{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T06:10:44Z","timestamp":1765692644585,"version":"3.48.0"},"reference-count":13,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2019,9,23]]},"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Acellular intra-abdominal mucin is associated with a favourable prognosis in pseudomyxoma peritonei. There are no current guidelines on how many blocks are needed to classify the mucin as acellular with confidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Specimens from cytoreductive surgery for mucinous appendiceal neoplasia, in which acellular mucin was found on initial histopathological examination, were prospectively identified. Additional tissue blocks were then taken to include either all residual visible intra-abdominal mucin or a maximum of 30 blocks. We also sent a questionnaire to pathologists in other centres.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twelve patients were identified. In two cases, neoplastic epithelial cells were found on taking additional blocks. The questionnaire results suggested considerable variation in block-taking practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Taking additional tissue identified neoplastic cells in 2 of 12 cases. We recommend that sampling additional material should be considered when only acellular mucin is found on initial histology. Further work to determine the optimum sampling protocol is indicated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2019-206213","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T07:55:14Z","timestamp":1571039714000},"page":"220-222","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Acellular mucin in pseudomyxoma peritonei of appendiceal origin: what is adequate sampling for histopathology?"],"prefix":"10.1136","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2220-4835","authenticated-orcid":false,"given":"Marwa","family":"Al-Azzawi","sequence":"first","affiliation":[{"name":"Department of Surgery, Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Misdraji","sequence":"additional","affiliation":[{"name":"Depatment of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Louise F","family":"van Velthuysen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Erasmus Medical Centre, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinru","family":"Shia","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa W","family":"Taggart","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhonda K","family":"Yantiss","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York city, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magali","family":"Svrcek","sequence":"additional","affiliation":[{"name":"Department of Pathology, H\u00f4pital Saint-Antoine, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman","family":"Carr","sequence":"additional","affiliation":[{"name":"Department of Pathology, Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,10,13]]},"reference":[{"key":"2025121322074368000_73.4.220.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1055-3207(03)00026-7"},{"key":"2025121322074368000_73.4.220.2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.4251\/wjgo.v2.i1.44","article-title":"Pseudomyxoma peritonei.","volume":"2","author":"Bevan","year":"2010","journal-title":"World J Gastrointest 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Uicc (Union for international cancer control) TNM classification of malignant tumours. 8th edn. Oxford: John Wiley & Sons, 2017: 70\u20132."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2019-206213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T06:07:51Z","timestamp":1765692471000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2019-206213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,13]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,3,20]]},"published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1136\/jclinpath-2019-206213"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2019-206213","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[2019,10,13]]}}}