTR (96) and OTR (6). Patients with a history of PTLD were excluded from both data sets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>EBV-positivity was found incidentally in 2\/34 autopsy cases (5.9%). Median time from transplant to death for all patients was 12.8\u2005months (range 0.1\u2013153\u2005months). Median time between transplant and death in EBV-positive cases was 34\u2005months. EBV was positive in 26\/102 tonsils (25%). Among tonsils from OTR, 4\/6 (67%) were EBV-positive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings reinforce the need for strict morphological and clinical criteria, other than EBV-positivity, when diagnosing PTLD in the paediatric population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2016-203924","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T20:27:53Z","timestamp":1479328073000},"page":"270-273","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Incidental EBV-positivity in paediatric post-transplant specimens demonstrates the need for stringent criteria for diagnosing post-transplant lymphoproliferative disorders"],"prefix":"10.1136","volume":"70","author":[{"given":"Rebecca L","family":"King","sequence":"first","affiliation":[{"name":"Division of Hematopathology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele E","family":"Paessler","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew T","family":"Howard","sequence":"additional","affiliation":[{"name":"Division of Hematopathology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald B","family":"Wertheim","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,11,15]]},"reference":[{"key":"2025120519525372000_70.3.270.1","unstructured":"Swerdlow S , Campo E , Harris N , et al ., eds. 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