{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:42:57Z","timestamp":1768808577714,"version":"3.49.0"},"reference-count":11,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2019,12,23]]},"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The purpose of this report is to describe a new instrument designed for the injection of therapeutic agents directly into the bone marrow cavity as well as to aspirate bone marrow specimens for the diagnostic purposes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The instrument consists of three parts: the needle, stilette and an adjustable guard. The overall length of the needle is 76\u2009mm and has uniform external diameter except for the distal penetrating segment, which is sharp but short and safe to use on the sternum. The proximal end of the needle is fitted with a plastic T-bar handle, which is ergonomically designed for firm grip and easy manoeuvrability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The instrument has been designed to obtain bone marrow aspirate specimens as well as to inject therapeutic agents into the posterior ilium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The rationale for the intramedullary injection of therapeutic agents for the treatment of patients with leukaemia, lymphoma and other haematological and non-haematological malignant disorders is described. In an emergency when intravenous therapy becomes difficult due to collapsed veins, this instrument may be used for direct intramarrow infusion of blood and blood products.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2019-206304","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T17:15:26Z","timestamp":1578590126000},"page":"552-556","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Intramarrow injection needle: a new technique to treat patients with haematological and non-haematological malignancies by directly injecting therapeutic agents into the bone marrow cavity"],"prefix":"10.1136","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2025-8610","authenticated-orcid":false,"given":"Anwarul","family":"Islam","sequence":"first","affiliation":[{"name":"Internal Medicine, Division of Hematology\/Oncology, Buffalo General Hospital, Buffalo, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,1,9]]},"reference":[{"key":"2025112110260927000_73.9.552.1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0306-9877(92)90149-7","article-title":"The origin and spread of human leukemia","volume":"39","author":"Islam","year":"1992","journal-title":"Med Hypotheses"},{"key":"2025112110260927000_73.9.552.2","unstructured":"Trafford Publishers . Manual of bone marrow examination. 2nd edn. Bloomington, Indiana, USA: Trafford Publishers, 2013."},{"key":"2025112110260927000_73.9.552.3","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/(SICI)1096-8652(199906)61:2<144::AID-AJH13>3.0.CO;2-6","article-title":"Spontaneous regression associated with apoptosis in a patient with acute-type adult T-cell leukemia","volume":"61","author":"Matsushita","year":"1999","journal-title":"Am J Hematol"},{"key":"2025112110260927000_73.9.552.4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1365-2257.1981.tb01328.x","article-title":"Spontaneous remission following bone marrow necrosis in chronic lymphocytic leukaemia","volume":"3","author":"Hughes","year":"1981","journal-title":"Clinical and Laboratory Hematology"},{"key":"2025112110260927000_73.9.552.5","first-page":"328","article-title":"Spontanremissionen bei Chronischer lymphoatischer leukamie","volume":"123","author":"Frick","year":"1993","journal-title":"Schweiz Med Wochenschr"},{"key":"2025112110260927000_73.9.552.6","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830310215"},{"key":"2025112110260927000_73.9.552.7","first-page":"2723","article-title":"Plasma pharmacokinetics of cyclophosphamide and its cytotoxic metabolites after intravenous versus oral administration in a randomized, crossover trial","volume":"47","author":"Struck","year":"1987","journal-title":"Cancer Res"},{"key":"2025112110260927000_73.9.552.8","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1200\/JCO.1988.6.12.1882","article-title":"Pharmacokinetics of subcutaneous methotrexate","volume":"6","author":"Balis","year":"1988","journal-title":"JCO"},{"key":"2025112110260927000_73.9.552.9","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1093\/jnci\/81.8.570","article-title":"Delivery of novel therapeutic agents in tumors: physiological barriers and strategies","volume":"81","author":"Jain","year":"1990","journal-title":"J Nat Canc Inst"},{"key":"2025112110260927000_73.9.552.10","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1002\/ccr3.429","article-title":"Induction treatment of acute myeloid leukemia in an elderly patient with intramarrow injection\/administration of cytarabine: first report of a case","volume":"3","author":"Islam","year":"2015","journal-title":"Clin Case Rep"},{"key":"2025112110260927000_73.9.552.11","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1002\/ccr3.1081","article-title":"Induction treatment of acute myeloid leukemia in an elderly patient with intramarrow injection\/administration of cytarabine. second case report","volume":"5","author":"Islam","year":"2017","journal-title":"Clin Case Rep"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2019-206304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:26:17Z","timestamp":1763749577000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2019-206304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,9]]},"references-count":11,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,8,19]]},"published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1136\/jclinpath-2019-206304"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2019-206304","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,9]]}}}