{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:41:31Z","timestamp":1789940491350,"version":"4.0.1"},"reference-count":34,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2016,10,8]]},"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      To characterise clinicopathological features and clinical outcomes of the genitourinary tract solitary fibrous tumours, incorporating\n                      <jats:italic>NAB2<\/jats:italic>\n                      -\n                      <jats:italic>STAT6<\/jats:italic>\n                      gene fusion status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The presence of the molecular hallmark\n                      <jats:italic>NAB2<\/jats:italic>\n                      -\n                      <jats:italic>STAT6<\/jats:italic>\n                      gene fusion and for the defining fusion partner product STAT6 was assessed in 11 cases of the genitourinary tract solitary fibrous tumours.\n                      <jats:italic>NAB2<\/jats:italic>\n                      -\n                      <jats:italic>STAT6<\/jats:italic>\n                      gene fusion analysis was performed using a break-apart fluorescence in situ hybridisation (FISH) probe using a probe cocktail with Bacterial artificial chromosome (BAC) clones for\n                      <jats:italic>STAT6<\/jats:italic>\n                      and\n                      <jats:italic>NAB2<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eleven solitary fibrous tumours were diagnosed in eight male patients and three female patients with a mean age of 46\u2005years (range: 11\u201364\u2005years). Four of the tumours had malignant histological features, and three were considered moderate risk for metastasis. With a mean follow-up time of 61\u2005months, 1 recurred locally and 2 presented at distant metastatic sites. Using a break-apart FISH probe cocktail, we found the\n                      <jats:italic>NAB2<\/jats:italic>\n                      -\n                      <jats:italic>STAT6<\/jats:italic>\n                      gene fusion and nuclear STAT6 expression in 58% and 91% of cases, respectively. However, the\n                      <jats:italic>NAB2<\/jats:italic>\n                      -\n                      <jats:italic>STAT6<\/jats:italic>\n                      fusion status was not correlated with STAT6 expression or useful in discriminating between malignant histological features or subsequent clinical outcomes in the genitourinary solitary fibrous tumours.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      A subset of solitary fibrous tumours of the genitourinary tract behaved aggressively. Using a break-apart FISH probe cocktail, we found the\n                      <jats:italic>NAB2<\/jats:italic>\n                      -\n                      <jats:italic>STAT6<\/jats:italic>\n                      gene fusion in 64% of cases. However, the\n                      <jats:italic>NAB2<\/jats:italic>\n                      -\n                      <jats:italic>STAT6<\/jats:italic>\n                      fusion status was not correlated with STAT6 expression or useful in discriminating between low-risk or high-risk tumours and subsequent clinical outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2016-204088","type":"journal-article","created":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T21:31:18Z","timestamp":1477949478000},"page":"508-514","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Solitary fibrous tumour of the genitourinary tract: a clinicopathological study of 11 cases and their association with the\n                    <i>NAB2<\/i>\n                    -\n                    <i>STAT6<\/i>\n                    fusion gene"],"prefix":"10.1136","volume":"70","author":[{"given":"Erik","family":"Kouba","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Novae B","family":"Simper","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoxiong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean R","family":"Williamson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Henry Ford Health System, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Grignon","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N","family":"Eble","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory T","family":"MacLennan","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine, Case Western Reserve University, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Montironi","sequence":"additional","affiliation":[{"name":"Department of Pathological Anatomy and Histopathology, School of Medicine, Polytechnic University of the Marche Region (Ancona), Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Lopez-Beltran","sequence":"additional","affiliation":[{"name":"Unit of Anatomical Pathology, Department of Surgery, Faculty of Medicine, Cordoba, Spain"},{"name":"Champalimaud Clinical Center, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeboye O","family":"Osunkoya","sequence":"additional","affiliation":[{"name":"Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaobo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingsheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Wang","sequence":"additional","affiliation":[{"name":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thu","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E","family":"Emerson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee Ann","family":"Baldrige","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Francesca","family":"Monn","sequence":"additional","affiliation":[{"name":"Department of Urology, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Linos","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA"},{"name":"Department of Urology, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,10,31]]},"reference":[{"key":"2025112110343585000_70.6.508.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.02.019"},{"key":"2025112110343585000_70.6.508.2","doi-asserted-by":"publisher","DOI":"10.1177\/1066896915627485"},{"key":"2025112110343585000_70.6.508.3","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-014-0224-6"},{"key":"2025112110343585000_70.6.508.4","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10328"},{"key":"2025112110343585000_70.6.508.5","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2509"},{"key":"2025112110343585000_70.6.508.6","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2522"},{"key":"2025112110343585000_70.6.508.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2014.11.018"},{"key":"2025112110343585000_70.6.508.8","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2015.90"},{"key":"2025112110343585000_70.6.508.9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064497"},{"key":"2025112110343585000_70.6.508.10","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.83"},{"key":"2025112110343585000_70.6.508.11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140362"},{"key":"2025112110343585000_70.6.508.12","doi-asserted-by":"publisher","DOI":"10.1111\/his.12772"},{"key":"2025112110343585000_70.6.508.13","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPN25NJTOUNPNF"},{"key":"2025112110343585000_70.6.508.14","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3243-8"},{"key":"2025112110343585000_70.6.508.15","unstructured":"Fletcher CDM , Bridge JA , Hogendoorn P , et al . WHO classification of tumors of soft tissue and bone. LARC Press 2013."},{"key":"2025112110343585000_70.6.508.16","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2014.18"},{"key":"2025112110343585000_70.6.508.17","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22162"},{"key":"2025112110343585000_70.6.508.18","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.56"},{"key":"2025112110343585000_70.6.508.19","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318209edb9"},{"key":"2025112110343585000_70.6.508.20","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.6993"},{"key":"2025112110343585000_70.6.508.21","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-0851"},{"key":"2025112110343585000_70.6.508.22","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12408"},{"key":"2025112110343585000_70.6.508.23","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213416.23256.71"},{"key":"2025112110343585000_70.6.508.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2016.03.011"},{"key":"2025112110343585000_70.6.508.25","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.3892\/ol.2015.3379","article-title":"Solitary fibrous tumors of the prostate: a case report","volume":"10","author":"Yang","year":"2015","journal-title":"Oncol Lett"},{"key":"2025112110343585000_70.6.508.26","first-page":"2737","article-title":"Solitary fibrous tumor of the kidney with focus on clinical and pathobiological aspects","volume":"7","author":"Kuroda","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"2025112110343585000_70.6.508.27","doi-asserted-by":"publisher","DOI":"10.1159\/000354394"},{"key":"2025112110343585000_70.6.508.28","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-6-96"},{"key":"2025112110343585000_70.6.508.29","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22083"},{"key":"2025112110343585000_70.6.508.30","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2015.70"},{"key":"2025112110343585000_70.6.508.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.12.016"},{"key":"2025112110343585000_70.6.508.32","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13256-014-0505-4","article-title":"Massive malignant solitary fibrous tumor arising from the bladder serosa: a case report","volume":"9","author":"Dozier","year":"2015","journal-title":"J Med Case Rep"},{"key":"2025112110343585000_70.6.508.33","doi-asserted-by":"publisher","DOI":"10.1177\/1066896913481061"},{"key":"2025112110343585000_70.6.508.34","first-page":"1170","article-title":"Solitary fibrous tumor of the adrenal gland","volume":"9","author":"Pr\u00e9vot","year":"1996","journal-title":"Mod Pathol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2016-204088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:34:44Z","timestamp":1763750084000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2016-204088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,31]]},"references-count":34,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,5,22]]},"published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1136\/jclinpath-2016-204088"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2016-204088","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,31]]}}}