{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:41:53Z","timestamp":1790509313750,"version":"4.1.0"},"reference-count":15,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2018,8,16]]},"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>\n                    Cutaneous melanoma causes most of the skin cancer deaths in the USA. Melanoma is the fifth most common cancer among men and the sixth most common cancer among women. The incidence of melanoma has risen sharply over the past three decades. In this review, which is informed by our extensive experience at a large cancer centre, we outline the key differences between the tumour, node and metastases staging criteria for cutaneous melanoma in the seventh and eighth editions of the\n                    <jats:italic>AJCC Cancer Staging Manual<\/jats:italic>\n                    . We also offer advice on how to assess the histophenotypic parameters that are relevant for staging, with a special focus on avoiding potential pitfalls, and how to report all the prognostically and therapeutically relevant histophenotypic parameters. Correct assessment and reporting of these clinically relevant histophenotypic parameters is of outmost importance for practising pathologists because these parameters help treating clinicians select the most appropriate personalised treatment for patients in this era of promising targeted and immunotherapies.\n                  <\/jats:p>","DOI":"10.1136\/jclinpath-2018-205417","type":"journal-article","created":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T12:15:20Z","timestamp":1538396120000},"page":"265-270","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Update on eighth edition American Joint Committee on Cancer classification for cutaneous melanoma and overview of potential pitfalls in histological examination of staging parameters"],"prefix":"10.1136","volume":"72","author":[{"given":"Celestine M","family":"Trinidad","sequence":"first","affiliation":[{"name":"Dermatopathology Section, Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A","family":"Torres-Cabala","sequence":"additional","affiliation":[{"name":"Dermatopathology Section, Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L","family":"Curry","sequence":"additional","affiliation":[{"name":"Dermatopathology Section, Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor G","family":"Prieto","sequence":"additional","affiliation":[{"name":"Dermatopathology Section, Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3398-0573","authenticated-orcid":false,"given":"Phyu P","family":"Aung","sequence":"additional","affiliation":[{"name":"Dermatopathology Section, Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,10,1]]},"reference":[{"key":"2025121323021227000_72.4.265.1","unstructured":"National Cancer Institute, DCCPS, Surveillance Research Program . Cancer STAT facts: Melanoma of the skin. 2017. Available: https:\/\/seer.cancer.gov\/statfacts\/html\/melan.html"},{"key":"2025121323021227000_72.4.265.2","unstructured":"World cancer research fund international . Cancer data - worldwide trends. 2018. Available: https:\/\/www.wcrf.org\/int\/cancer-facts-figures\/worldwide-data"},{"key":"2025121323021227000_72.4.265.3","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15510"},{"key":"2025121323021227000_72.4.265.4","article-title":"US Department of Health and Human Services. Surveillance, Epidemiology, and End Results (SEER) Program Populations (2007-2013)","year":"2013"},{"key":"2025121323021227000_72.4.265.5","unstructured":"Gershenwald JE , Scolyer RA , Hess KR . Melanoma of the skin. In: Amin AB , Edge SB , Greene FL , et al , eds. AJCC Cancer Staging Manual. 8th Ed. New York: Springer, 2017: 563\u201385."},{"key":"2025121323021227000_72.4.265.6","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21409"},{"key":"2025121323021227000_72.4.265.7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.4799"},{"key":"2025121323021227000_72.4.265.8","unstructured":"Balch CM , Soong SJ , Gershenwald JE , et al . Melanoma of the skin. In: Edge S , Byrd D , Compton C , et al , eds. AJCC Cancer Staging Manual. 7th edn. edn. New York: Springer Verlag, 2009: 325\u201344."},{"key":"2025121323021227000_72.4.265.9","unstructured":"Edge SB , Byrd DR , Compton CC . AJCC cancer staging manual 7th edn. New York: Springer, 2010."},{"key":"2025121323021227000_72.4.265.10","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.5812"},{"key":"2025121323021227000_72.4.265.11","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31829d7f35"},{"key":"2025121323021227000_72.4.265.12","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25634"},{"key":"2025121323021227000_72.4.265.13","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605622"},{"key":"2025121323021227000_72.4.265.14","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1002\/cncr.25634","article-title":"Prognostic factors for survival in melanoma patientswith brain metastases","volume":"117","author":"Davies","year":"2011","journal-title":"Cancer"},{"key":"2025121323021227000_72.4.265.15","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/sj.bjc.6605622","article-title":"Determinants of survival in patients with brainmetastases from cutaneous melanoma","volume":"102","author":"Staudt","year":"2010","journal-title":"Br J Cancer"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2018-205417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T07:02:18Z","timestamp":1765695738000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2018-205417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,1]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,3,20]]},"published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1136\/jclinpath-2018-205417"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2018-205417","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,1]]}}}