{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:28:10Z","timestamp":1792787290947,"version":"4.5.0"},"reference-count":21,"publisher":"BMJ","issue":"8","funder":[{"name":"Yaoli chen","award":["Science and Research Foundation of Peking Universi"],"award-info":[{"award-number":["Science and Research Foundation of Peking Universi"]}]},{"name":"Yuhua Huang","award":["Medical Science and Technology Foundation of Guang"],"award-info":[{"award-number":["Medical Science and Technology Foundation of Guang"]}]},{"name":"Yuhua Huang","award":["Natural Science Foundation of Guangdong Province \/"],"award-info":[{"award-number":["Natural Science Foundation of Guangdong Province \/"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2019,5,29]]},"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Although ultrastructural studies showed that minute pulmonary meningothelial-like nodules (MPMNs) cells closely resembled meningothelial cells, their immunophenotype has not been well characterised, partly due to their rarity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Somatostatin receptor 2a (SSTR2a) and other markers of meningioma, including epithelial membrane antigen (EMA), progesterone receptor (PR) and S100, were analysed retrospectively in 19 MPMN cases from two institutions in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median age of patients with MPMNs was 62.5 years (32\u201373 years), with a male-to-female ratio of 1:8.5. Most (15\/19) patients with MPMNs had coexisting diseases, including adenocarcinomas (12 cases), bronchiectasis (1 case) and tuberculosis (2 cases). Just over half of the cases (10\/19) were multifocal lesions (2\u20135 lesions). An additional 53 cases with 123 lesions from the literature were reviewed with reported immunophenotype information. In total, 162 lesions were included in the analysis. The size of nodules was 1\u20134\u2009mm. All MPMN lesions (39\/39) in the 19 cases showed strong and diffuse cytoplasmic expression of SSTR2a. The expression rate of SSTR2a was higher than that of conventional markers of meningioma, including EMA (86\/138), PR (32\/68) and S100 (1\/125).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our observations expand the spectrum of recognised SSTR2a-positive lesions and once again demonstrated that MPMNs show immunohistochemical characteristics similar to meningothelial cells.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2019-205913","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T17:15:35Z","timestamp":1560791735000},"page":"525-528","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Constant expression of somatostatin receptor 2a in minute pulmonary meningothelial-like nodules"],"prefix":"10.1136","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4976-4266","authenticated-orcid":false,"given":"LiLi","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Pathology, Peking University Shenzhen Hospital, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoli","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Peking University Shenzhen Hospital, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qitao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou, China"},{"name":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Yong","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ShuMei","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou, China"},{"name":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou, China"},{"name":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,6,17]]},"reference":[{"key":"2025092612203738000_72.8.525.1","first-page":"641","article-title":"Multiple minute pulmonary tumors resembling chemodectomas","volume":"37","author":"Korn","year":"1960","journal-title":"Am J Pathol"},{"key":"2025092612203738000_72.8.525.2","first-page":"1158","article-title":"Intrapulmonary chemodectomas in subjects with organizing pulmonary thromboemboli","volume":"96","author":"Spain","year":"1967","journal-title":"Am Rev Respir Dis"},{"key":"2025092612203738000_72.8.525.3","first-page":"17a","article-title":"Some histochemical tests in Zak\u2019s chemoblastomatosis","volume":"44","author":"Barrcso-Moguel","year":"1964","journal-title":"Am J Pathol"},{"key":"2025092612203738000_72.8.525.4","first-page":"351","article-title":"Pleural origin of some of the supposed chemodectoid structures of the lung","volume":"146","author":"Costero","year":"1972","journal-title":"BeitragezurPathologie"},{"key":"2025092612203738000_72.8.525.5","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0046-8177(75)80077-3","article-title":"The fine structure of so-called minute pulmonary chemodectomas","volume":"6","author":"Kuhn","year":"1975","journal-title":"Human Pathology"},{"key":"2025092612203738000_72.8.525.6","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1002\/1097-0142(197604)37:4<1759::AID-CNCR2820370422>3.0.CO;2-3","article-title":"So-called \u201cminute pulmonary chemodectoma\u201d.A tumor not related to paragangliomas","volume":"37","author":"Churg","year":"1976","journal-title":"Cancer"},{"key":"2025092612203738000_72.8.525.7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/00000478-198803000-00001","article-title":"Minute pulmonary meningothelial-like nodules: a clinicopathologic study of so-called minute pulmonary chemodectoma","volume":"12","author":"Gaffey","year":"1988","journal-title":"Am J Surg Pathol"},{"key":"2025092612203738000_72.8.525.8","doi-asserted-by":"crossref","unstructured":"Travis WD , Colby TV , Corrin B , et al . 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