{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:25:36Z","timestamp":1791912336649,"version":"4.3.4"},"reference-count":24,"publisher":"BMJ","issue":"6","license":[{"start":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T00:00:00Z","timestamp":1576022400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Roche Molecular Systems, Inc.","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2019,10,31]]},"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Point-of-care (POC) tests for influenza and respiratory syncytial virus (RSV) offer the potential to improve patient management and antimicrobial stewardship. Studies have focused on performance; however, no workflow assessments have been published comparing POC molecular tests. This study compared the Liat and ID Now systems workflow, to assist end-users in selecting an influenza and\/or RSV POC test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Staffing, walk-away and turnaround time (TAT) of the Liat and ID Now systems were determined using 40 nasopharyngeal samples, positive for influenza or RSV. The ID Now system requires separate tests for influenza and RSV, so parallel (two instruments) and sequential (one instrument) workflows were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The ID Now ranged 4.1\u20136.2 min for staffing, 1.9\u201310.9 min for walk-away and 6.4\u201315.8 min for TAT per result. The Liat ranged 1.1\u20131.8 min for staffing, 20.0\u201320.5 min for walk-away and 21.3\u201322.0 min for TAT. Mean walk-away time comprised 38.0% (influenza positive) and 68.1% (influenza negative) of TAT for ID Now and 93.7% (influenza\/RSV) for Liat. The ID Now parallel workflow resulted in medians of 5.9 min for staffing, 9.7 min for walk-away and 15.6 min for TAT. Assuming prevalence of 20% influenza and 20% RSV, the ID Now sequential workflow resulted in medians of 9.4 min for staffing, 17.4 min for walk-away, and 27.1 min for TAT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The ID Now and Liat systems offer different workflow characteristics. Key considerations for implementation include value of both influenza and RSV results, clinical setting, staffing capacity, and instrument(s) placement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2019-206242","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T17:15:33Z","timestamp":1576084533000},"page":"328-334","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Molecular point-of-care testing for influenza A\/B and respiratory syncytial virus: comparison of workflow parameters for the ID Now and cobas Liat systems"],"prefix":"10.1136","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0376-6138","authenticated-orcid":false,"given":"Stephen","family":"Young","sequence":"first","affiliation":[{"name":"Department of Pathology, University of New Mexico, Albuquerque, New Mexico, USA"},{"name":"TriCore Reference Laboratories, Albuquerque, New Mexico, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Phillips","sequence":"additional","affiliation":[{"name":"Roche Diagnostics Corp, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christen","family":"Griego-Fullbright","sequence":"additional","affiliation":[{"name":"TriCore Reference Laboratories, Albuquerque, New Mexico, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Wagner","sequence":"additional","affiliation":[{"name":"TriCore Reference Laboratories, Albuquerque, New Mexico, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Jim","sequence":"additional","affiliation":[{"name":"TriCore Reference Laboratories, Albuquerque, New Mexico, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheena","family":"Chaudhuri","sequence":"additional","affiliation":[{"name":"Roche Molecular Systems Inc, Pleasanton, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaowu","family":"Tang","sequence":"additional","affiliation":[{"name":"Roche Molecular Systems Inc, Pleasanton, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Sickler","sequence":"additional","affiliation":[{"name":"Roche Molecular Systems Inc, Pleasanton, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,12,11]]},"reference":[{"key":"2025120619121126000_73.6.328.1","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S1473-3099(18)30310-4","article-title":"Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990-2016: a systematic analysis for the global burden of disease study 2016","volume":"18","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"2025120619121126000_73.6.328.2","unstructured":"World Health Organization . Influenza (seasonal) fact sheet, 2018. Available: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/influenza-(seasonal)"},{"key":"2025120619121126000_73.6.328.3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S2213-2600(18)30496-X","article-title":"Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017: an analysis for the global burden of disease study 2017","volume":"7","year":"2019","journal-title":"Lancet Respir Med"},{"key":"2025120619121126000_73.6.328.4","unstructured":"Centers for Disease Control and Prevention . Respiratory Syncytial Virus Infection (RSV), 2018. Available: https:\/\/www.cdc.gov\/rsv\/index.html"},{"key":"2025120619121126000_73.6.328.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30938-8"},{"key":"2025120619121126000_73.6.328.6","doi-asserted-by":"crossref","unstructured":"Shi T , Denouel A , Tietjen AK , et al . 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San Francisco, CA, USA, 2018.","DOI":"10.1093\/ofid\/ofy210.753"},{"key":"2025120619121126000_73.6.328.9","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/cid\/ciy991","article-title":"Severe morbidity and mortality associated with respiratory syncytial virus versus influenza infection in hospitalized older adults","volume":"69","author":"Ackerson","year":"2019","journal-title":"Clin Infect Dis"},{"key":"2025120619121126000_73.6.328.10","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.jhin.2018.03.034","article-title":"Respiratory syncytial virus burden among adults during flu season: an underestimated pathology","volume":"100","author":"Kestler","year":"2018","journal-title":"J Hosp Infect"},{"key":"2025120619121126000_73.6.328.11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0214517","article-title":"Characteristics of hospitalized adult patients with laboratory documented Influenza A, B and Respiratory Syncytial Virus - A single center retrospective observational study","volume":"14","author":"Cohen","year":"2019","journal-title":"PLoS One"},{"key":"2025120619121126000_73.6.328.12","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1002\/jmv.25462","article-title":"Respiratory syncytial virus infection among adults during influenza season: a frequently overlooked diagnosis","volume":"91","author":"Mart\u00ednez-Sanz","year":"2019","journal-title":"J Med Virol"},{"key":"2025120619121126000_73.6.328.13","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1002\/jmv.25479","article-title":"Impact of molecular point-of-care testing on clinical management and in-hospital costs of patients suspected of influenza or RSV infection: a modeling study","volume":"91","author":"Rahamat-Langendoen","year":"2019","journal-title":"J Med Virol"},{"key":"2025120619121126000_73.6.328.14","doi-asserted-by":"crossref","DOI":"10.1186\/s12879-017-2784-z","article-title":"Multiplex PCR point of care testing versus routine, laboratory-based testing in the treatment of adults with respiratory tract infections: a quasi-randomised study assessing impact on length of stay and antimicrobial use","volume":"17","author":"Andrews","year":"2017","journal-title":"BMC Infect Dis"},{"key":"2025120619121126000_73.6.328.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2015.07.008"},{"key":"2025120619121126000_73.6.328.16","doi-asserted-by":"crossref","first-page":"e00367","DOI":"10.1128\/JCM.00367-18","article-title":"Detection of Influenza A and B Viruses and Respiratory Syncytial Virus by Use of Clinical Laboratory Improvement Amendments of 1988 (CLIA)-Waived Point-of-Care Assays: a Paradigm Shift to Molecular Tests","volume":"56","author":"Azar","year":"2018","journal-title":"J Clin Microbiol"},{"key":"2025120619121126000_73.6.328.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2019.05.002"},{"key":"2025120619121126000_73.6.328.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2017.07.012"},{"key":"2025120619121126000_73.6.328.19","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01586-16"},{"key":"2025120619121126000_73.6.328.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2019.01.003"},{"key":"2025120619121126000_73.6.328.21","unstructured":"ID Now Influenza A & B 2 Product Insert 2018."},{"key":"2025120619121126000_73.6.328.22","unstructured":"ID Now RSV package insert 2018."},{"key":"2025120619121126000_73.6.328.23","unstructured":"cobas Influenza A\/B & RSV Package Insert 2018."},{"key":"2025120619121126000_73.6.328.24","unstructured":"Centers for Disease Control and Prevention . Influenza positive tests reported to CDC by U.S. clinical laboratories, 2018-2019 season, 2019. Available: https:\/\/www.cdc.gov\/flu\/weekly\/weeklyarchives2018-2019\/data\/whoAllregt_cl26.html"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2019-206242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:12:20Z","timestamp":1765077140000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2019-206242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,11]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,5,22]]},"published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1136\/jclinpath-2019-206242"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2019-206242","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/19008227","asserted-by":"object"}]},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,11]]}}}