{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T02:55:53Z","timestamp":1772765753273,"version":"3.50.1"},"reference-count":30,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2020,4,4]]},"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>L1 cell adhesion molecule (L1CAM) has been shown to be correlated with tumour progression, attributed to its possible association with epithelial-mesenchymal transition (EMT), characterised by the expression of vimentin and loss of e-cadherin. Herein, we investigate the associations between L1CAM and clinicopathological parameters, as well as the expression of vimentin and e-cadherin, in carcinomas restricted to the cervix.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The study was retrospective observational and included 45 squamous cell carcinomas (63.4%) and 26 adenocarcinomas (36.6%) submitted to primary surgical treatment. Patient age, FIGO (International Federation of Gynecology and Obstetrics) stage, tumour size and follow-up were obtained from the medical records. All the slides were revised to evaluate histological differentiation, lymphovascular space invasion, depth of infiltration, disease-free cervical wall thickness, pattern of invasion front, Silva pattern (for adenocarcinomas) and the percentage of tumour-infiltrating lymphocytes. Tissue microarrays were constructed for immunohistochemical staining for L1CAM, e-cadherin and vimentin.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Adenocarcinomas were associated with lower disease-free and overall survival. L1CAM and vimentin expressions were more frequent among adenocarcinomas, although loss of e-cadherin expression was more common among squamous carcinomas. L1CAM expression was associated with larger tumours, vimentin expression and lower disease-free survival. No association was observed between the expression of either L1CAM or vimentin and loss of e-cadherin. High levels of tumour-infiltrating lymphocytes were more frequent in squamous cell carcinoma, high-grade tumours, destructive pattern at front of invasion and loss of e-cadherin expression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our results confirm the prognostic role of L1CAM in cervical carcinomas, but suggest a role for mechanisms other than EMT.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jclinpath-2020-206500","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T17:15:35Z","timestamp":1588612535000},"page":"748-753","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["L1 cell adhesion molecule (L1CAM) in stage IB cervical cancer: distinct expression in squamous cell carcinomas and adenocarcinomas"],"prefix":"10.1136","volume":"73","author":[{"given":"Joao Paulo","family":"Mancusi de Carvalho","sequence":"first","affiliation":[{"name":"Gynecology, Universidade de Sao Paulo, Sao Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael C","family":"Salim","sequence":"additional","affiliation":[{"name":"Pathology, Universidade de Sao Paulo, Sao Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5838-3636","authenticated-orcid":false,"given":"Filomena Marino","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Pathology, Universidade de Sao Paulo, Sao Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luiza","family":"Nogueira Dias Genta","sequence":"additional","affiliation":[{"name":"Gynecology, Universidade de Sao Paulo, Sao Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund Chada","family":"Baracat","sequence":"additional","affiliation":[{"name":"Gynecology, Universidade de Sao Paulo, Sao Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus Paula","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Gynecology, Universidade de Sao Paulo, Sao Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,5,4]]},"reference":[{"key":"2025092506035122000_73.11.748.1","unstructured":"GLOBOCAN . Incidence, mortality and prevalence by cancer site, 2018. Available: http:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/76-brazil-fact-sheets.pdf"},{"key":"2025092506035122000_73.11.748.2","unstructured":"Estimativa . Incid\u00eancia de C\u00e2ncer no Brasil, 2018. Available: http:\/\/www.inca.gov.br"},{"key":"2025092506035122000_73.11.748.3","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000986"},{"key":"2025092506035122000_73.11.748.4","unstructured":"Kurman RJ CM , Herrington CS , Young RH . Who classification of tumours of female reproductive organs. 6th edn. IARC: Lyon, 2014."},{"key":"2025092506035122000_73.11.748.5","first-page":"5729","article-title":"Association of low expression of E-cadherin and \u03b2-catenin with the progression of early stage human squamous cervical cancer","volume":"17","author":"Jiang","year":"2019","journal-title":"Oncol Lett"},{"key":"2025092506035122000_73.11.748.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03787.x"},{"key":"2025092506035122000_73.11.748.7","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25797"},{"key":"2025092506035122000_73.11.748.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2019.04.010"},{"key":"2025092506035122000_73.11.748.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2011.08.025"},{"key":"2025092506035122000_73.11.748.10","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.160"},{"key":"2025092506035122000_73.11.748.11","doi-asserted-by":"crossref","first-page":"87568","DOI":"10.18632\/oncotarget.20976","article-title":"L1 cell adhesion molecule (L1CAM) is a strong predictor for locoregional recurrences in cervical cancer","volume":"8","author":"Schrevel","year":"2017","journal-title":"Oncotarget"},{"key":"2025092506035122000_73.11.748.12","first-page":"2792","article-title":"L1Cam promotes epithelial to mesenchymal transition and formation of cancer initiating cells in human endometrial cancer","volume":"15","author":"Chen","year":"2018","journal-title":"Exp Ther Med"},{"key":"2025092506035122000_73.11.748.13","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12749"},{"key":"2025092506035122000_73.11.748.14","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1999.5387"},{"key":"2025092506035122000_73.11.748.15","unstructured":"Cancer protocol templates. Available: https:\/\/www.cap.org\/protocols-and-guidelines\/cancer-reporting-tools\/cancer-protocol-templates"},{"key":"2025092506035122000_73.11.748.16","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu450"},{"key":"2025092506035122000_73.11.748.17","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e31829952c6"},{"key":"2025092506035122000_73.11.748.18","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020329"},{"key":"2025092506035122000_73.11.748.19","doi-asserted-by":"publisher","DOI":"10.4161\/cam.20832"},{"key":"2025092506035122000_73.11.748.20","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13128"},{"key":"2025092506035122000_73.11.748.21","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-019-0646-8"},{"key":"2025092506035122000_73.11.748.22","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2019.1667022"},{"key":"2025092506035122000_73.11.748.23","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-2106"},{"key":"2025092506035122000_73.11.748.24","doi-asserted-by":"publisher","DOI":"10.1002\/path.2673"},{"key":"2025092506035122000_73.11.748.25","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-10-127"},{"key":"2025092506035122000_73.11.748.26","doi-asserted-by":"publisher","DOI":"10.2217\/fon.15.332"},{"key":"2025092506035122000_73.11.748.27","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-018-2444-8"},{"key":"2025092506035122000_73.11.748.28","doi-asserted-by":"publisher","DOI":"10.1038\/nature21386"},{"key":"2025092506035122000_73.11.748.29","doi-asserted-by":"crossref","first-page":"13375","DOI":"10.18632\/oncotarget.14533","article-title":"Identification and characterization of HPV-independent cervical cancers","volume":"8","author":"Banister","year":"2017","journal-title":"Oncotarget"},{"key":"2025092506035122000_73.11.748.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2014.03.001"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2020-206500","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T13:04:07Z","timestamp":1758805447000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2020-206500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,4]]},"references-count":30,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,10,20]]},"published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1136\/jclinpath-2020-206500"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2020-206500","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,4]]}}}