{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:00:30Z","timestamp":1773680430668,"version":"3.50.1"},"reference-count":50,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2016,7,10]]},"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Mesothelial reaction simulating peritoneal diffuse malignant mesothelioma (MM) has been reported in the setting of Crohn ileitis. To our knowledge, peritoneal MM arising in patients with inflammatory bowel disease (IBD) has not been reported. The purpose of this study is to report the clinicopathological characteristics of patients with peritoneal MM and IBD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A database of approximately 3800 MM was reviewed for cases of MM in patients with IBD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Three patients (0.08%) with peritoneal MM and Crohn disease (CD) were identified, including two women and one man ranging in age from 56 to 65\u2005years. All had a long-standing history of diarrhoea and an established diagnosis of CD of 3\u2005years or greater duration. Two had epithelial MM and one had biphasic MM. Only one had documented asbestos exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Peritoneal MM occurs rarely in patients with IBD, but interestingly, has only been observed in the setting of CD and not in patients with ulcerative colitis. Chronic inflammation has been associated with the development of MM in rare instances and these three cases suggest that CD with transmural inflammation may also be a precursor. The precise role of CD-related transmural inflammation in the carcinogenesis of peritoneal MM remains to be determined.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2016-203945","type":"journal-article","created":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T22:39:08Z","timestamp":1470177548000},"page":"228-232","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Malignant peritoneal mesothelioma and Crohn disease"],"prefix":"10.1136","volume":"70","author":[{"given":"Kelly J","family":"Butnor","sequence":"first","affiliation":[{"name":"Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA"},{"name":"Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, Vermont, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth N","family":"Pavlisko","sequence":"additional","affiliation":[{"name":"Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A","family":"Sporn","sequence":"additional","affiliation":[{"name":"Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor L","family":"Roggli","sequence":"additional","affiliation":[{"name":"Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,8,2]]},"reference":[{"key":"2025121219403646000_70.3.228.1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.51.12.804"},{"key":"2025121219403646000_70.3.228.2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199706000-00023"},{"key":"2025121219403646000_70.3.228.3","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820601)49:11<2431::AID-CNCR2820491134>3.0.CO;2-W"},{"key":"2025121219403646000_70.3.228.4","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850501)55:9<1968::AID-CNCR2820550923>3.0.CO;2-9"},{"key":"2025121219403646000_70.3.228.5","first-page":"250","article-title":"Malignant mesothelioma associated with chronic empyema with elevation of serum CYFRA19: a case report","volume":"2","author":"Kodama","year":"2008","journal-title":"Biosci Trends"},{"key":"2025121219403646000_70.3.228.6","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821201)50:11<2423::AID-CNCR2820501130>3.0.CO;2-I"},{"key":"2025121219403646000_70.3.228.7","first-page":"687","article-title":"[Occurrence of pleural mesothelioma. 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