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In 39 (12%) the discrepancy was in overall diagnosis, including 22 (7%) in which the local diagnosis was low-grade appendiceal mucinous neoplasm whereas the review diagnosis was reactive mucosal changes, usually due to ruptured diverticulum, with no evidence of neoplasia. Our findings support the practice of central review of histopathology slides by experienced pathologists at tertiary referral centres. They also suggest that improvements in diagnostic criteria are needed.<\/jats:p>","DOI":"10.1136\/jclinpath-2019-205945","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T17:15:18Z","timestamp":1560964518000},"page":"639-641","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Diagnostic concordance in cases of appendiceal mucinous neoplasia referred to a tertiary referral centre"],"prefix":"10.1136","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9318-2178","authenticated-orcid":false,"given":"Aliasger","family":"Amin","sequence":"first","affiliation":[{"name":"Peritoneal Malignancy Unit, Basingstoke and North Hampshire NHS Foundation Trust, Basingstoke, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5087-6874","authenticated-orcid":false,"given":"Norman","family":"Carr","sequence":"additional","affiliation":[{"name":"Peritoneal Malignancy Unit, Basingstoke and North Hampshire NHS Foundation Trust, Basingstoke, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,6,19]]},"reference":[{"key":"2025120521193311000_72.9.639.1","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/his.13324","article-title":"The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei","volume":"71","author":"Carr","year":"2017","journal-title":"Histopathology"},{"key":"2025120521193311000_72.9.639.2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/BF02236899","article-title":"Appendiceal tumors","volume":"41","author":"Connor","year":"1998","journal-title":"Diseases of the Colon & Rectum"},{"key":"2025120521193311000_72.9.639.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2007.04.002"},{"key":"2025120521193311000_72.9.639.4","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1007\/s10350-007-9033-2","article-title":"Four percent of patients undergoing colorectal cancer surgery may have synchronous appendiceal neoplasia","volume":"50","author":"Khan","year":"2007","journal-title":"Diseases of the Colon & Rectum"},{"key":"2025120521193311000_72.9.639.5","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1097\/DCR.0b013e3182a62b0d","article-title":"Complete cytoreduction for pseudomyxoma peritonei is optimal but maximal tumor debulking may be beneficial in patients in whom complete tumor removal cannot be achieved","volume":"56","author":"Dayal","year":"2013","journal-title":"Diseases of the Colon & Rectum"},{"key":"2025120521193311000_72.9.639.6","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.5858\/arpa.2011-0034-RA","article-title":"Mucinous neoplasms of the appendix and peritoneum","volume":"135","author":"Panarelli","year":"2011","journal-title":"Archives of Pathology & Laboratory Medicine"},{"key":"2025120521193311000_72.9.639.7","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000535"},{"key":"2025120521193311000_72.9.639.8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.7166"},{"key":"2025120521193311000_72.9.639.9","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/bjs.8739","article-title":"Classification of and cytoreductive surgery for low-grade appendiceal mucinous neoplasms","volume":"99","author":"McDonald","year":"2012","journal-title":"British Journal of Surgery"},{"key":"2025120521193311000_72.9.639.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2005.12.003"},{"key":"2025120521193311000_72.9.639.11","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31817f1816"},{"key":"2025120521193311000_72.9.639.12","unstructured":"Stephenson TJ , Cross SS , Chetty R . Dataset for neuroendocrine tumours of the gastrointestinal tract including pancreas. 3th edn. London: The Royal College of Pathologists, 2012."},{"key":"2025120521193311000_72.9.639.13","first-page":"105","article-title":"Nonneoplastic mimics of appendiceal mucinous neoplasms","volume":"24","author":"Misdraji","year":"2019","journal-title":"AJSP: Reviews & Reports"},{"key":"2025120521193311000_72.9.639.14","doi-asserted-by":"crossref","unstructured":"Valasek MA , Thung I , Gollapalle E , et al . Overinterpretation is common in pathological diagnosis of appendix cancer during patient referral for oncologic care. 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