{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T19:40:11Z","timestamp":1758915611278,"version":"3.44.0"},"reference-count":32,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2019,8,29]]},"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To describe and investigate the potential causes of the isolated caecal patch lesion, a previously undescribed endoscopic phenomenon of a lesion fulfilling endoscopic and histopathological criteria for chronic inflammatory bowel disease but without evidence of similar inflammatory pathology elsewhere at colonoscopy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Cases were collected prospectively by one specialist gastrointestinal pathologist over a 10-year period. Full endoscopic and histopathological analysis was undertaken and follow-up sought to understand the likely cause(s) of the lesions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Six cases are described. Two had very close links with ulcerative colitis, one predating the onset of classical distal disease and the other occurring after previous demonstration of classical distal ulcerative colitis. Two occurred in younger patients and we postulate that these lesions may predict the subsequent onset of chronic inflammatory bowel disease. Finally two can be reasonably attributed to the effects of non-steroidal inflammatory agent therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Caecal patch lesions can be demonstrated in isolation. Despite the strong association of caecal patch lesions with ulcerative colitis, solitary lesions may well have disparate causes but nevertheless possess a close relationship with chronic inflammatory bowel disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jclinpath-2019-206146","type":"journal-article","created":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T17:27:00Z","timestamp":1569432420000},"page":"121-125","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["The isolated caecal patch lesion: a clinical, endoscopic and histopathological study"],"prefix":"10.1136","volume":"73","author":[{"given":"Anju","family":"Ekanayaka","sequence":"first","affiliation":[{"name":"Gloucestershire Cellular Pathology Laboratory, Cheltenham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Cheltenham General Hospital, Cheltenham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele E","family":"Lucarotti","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Gloucestershire Royal Hospital, Gloucester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland M","family":"Valori","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Gloucestershire Royal Hospital, Gloucester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4228-6580","authenticated-orcid":false,"given":"Neil A","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Gloucestershire Cellular Pathology Laboratory, Cheltenham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,9,25]]},"reference":[{"key":"2025092611584252000_73.3.121.1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2013-201885"},{"issue":"5 Suppl 1","key":"2025092611584252000_73.3.121.2","first-page":"511","article-title":"The histopathological approach to inflammatory bowel disease: a practice guide","volume":"4","author":"Langner","year":"2014","journal-title":"Virchows Arch"},{"key":"2025092611584252000_73.3.121.3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1365-2559.1990.tb01069.x","article-title":"The appendix as a 'skip lesion' in ulcerative colitis","volume":"16","author":"Davison","year":"1990","journal-title":"Histopathology"},{"key":"2025092611584252000_73.3.121.4","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3129-z"},{"key":"2025092611584252000_73.3.121.5","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.6.801"},{"key":"2025092611584252000_73.3.121.6","doi-asserted-by":"publisher","DOI":"10.1080\/0031302021000035974"},{"key":"2025092611584252000_73.3.121.7","first-page":"1275","article-title":"Patchy cecal inflammation associated with distal ulcerative colitis: a prospective endoscopic study","volume":"92","author":"D'Haens","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"2025092611584252000_73.3.121.8","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510023305"},{"key":"2025092611584252000_73.3.121.9","first-page":"58","article-title":"Clinical significance of isolated peri-appendiceal lesions in patients with left sided ulcerative colitis","volume":"4","author":"Katz","year":"2011","journal-title":"Gastroenterol Res"},{"key":"2025092611584252000_73.3.121.10","doi-asserted-by":"crossref","unstructured":"Feakins RM , Shepherd NA . 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