{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:06:07Z","timestamp":1760043967387,"version":"3.44.0"},"reference-count":18,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2017,3,16]]},"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>\n                  <jats:italic>Tropheryma whipplei<\/jats:italic>, the agent of Whipple disease, causes a rare bacterial disease that may be fatal if not treated. The classical form of the disease includes diarrhoea, weight loss, arthritis, endocarditis and neurological manifestations. Genotyping studies done in Europe, Africa and Asia showed high genetic diversity with no correlation between genotypes and clinical features, but contributed to a better understanding of the epidemiology of the disease. More than 70 genotypes have been described. No similar assessment of <jats:italic>T. whipplei<\/jats:italic> in the USA and the Caribbean has been performed. In this study, we describe genetic analysis of DNA from histopathological samples obtained from 30 patients from the Americas with Whipple disease and compare the genotypes with those previously identified. Complete genotypes were obtained from 18 patients (60%). Only 4 genotypes were previously described, and 14 were newly reported, confirming the diversity of <jats:italic>T. whipplei<\/jats:italic> strains.<\/jats:p>","DOI":"10.1136\/jclinpath-2017-204382","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T22:34:28Z","timestamp":1491518068000},"page":"891-895","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Genotypic analysis of <i>Tropheryma whipplei<\/i> from patients with Whipple disease in the Americas"],"prefix":"10.1136","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8454-685X","authenticated-orcid":false,"given":"Dominique C","family":"Rollin","sequence":"first","affiliation":[{"name":"Infectious Diseases Pathology Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher D","family":"Paddock","sequence":"additional","affiliation":[{"name":"Rickettsial Zoonoses Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bobbi S","family":"Pritt","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott A","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy M","family":"Denison","sequence":"additional","affiliation":[{"name":"Infectious Diseases Pathology Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,4,6]]},"reference":[{"key":"2025092504090638000_70.10.891.1","first-page":"382","article-title":"A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissues","volume":"18","author":"Whipple","year":"1907","journal-title":"Bull Johns Hopkins Hosp"},{"key":"2025092504090638000_70.10.891.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199207303270501"},{"key":"2025092504090638000_70.10.891.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003023420903"},{"key":"2025092504090638000_70.10.891.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12597-4"},{"key":"2025092504090638000_70.10.891.5","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.3.561-583.2001"},{"key":"2025092504090638000_70.10.891.6","doi-asserted-by":"publisher","DOI":"10.3201\/eid1605.091801"},{"key":"2025092504090638000_70.10.891.7","doi-asserted-by":"publisher","DOI":"10.3201\/eid1602.090610"},{"key":"2025092504090638000_70.10.891.8","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.3201\/eid2207.150441","article-title":"Tropheryma whipplei as a cause of epidemic fever, Senegal, 2010\u20132012","volume":"22","author":"Bassene","year":"2016","journal-title":"Emerging Infect Dis"},{"key":"2025092504090638000_70.10.891.9","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2007\/011668-0"},{"key":"2025092504090638000_70.10.891.10","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.12.124"},{"key":"2025092504090638000_70.10.891.11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003538"},{"key":"2025092504090638000_70.10.891.12","doi-asserted-by":"publisher","DOI":"10.3201\/eid1806.111038"},{"key":"2025092504090638000_70.10.891.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2012.05.1033"},{"key":"2025092504090638000_70.10.891.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2014.05.008"},{"key":"2025092504090638000_70.10.891.15","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.14-0146"},{"key":"2025092504090638000_70.10.891.16","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1128\/JCM.38.2.595-599.2000","article-title":"Evaluation of a specific nested PCR targeting domain III of the 23s rRNA gene of \u201cTropheryma whippelii\u201d and proposal of a classification system for its molecular variants","volume":"38","author":"Hinrikson","year":"2000","journal-title":"J Clin Microbiol"},{"key":"2025092504090638000_70.10.891.17","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.7.3516-3518.2005"},{"key":"2025092504090638000_70.10.891.18","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(97)00314-X"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2017-204382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T11:09:13Z","timestamp":1758798553000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2017-204382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,6]]},"references-count":18,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,9,20]]},"published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1136\/jclinpath-2017-204382"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2017-204382","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[2017,4,6]]}}}