{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:09:48Z","timestamp":1769148588052,"version":"3.49.0"},"reference-count":27,"publisher":"BMJ","issue":"4","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81360355"],"award-info":[{"award-number":["81360355"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81660273"],"award-info":[{"award-number":["81660273"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Guangxi medical and health project","award":["Z20170007"],"award-info":[{"award-number":["Z20170007"]}]},{"name":"Guangxi Science Foundation","award":["2017GXNSFAA198055"],"award-info":[{"award-number":["2017GXNSFAA198055"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2020,2,17]]},"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The aim of this study is to investigate the expression profiles of cell cycle related proteins in nasal extranodal NK\/T cell lymphoma, nasal type (ENKTCL).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The expression profiles of cell cycle related proteins were assessed with a cell cycle antibody array and validated by immunohistochemistry. Correlations between the expression levels of proteins and clinical outcomes of patients with nasal ENKTCL were evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The expression of full length ataxia telangiectasia mutated (ATM) in nasal ENKTCL significantly decreased compared with that in nasal benign lymphoid proliferative disease (NBLPD), but the expression levels of p-ATM, CHK2 and RAD51 significantly increased in nasal ENKTCL compared with that in NBLPD. Kaplan-Meier analysis showed that the expression levels of p-ATM and CHK2 in nasal ENKTCL were inversely related to overall survival (p=0.011\u2009and p=0.025, respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Abnormalities in the ATM pathway may play a crucial role in the oncogenesis and chemoradiotherapy resistance of nasal ENKTCL.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jclinpath-2020-206476","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T17:15:43Z","timestamp":1585329343000},"page":"223-227","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Abnormal expression of p-ATM\/CHK2 in nasal extranodal NK\/T cell lymphoma, nasal type, is correlated with poor prognosis"],"prefix":"10.1136","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5829-189X","authenticated-orcid":false,"given":"Qiurong","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Pathology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiling","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zonghua","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Pathology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenwen","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pathology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongta","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianglan","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Pathology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,3,27]]},"reference":[{"key":"2025092501375959000_74.4.223.1","first-page":"81","article-title":"[The correction of mature T \/ NK cell lymphoma and EBV infection]","volume":"20","author":"Mo","year":"2012","journal-title":"Guangdong Medicine"},{"key":"2025092501375959000_74.4.223.2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1200\/JCO.2016.68.1619","article-title":"Treatments and outcomes of patients with extranodal natural killer\/T-cell lymphoma diagnosed between 2000 and 2013: a cooperative study in Japan","volume":"35","author":"Yamaguchi","year":"2017","journal-title":"J Clin Oncol"},{"key":"2025092501375959000_74.4.223.3","doi-asserted-by":"crossref","first-page":"6147","DOI":"10.2147\/OTT.S115294","article-title":"Chemotherapy combined with high-dose extended-field radiotherapy for stage I extranodal nasal-type natural killer\/T-cell lymphoma","volume":"9","author":"Luo","year":"2016","journal-title":"Onco Targets Ther"},{"key":"2025092501375959000_74.4.223.4","doi-asserted-by":"crossref","first-page":"20362","DOI":"10.18632\/oncotarget.13614","article-title":"A comparison of treatment modalities for nasal extranodal natural killer\/T-cell lymphoma in early stages: the efficacy of CHOP regimen based concurrent chemoradiotherapy","volume":"8","author":"Cao","year":"2017","journal-title":"Oncotarget"},{"key":"2025092501375959000_74.4.223.5","unstructured":"Mo X , Su Z , Zhou X , et al . The influence of inhibiting Skp2 expression on cell proliferation and apoptosis of NK\/T cell lymphoma cell. J Pract Med 2012."},{"key":"2025092501375959000_74.4.223.6","unstructured":"Swerdlow S , Campo E , Harris N , et al . Who classification of tumours of haematopoietic and lymphoid tissues. Revised 4th edition. Lyon: IARC, 2017."},{"key":"2025092501375959000_74.4.223.7","doi-asserted-by":"crossref","unstructured":"Mar\u00e9chal A , Zou L . Dna damage sensing by the ATM and ATR kinases. Cold Spring Harb Perspect Biol 2013;5. doi:doi:10.1101\/cshperspect.a012716. [Epub ahead of print: 01 Sep 2013].","DOI":"10.1101\/cshperspect.a012716"},{"key":"2025092501375959000_74.4.223.8","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2016.1158362"},{"key":"2025092501375959000_74.4.223.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2014.09.009"},{"key":"2025092501375959000_74.4.223.10","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.60"},{"key":"2025092501375959000_74.4.223.11","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8677"},{"key":"2025092501375959000_74.4.223.12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140819","article-title":"Association of germline CHEK2 gene variants with risk and prognosis of non-Hodgkin lymphoma","volume":"10","author":"Havranek","year":"2015","journal-title":"PLoS One"},{"key":"2025092501375959000_74.4.223.13","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1159\/000487724","article-title":"Chk2 promotes anoikis and is associated with the progression of papillary thyroid cancer","volume":"45","author":"Zhao","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"2025092501375959000_74.4.223.14","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3109\/10428190109064610","article-title":"Analysis of the Chk2 gene in lymphoid malignancies","volume":"42","author":"Tavor","year":"2001","journal-title":"Leuk Lymphoma"},{"key":"2025092501375959000_74.4.223.15","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.1093\/nar\/gkx126","article-title":"Rad51 interconnects between DNA replication, DNA repair and immunity","volume":"45","author":"Bhattacharya","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"2025092501375959000_74.4.223.16","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00430-017-0506-1","article-title":"Assessment of HTLV-1 proviral load, LAT, Bim, c-fos and Rad51 gene expression in adult T cell leukemia\/lymphoma","volume":"206","author":"Ramezani","year":"2017","journal-title":"Med Microbiol Immunol"},{"key":"2025092501375959000_74.4.223.17","article-title":"Rad51 expression is a useful predictive factor for the efficacy of neoadjuvant chemoradiotherapy in squamous cell carcinoma of the esophagus","volume":"21","author":"Nakanoko","year":"2014","journal-title":"Ann Surg Oncol"},{"key":"2025092501375959000_74.4.223.18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167868","article-title":"Overexpression of Rad51 predicts poor prognosis in colorectal cancer: our experience with 54 patients","volume":"12","author":"Li","year":"2017","journal-title":"PLoS One"},{"key":"2025092501375959000_74.4.223.19","doi-asserted-by":"crossref","first-page":"94247","DOI":"10.18632\/oncotarget.21686","article-title":"The relevance of prelamin A and Rad51 as molecular biomarkers in cervical cancer","volume":"8","author":"Leonardi","year":"2017","journal-title":"Oncotarget"},{"key":"2025092501375959000_74.4.223.20","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1007\/s12282-016-0750-z","article-title":"Simultaneous ATM\/BRCA1\/RAD51 expression variations associated with prognostic factors in Iranian sporadic breast cancer patients","volume":"24","author":"Hallajian","year":"2017","journal-title":"Breast Cancer"},{"key":"2025092501375959000_74.4.223.21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.lungcan.2017.01.009","article-title":"Prognostic and predictive value of loss of nuclear Rad51 immunoreactivity in resected non-small cell lung cancer patients","volume":"105","author":"Gachechiladze","year":"2017","journal-title":"Lung Cancer"},{"key":"2025092501375959000_74.4.223.22","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1080\/15384047.2017.1345391","article-title":"Simultaneous targeting of ATM and Mcl-1 increases cisplatin sensitivity of cisplatin-resistant non-small cell lung cancer","volume":"18","author":"Zhang","year":"2017","journal-title":"Cancer Biol Ther"},{"key":"2025092501375959000_74.4.223.23","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-0761"},{"key":"2025092501375959000_74.4.223.24","doi-asserted-by":"crossref","DOI":"10.1080\/23723556.2015.1012976","article-title":"Trial watch: targeting ATM-CHK2 and ATR-Chk1 pathways for anticancer therapy","volume":"2","author":"Manic","year":"2015","journal-title":"Mol Cell Oncol"},{"key":"2025092501375959000_74.4.223.25","doi-asserted-by":"crossref","first-page":"767","DOI":"10.3892\/or.2017.5724","article-title":"The homologous recombination protein Rad51 is a promising therapeutic target for cervical carcinoma","volume":"38","author":"Chen","year":"2017","journal-title":"Oncol Rep"},{"key":"2025092501375959000_74.4.223.26","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1080\/15384047.2015.1040951","article-title":"A peptide nucleic acid targeting nuclear Rad51 sensitizes multiple myeloma cells to melphalan treatment","volume":"16","author":"Alagpulinsa","year":"2015","journal-title":"Cancer Biol Ther"},{"key":"2025092501375959000_74.4.223.27","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.biopha.2017.09.078","article-title":"Curcumin sensitizes lymphoma cells to DNA damage agents through regulating Rad51-dependent homologous recombination","volume":"97","author":"Zhao","year":"2018","journal-title":"Biomed Pharmacother"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2020-206476","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:39:35Z","timestamp":1758789575000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2020-206476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,27]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,3,18]]},"published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1136\/jclinpath-2020-206476"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2020-206476","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,27]]}}}