{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:13:18Z","timestamp":1768522398278,"version":"3.49.0"},"reference-count":42,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2016,11,9]]},"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      To evaluate the contribution of light microscopy to detecting\n                      <jats:italic>Candida<\/jats:italic>\n                      spp infection in patients with complicated intra-abdominal infections (IAIs) admitted for acute abdomen to a quality assurance (QA)-certified surgical emergency ward.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective study (2008\u20132012) of 809 abdominal intraoperative or biopsy tissue specimens obtained from patients admitted with acute abdomen and microbiological samples positive for\n                      <jats:italic>Candida<\/jats:italic>\n                      spp. Demographic data, mortality, comorbidities, specimen type, microscopy results, special histological staining performed, antimicrobial therapy were collected and analysed. Any comments at the multidisciplinary team meeting was recorded in minutes of and approved.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty-six patients with complicated IAIs due to\n                      <jats:italic>Candida<\/jats:italic>\n                      spp were identified (39 male, 27 female, mean\u00b1SD age 75\u00b120\u2005years).\n                      <jats:italic>Candida albicans<\/jats:italic>\n                      was isolated in 35 cases and\n                      <jats:italic>Candida non-albicans<\/jats:italic>\n                      spp in 31 cases.\n                      <jats:italic>Candida<\/jats:italic>\n                      spp were isolated from blood in 50% of all selected microbiological specimens. Patients were stratified according to\n                      <jats:italic>Candida<\/jats:italic>\n                      spp\n                      <jats:italic>(albicans<\/jats:italic>\n                      vs\n                      <jats:italic>non-albicans)<\/jats:italic>\n                      , underlying cancer disease and no previous antimicrobial administration, and a positive correlation with\n                      <jats:italic>C. albicans<\/jats:italic>\n                      isolation was found (p=0.009 and p=0.048, respectively). Out of 41 cases with microscopic evaluation, we identified yeast forms, pseudohyphae or both, indicative of\n                      <jats:italic>Candida<\/jats:italic>\n                      spp, in 23. Identification of\n                      <jats:italic>Candida<\/jats:italic>\n                      spp in histological specimens was higher in\n                      <jats:italic>C. albicans<\/jats:italic>\n                      cases than in\n                      <jats:italic>C. non-albicans<\/jats:italic>\n                      cases (73% vs 37.5%). Microscopy allowed prompt treatment of all patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Light microscopy still has great diagnostic significance, being a solid QA step. It provides rapid information and clues in patients who may harbour impaired defence mechanisms, concurrent chronic conditions and\/or cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2016-203936","type":"journal-article","created":{"date-parts":[[2016,12,10]],"date-time":"2016-12-10T04:03:02Z","timestamp":1481342582000},"page":"579-583","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Intra-abdominal\n                    <i>Candida<\/i>\n                    spp infection in acute abdomen in a quality assurance (QA)-certified academic setting"],"prefix":"10.1136","volume":"70","author":[{"given":"Vito","family":"Rodolico","sequence":"first","affiliation":[{"name":"Department of Sciences for Health Promotion and Mother & Child Care, Section of Anatomic Pathology, University of Palermo, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Di Carlo","sequence":"additional","affiliation":[{"name":"Department of Sciences for Health Promotion and Mother & Child Care, Section of Infectious Disease, University of Palermo, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaspare","family":"Gulotta","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Emergency, University of Palermo, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"D'Arpa","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Emergency, University of Palermo, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Salamone","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Emergency, University of Palermo, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Cocorullo","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Emergency, University of Palermo, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Agrusa","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Emergency, University of Palermo, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Giammanco","sequence":"additional","affiliation":[{"name":"Department of Sciences for Health Promotion and Mother & Child Care, Section of Microbiology, University of Palermo, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Consolato","family":"Sergi","sequence":"additional","affiliation":[{"name":"Department of Lab. 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