{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:47:38Z","timestamp":1775065658857,"version":"3.50.1"},"reference-count":8,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2017,3,30]]},"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Automated solid-phase antibody screening uses red blood cell (RBC) membranes immobilised on polystyrene test wells to detect RBC specific antibodies. Despite its time-saving and labour-saving benefits, this method produces a higher rate of nonspecific reactivity compared with manual screening. Solid-phase panreactivity (SPP) is characterised by panreactivity (ie, all test cells reacting) in solid-phase testing accompanied by a negative autocontrol and a lack of reactivity when the same screening cells are tested in tube. The mechanisms underlying SPP and its clinical significance remain unclear. The goals of this study were to describe the prevalence of SPP at our institution and determine the alloimmunisation and transfusion reaction rates within this population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data were collected on all patients undergoing type and screen testing over a 6-year period. Study patients undergoing subsequent transfusion were evaluated for reported transfusion reactions and development of new alloantibodies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 76\u2005051 patients studied, 0.7% demonstrated SPP of which 11% developed new alloantibodies. The transfusion reaction reporting rate among patients with SPP was 2%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our data suggest that patients with SPP have higher rates of reported transfusion reactions and alloantibody development compared with those without SPP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jclinpath-2017-204355","type":"journal-article","created":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T20:45:23Z","timestamp":1492634723000},"page":"981-983","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Increased alloimmunisation and transfusion reaction reporting in patients with solid-phase panreactivity"],"prefix":"10.1136","volume":"70","author":[{"given":"Andrea M","family":"Olofson","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael M","family":"Chandler","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia R","family":"Marx-Wood","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig A","family":"Babcock","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy M","family":"Dunbar","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA"},{"name":"Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,4,19]]},"reference":[{"key":"2025092504040655000_70.11.981.1","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1111\/j.1537-2995.2008.01736.x","article-title":"Antibody identification using both automated solid-phase red cell adherence assay and a tube polyethylene glycol antiglobulin method","volume":"48","author":"Yamada","year":"2008","journal-title":"Transfusion"},{"key":"2025092504040655000_70.11.981.2","doi-asserted-by":"crossref","unstructured":"O'Brien K , Mohammed M , Driscoli A , et al . Capture-R only \u201cpanagglutinins\u201d: examination of clinical significance [Abstract]. Transfusion 2015;55:134A. doi:10.1111\/trf.12814","DOI":"10.1111\/trf.12814"},{"key":"2025092504040655000_70.11.981.3","unstructured":"Meade T , Armstrong SM , Sanford K . The development of alloantibodies in patients that demonstrate Capture-R solid phase phenomenon [Abstract]. Transfusion 2012;52:143A."},{"key":"2025092504040655000_70.11.981.4","doi-asserted-by":"crossref","unstructured":"Klein HG , Anstee DJ . Haemolytic transfusion reactions. In: Klein HG, Anstee DJ, eds. Mollison's blood transfusion in clinical medicine. West Sussex: Wiley Blackwell, 2014:458\u201398.","DOI":"10.1002\/9781118689943.ch11"},{"key":"2025092504040655000_70.11.981.5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1046\/j.1537-2995.1985.25185116495.x","article-title":"A solid-phase antiglobulin test","volume":"25","author":"Rachel","year":"1985","journal-title":"Transfusion"},{"key":"2025092504040655000_70.11.981.6","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/82.6.719"},{"key":"2025092504040655000_70.11.981.7","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0887-7963(91)70193-4","article-title":"The principles and applications of solid-phase blood group serology","volume":"5","author":"Scott","year":"1991","journal-title":"Transfus Med Rev"},{"key":"2025092504040655000_70.11.981.8","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.3109\/14767058.2015.1107540","article-title":"Non-specific red cell reactivity in an obstetric population","volume":"29","author":"Van Winden","year":"2016","journal-title":"J Matern Fetal Neonatal Med"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2017-204355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T11:04:15Z","timestamp":1758798255000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2017-204355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,19]]},"references-count":8,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,10,25]]},"published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1136\/jclinpath-2017-204355"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2017-204355","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,19]]}}}