{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:35:22Z","timestamp":1773279322904,"version":"3.50.1"},"reference-count":31,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2017,10,18]]},"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To investigate the expression of major proteins related to primary neurodegenerative diseases and their prognostic significance in brains with Creutzfeldt-Jakob disease (CJD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and methods<\/jats:title>\n                  <jats:p>Thirty consecutive cases of confirmed CJD during the period 2010\u20132015 at Basque Brain bank were retrospectively reviewed. Moreover, major neurodegenerative-associated proteins (phosphorylated Tau, 4R tau, 3R tau, alpha-synuclein, TDP43, amyloid beta) were tested. Clinical data were reviewed. Cases were divided according to the presence or absence of copathology. Survival curves were also determined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Copathology was significantly associated with survival in brains with CJD (4.2\u00b11.2 vs 9.2\u00b11.9; P=0.019) and in brains with MM1\/MV1\u2009CJD (2.1\u00b11.0 vs 6.7\u00b12.8; P=0.012). Besides, the presence of more than one major neurodegenerative-associated protein was significantly associated with survival (4.2\u00b11.2 vs 10.7\u00b12.6; P=0.017). Thus, univariate analyses further pointed out variables significantly associated with better survival: copathology in CJD (HR=0.430; P=0.033); more than one neurodegenerative-associated protein in CJD (HR=0.369; P=0.036) and copathology in MM1\/MV1\u2009CJD (HR=0.525; P=0.032).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The existence of copathology significantly prolongs survival in patients with rapidly progressive dementia due to CJD. The study of major neurodegenerative-associated proteins in brains with CJD could allow us to further understand the molecular mechanisms behind prion diseases.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jclinpath-2017-204794","type":"journal-article","created":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T12:17:01Z","timestamp":1509625021000},"page":"446-450","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Brains with sporadic Creutzfeldt-Jakob disease and copathology showed a prolonged end-stage of disease"],"prefix":"10.1136","volume":"71","author":[{"given":"Aitzol","family":"Miguelez-Rodriguez","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Basque Country, Vitoria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Santos-Juanes","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Universitario 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