{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T06:55:33Z","timestamp":1765695333650,"version":"3.48.0"},"reference-count":27,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2019,10,14]]},"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      The aim of this study was to evaluate the mismatch repair gene expression and their correlation with\n                      <jats:italic>NF-kB<\/jats:italic>\n                      in patients with oral squamous cell carcinoma (SCC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Total RNA was isolated from 28 biopsy samples. A control group was composed of 20 volunteers. Differential expression of\n                      <jats:italic>hMSH2<\/jats:italic>\n                      ,\n                      <jats:italic>hMSH6<\/jats:italic>\n                      and\n                      <jats:italic>NF-kB<\/jats:italic>\n                      genes was accessed by quantitative PCR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There is increased expression of all the analysed genes when the patients were smokers and alcoholics. In addition, there is increased expression of\n                      <jats:italic>hMSH2<\/jats:italic>\n                      when SCC was removed from the base of the tongue. There was a correlation between\n                      <jats:italic>NF-kB<\/jats:italic>\n                      and\n                      <jats:italic>hMSH2<\/jats:italic>\n                      and\n                      <jats:italic>hMSH6<\/jats:italic>\n                      as well as between repair genes\n                      <jats:italic>hMSH2<\/jats:italic>\n                      and\n                      <jats:italic>hMSH6<\/jats:italic>\n                      expression levels. There is increased expression of the\n                      <jats:italic>hMSH2<\/jats:italic>\n                      gene in patients with SCC, especially in the alcoholics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      There is a strong indication that\n                      <jats:italic>NF-kB<\/jats:italic>\n                      gene was expressed along with the studied repair genes, evidencing the possibility that this system can be activated by the inflammatory pathway.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2019-206161","type":"journal-article","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T17:27:08Z","timestamp":1572370028000},"page":"273-277","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Expression of MMR system genes is correlated to NF-kB in patients with oral squamous cell carcinoma"],"prefix":"10.1136","volume":"73","author":[{"given":"Alexandre","family":"Fonseca","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de An\u00e1lises Cl\u00ednicas, Centro Universit\u00e1rio Sa\u00fade ABC\/Faculdade de Medicina do ABC, Santo Andre, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus","family":"Perez","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de An\u00e1lises Cl\u00ednicas, Centro Universit\u00e1rio Sa\u00fade ABC\/Faculdade de Medicina do ABC, Santo Andre, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glaucia","family":"Veiga","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de An\u00e1lises Cl\u00ednicas, Centro Universit\u00e1rio Sa\u00fade ABC\/Faculdade de Medicina do ABC, Santo Andre, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio","family":"Prosd\u00f3cimi","sequence":"additional","affiliation":[{"name":"Universidade Paulista, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Nunes","sequence":"additional","affiliation":[{"name":"Faculdade de Odontologia, Universidade de S\u00e3o Paulo, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca","family":"Bianco","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de An\u00e1lises Cl\u00ednicas, Centro Universit\u00e1rio Sa\u00fade ABC\/Faculdade de Medicina do ABC, Santo Andre, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de An\u00e1lises Cl\u00ednicas, Centro Universit\u00e1rio Sa\u00fade ABC\/Faculdade de Medicina do ABC, Santo Andre, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9930-7747","authenticated-orcid":false,"given":"Beatriz","family":"Alves","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de An\u00e1lises Cl\u00ednicas, Centro Universit\u00e1rio Sa\u00fade ABC\/Faculdade de Medicina do ABC, Santo Andre, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,10,29]]},"reference":[{"key":"2025121322542694000_73.5.273.1","first-page":"11884","article-title":"Essentials of oral cancer","volume":"8","author":"Rivera","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"2025121322542694000_73.5.273.2","unstructured":"National Institutes of Health (NIH) . National cancer Institute. lip and oral cavity cancer treatment. USA, 2018 [Accessed 05 may 2018]."},{"key":"2025121322542694000_73.5.273.3","first-page":"645","article-title":"Global incidence and risk factors of oral cancer","volume":"156","author":"Ghantous","year":"2017","journal-title":"Harefuah"},{"key":"2025121322542694000_73.5.273.4","doi-asserted-by":"crossref","first-page":"239","DOI":"10.5935\/1808-8694.20130041","article-title":"Head and neck cancer: causes, prevention and treatment","volume":"79","author":"Galbiatti","year":"2013","journal-title":"Braz J Otorhinolaryngol"},{"key":"2025121322542694000_73.5.273.5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.7662"},{"key":"2025121322542694000_73.5.273.6","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21421"},{"key":"2025121322542694000_73.5.273.7","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt635"},{"key":"2025121322542694000_73.5.273.8","doi-asserted-by":"publisher","DOI":"10.1667\/RR13515.1"},{"key":"2025121322542694000_73.5.273.9","doi-asserted-by":"crossref","DOI":"10.3390\/genes9010024","article-title":"Nf-kappaB: two sides of the same coin","volume":"9","author":"Pires","year":"2018","journal-title":"Genes"},{"key":"2025121322542694000_73.5.273.10","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11845-016-1464-0","article-title":"From inflammation to cancer","volume":"186","author":"Korniluk","year":"2017","journal-title":"Ir J Med Sci"},{"key":"2025121322542694000_73.5.273.11","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp127"},{"key":"2025121322542694000_73.5.273.12","first-page":"600","article-title":"RNA isolation from paraffinated material of histological\u2019s prepared slides","volume":"5","author":"Perez","year":"2017","journal-title":"MicroMed"},{"key":"2025121322542694000_73.5.273.13","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.9.e45"},{"key":"2025121322542694000_73.5.273.14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4103\/0973-1482.147380","article-title":"The effects of combination of gefitinib and cisplatin on tongue squamous cell carcinoma cell lines","volume":"11","author":"Helal","year":"2015","journal-title":"J Cancer Res Ther"},{"key":"2025121322542694000_73.5.273.15","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.4.110807.092158"},{"key":"2025121322542694000_73.5.273.16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/ecosalplus.7.2.5","article-title":"DNA mismatch repair","volume":"5","author":"Marinus","year":"2012","journal-title":"EcoSal Plus"},{"key":"2025121322542694000_73.5.273.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2009.11.005"},{"key":"2025121322542694000_73.5.273.18","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21140"},{"key":"2025121322542694000_73.5.273.19","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000003725","article-title":"Overexpression of MutS\u03b1 complex proteins predicts poor prognosis in oral squamous cell carcinoma","volume":"95","author":"Wagner","year":"2016","journal-title":"Medicine"},{"key":"2025121322542694000_73.5.273.20","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk179"},{"key":"2025121322542694000_73.5.273.21","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1590\/1980-5497201500030008","article-title":"Factors associated with lip and oral cavity cancer","volume":"18","author":"Ribeiro","year":"2015","journal-title":"Rev Bras Epidemiol"},{"key":"2025121322542694000_73.5.273.22","unstructured":"Instituto Nacional de C\u00e2ncer (INCA) . Coordena\u00e7\u00e3o de Preven\u00e7\u00e3o E Vigil\u00e2ncia. Estimativa incid\u00eancia de c\u00e2ncer no Brasil. Rio de Janeiro: INCA, 2018: 128."},{"key":"2025121322542694000_73.5.273.23","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1590\/S1516-44462000000100008","article-title":"The role of the transcription factor NF-kB in the molecular mechanisms of action of psychoactive drugs","volume":"22","author":"Glezer","year":"2000","journal-title":"Rev Bras Psiquiatr"},{"key":"2025121322542694000_73.5.273.24","first-page":"182","article-title":"Analysis of the prevalence of squamous cell carcinoma of the oral cavity in the stomatology service of hospital Metropolitano Odilon Behrens in Belo Horizonte, Minas Gerais, Brazil","volume":"52","author":"Deusdedit","year":"2016","journal-title":"Arq Odontol"},{"key":"2025121322542694000_73.5.273.25","first-page":"2433","article-title":"Tobacco and inflammation effects in immunoexpression of hMSH2 and hMLH1 in epithelium of oral mucosa","volume":"27","author":"Fernandes","year":"2007","journal-title":"Anticancer Res"},{"key":"2025121322542694000_73.5.273.26","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3923\/ijbc.2011.291.299","article-title":"Revisiting the pathology of nuclear factor kappa beta","volume":"5","author":"Paniago","year":"2011","journal-title":"Int J Biol Chem"},{"key":"2025121322542694000_73.5.273.27","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.soc.2009.07.007","article-title":"Role of MSH6 and pms2 in the DNA mismatch repair process and carcinogenesis","volume":"18","author":"Jenkins","year":"2009","journal-title":"Surg Oncol Clin N Am"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2019-206161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T06:54:34Z","timestamp":1765695274000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2019-206161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,29]]},"references-count":27,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,4,20]]},"published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1136\/jclinpath-2019-206161"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2019-206161","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[2019,10,29]]}}}