{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T10:51:25Z","timestamp":1786963885810,"version":"build-2736575974"},"reference-count":33,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2019,6,28]]},"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The purpose of the present study was to elucidate the presence of human herpesvirus 6A (HHV-6A), HHV-6B and HHV-7 in samples of the uterine cervix through detection of viral DNA. We analysed normal tissues, samples with low-grade squamous intraepithelial lesions (LSILs) and high-grade squamous intraepithelial lesions (HSILs). We correlated the presence of HHV-6 and HHV-7 with the finding of human papillomavirus (HPV) in mucosal samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cervical samples were examined and grouped as follows: group 1 (n=29), normal cytology; group 2 (n=61), samples with LSIL; group 3 (n=35), samples with HSIL. Molecular biology examinations were performed in all samples to detect HHV-6, HHV-7 and HPV DNA and to typify HHV-6 species.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Group 1: normal cytology and HPV (\u2212): HHV-6: 6.8% (2\/29), HHV-7: 79.3% (23\/29); group 2: LSIL and HPV (\u2212): HHV-6: 93.1% (27\/29), HHV-7: 96.5% (28\/29); LSIL and HPV (+): HHV-6: 0% (0\/32), HHV-7: 90.6% (29\/32); group 3: HSIL and HPV (\u2212): HHV-6: 20% (2\/10), HHV-7: 70% (7\/10); HSIL HPV (+): HHV-6: 12% (3\/25), HHV-7: 68% (17\/25). HHV-6A DNA was not detected in any samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>(1) Both HHV-6 and HHV-7 infect the mucosal cells of the cervix with higher prevalence of HHV-7. (2) The higher prevalence of HHV-6 in LSIL HPV (\u2212) samples compared with those with normal cytology indicates that it constitutes a possible risk factor for atypia production. (3) The presence of HHV-7 in all samples questions its role in the production of atypia. (4) The finding of HHV-6 and HHV-7 suggests that the cervical mucosa is a possible transmission pathway for these viruses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2019-205795","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T17:19:23Z","timestamp":1563383963000},"page":"30-34","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Detection of human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) DNA in endocervical samples from a positive and negative HPV woman of C\u00f3rdoba, Argentina"],"prefix":"10.1136","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4902-6813","authenticated-orcid":false,"given":"Patricia","family":"Biganzoli","sequence":"first","affiliation":[{"name":"Virology Institute \u2018Dr. J. Vanella\u2019, School of Medical Sciences, National University of C\u00f3rdoba, Cordoba, Cordoba, Argentina"},{"name":"Medical Bacteriology and Virology, School of Medical Sciences, National University of C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Celia","family":"Frutos","sequence":"additional","affiliation":[{"name":"Virology Institute \u2018Dr. J. Vanella\u2019, School of Medical Sciences, National University of C\u00f3rdoba, Cordoba, Cordoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Venezuela","sequence":"additional","affiliation":[{"name":"Virology Institute \u2018Dr. J. Vanella\u2019, School of Medical Sciences, National University of C\u00f3rdoba, Cordoba, Cordoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Mosmann","sequence":"additional","affiliation":[{"name":"Virology Institute \u2018Dr. J. 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