{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:51:04Z","timestamp":1763743864828,"version":"3.45.0"},"reference-count":18,"publisher":"BMJ","issue":"1","funder":[{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2017,5,8]]},"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>AIMS<\/jats:title>\n                    <jats:p>To analyse the effect of the expert end-point committee (EPC) review on histological endpoint classification of cervical intraepithelial neoplasia (CIN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cohort of women living with HIV were recruited in Burkina Faso (BF) and South Africa (SA) and followed over 18 months. Four-quadrant cervical biopsies were obtained in women with abnormalities detected by at least one screening test. A central review by a panel of five pathologists was organised at baseline and at endline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At baseline the prevalence of high-grade CIN (CIN2+) was 5.1% (28\/554) in BF and 23.3% (134\/574) in SA by local diagnosis, and 5.8% (32\/554) in BF and 22.5% (129\/574) in SA by the EPC. At endline the prevalence of CIN2+ was 2.3% (11\/483) in BF and 9.4% (47\/501) in SA by local diagnosis, and 1.4% (7\/483) in BF and 10.2% (51\/501) in SA by EPC. The prevalence of borderline CIN1\/2 cases was 2.8% (32\/1128) and 0.8% (8\/984) at baseline and endline. Overall agreement between local diagnosis and final diagnosis for distinguishing CIN2+ from \u2264CIN1 was 91.2% (\u03ba=0.82) and 88.9% (\u03ba=0.71) for BF at baseline and endline, and 92.7% (\u03ba=0.79) and 98.7% (\u03ba=0.97) for SA at baseline and endline. Among the CIN1\/2 cases, 12 (37.5%) were graded up to CIN2 and 20 (62.5%) were graded down to CIN1 at baseline, and 3 (37.5%) were graded up to CIN2 and 5 (62.5%) were graded down to CIN1 at endline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study highlights the importance of a centralised rigorous re-reading with exchange of experiences among pathologists from different settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2017-204512","type":"journal-article","created":{"date-parts":[[2017,6,9]],"date-time":"2017-06-09T21:08:37Z","timestamp":1497042517000},"page":"40-45","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Cervical intraepithelial neoplasia (CIN) in African women living with HIV: role and effect of rigorous histopathological review by a panel of pathologists in the HARP study endpoint determination"],"prefix":"10.1136","volume":"71","author":[{"given":"Sylviane","family":"Doutre","sequence":"first","affiliation":[{"name":"Department of Biology and Pathology, University Hospital (CHU), Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanvier","family":"Omar","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Health Laboratory Services Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Goumbri-Lompo","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Teaching Hospital Yalgado, Ouagadougou, Burkina Faso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, 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