{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:15:32Z","timestamp":1792556132357,"version":"4.5.0"},"reference-count":48,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2017,10,11]]},"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>Succinate dehydrogenase (SDH) is a heterotetrameric nuclear encoded mitochondrial protein complex which plays a role in the citric acid cycle and the electron transfer chain. Germline mutations in <jats:italic>SDHA<\/jats:italic> are associated with Leigh syndrome. Mutations in <jats:italic>SDHB<\/jats:italic>, <jats:italic>SDHC<\/jats:italic> and <jats:italic>SDHD<\/jats:italic> are found in an increasing number of neoplasms, most notably paragangliomas and wild-type gastrointestinal stromal tumours. SDH deficiency in these tumours has important prognostic implications, and also provides a novel target for molecular therapy. In this article, we outline the structure and function of SDH and provide a summary of its role in various diseases.<\/jats:p>","DOI":"10.1136\/jclinpath-2017-204677","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T20:40:27Z","timestamp":1508964027000},"page":"95-97","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":47,"title":["Gene of the month: SDH"],"prefix":"10.1136","volume":"71","author":[{"given":"Alessandro Pietro","family":"Aldera","sequence":"first","affiliation":[{"name":"Division of Anatomical Pathology, Faculty of Health Sciences, University of Cape Town and National Health Laboratory Service \u2013 Groote Schuur hospital, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhirendra","family":"Govender","sequence":"additional","affiliation":[{"name":"Division of Anatomical Pathology, Faculty of Health Sciences, University of Cape Town and 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