{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T12:46:58Z","timestamp":1775911618486,"version":"3.50.1"},"reference-count":17,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2017,12,7]]},"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Malaria is a potentially severe disease affecting nearly 200\u2009million people per year. Early detection of the parasite even in unsuspected patients remains the challenging aim for effective patient care. Automated complete blood counts that are usually performed for any febrile patient might represent a tool to ascertain malaria infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the ability of the new generation of the Sysmex hematology analyzer (XN-series) to detect malaria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively studied 100 blood samples performed with the recent Sysmex XN analyzer that were positive for\n                      <jats:italic>Plasmodium<\/jats:italic>\n                      and explored its ability to detect the parasite. 100 samples from patients uninfected by malaria were used as control group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Specific abnormalities such as additional events in the mature neutrophil\/eosinophil area of the white blood cells differential (WDF) scattergram were noted for 1.1% of\n                      <jats:italic>Plasmodium falciparum<\/jats:italic>\n                      samples and 56.2% of other\n                      <jats:italic>Plasmodium<\/jats:italic>\n                      species samples. Mature parasite stages (schizonts or gametocytes) were observed on blood smears among those samples. WDF scattergrams were able to detect 80.0% (12\/15) of\n                      <jats:italic>Plasmodium<\/jats:italic>\n                      mature stages. Furthermore, the differential in white blood counts between WDF and white cell nucleated (WNR) channels was a predictive signal of\n                      <jats:italic>Plasmodium<\/jats:italic>\n                      mature stages in 73.3% (11\/15) of samples and may be explained by a differential destruction of particles with the analyzer reagent.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Associated to thrombocytopaenia, a Sysmex XN\n                      <jats:italic>Plasmodium<\/jats:italic>\n                      pattern may represent a useful warning for\n                      <jats:italic>Plasmodium<\/jats:italic>\n                      detection in unsuspected patients, particularly when mature parasite stages are present.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2017-204878","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T12:18:21Z","timestamp":1514981901000},"page":"594-599","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Automated\n                    <i>Plasmodium<\/i>\n                    detection by the Sysmex XN hematology analyzer"],"prefix":"10.1136","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0462-2010","authenticated-orcid":false,"given":"C\u00e9cile","family":"Dumas","sequence":"first","affiliation":[{"name":"Service d\u2019H\u00e9matologie, Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Lise","family":"Bienvenu","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9matologie, Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon, France"},{"name":"Malaria Research Unit, University Lyon 1, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Girard","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9matologie, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Picot","sequence":"additional","affiliation":[{"name":"Malaria Research Unit, University Lyon 1, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gis\u00e8le","family":"Debize","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9matologie, Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Durand","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9matologie, Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,1,3]]},"reference":[{"key":"2025112110070089000_71.7.594.1","unstructured":"WHO. Overview of diagnostic testing. http:\/\/www.who.int\/malaria\/areas\/diagnosis\/overview\/en\/ (accessed 10 Jun 2017)."},{"key":"2025112110070089000_71.7.594.2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-008-0486-8"},{"key":"2025112110070089000_71.7.594.3","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2010.09-0560"},{"key":"2025112110070089000_71.7.594.4","doi-asserted-by":"publisher","DOI":"10.3343\/kjlm.2006.26.2.77"},{"key":"2025112110070089000_71.7.594.5","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/ijlh.12145","article-title":"Use of Sysmex XE-2100 and XE-5000 hematology analyzers for the diagnosis of malaria in a nonendemic country (France)","volume":"36","author":"Dubreuil","year":"2014","journal-title":"Int J Lab Hematol"},{"key":"2025112110070089000_71.7.594.6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1179\/1607845412Y.0000000029","article-title":"Abnormal WBC scattergram: a clue to the diagnosis of malaria","volume":"18","author":"Sharma","year":"2013","journal-title":"Hematology"},{"key":"2025112110070089000_71.7.594.7","doi-asserted-by":"crossref","DOI":"10.4084\/mjhid.2014.034","article-title":"Automated hematology analyzers in diagnosis of plasmodium vivax malaria: an adjunct to conventional microscopy","volume":"6","author":"Mubeen","year":"2014","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"2025112110070089000_71.7.594.8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/9286392","article-title":"Laboratory diagnosis of malaria: comparison of manual and automated diagnostic tests","volume":"2017","author":"Mukry","year":"2017","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"2025112110070089000_71.7.594.9","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2010.09-0464"},{"key":"2025112110070089000_71.7.594.10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01199.x"},{"key":"2025112110070089000_71.7.594.11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.2000.00327.x"},{"key":"2025112110070089000_71.7.594.12","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.12.4729-4731.2002"},{"key":"2025112110070089000_71.7.594.13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.2004.00648.x"},{"key":"2025112110070089000_71.7.594.14","unstructured":"Centre National de R\u00e9f\u00e9rence du Paludisme pour la France m\u00e9tropolitaine. Rapport annueld\u2019activit\u00e9. Paris, France: Centre National de R\u00e9f\u00e9rence du Paludisme pour la France m\u00e9tropolitaine, 2015. http:\/\/cnrpaludisme-france.org\/docs\/rapport_activites_cnr_paludisme_2014.pdf. 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