{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:44:36Z","timestamp":1772163876209,"version":"3.50.1"},"reference-count":25,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/bmj.com\/coronavirus\/usage"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/010.000156\/2020"],"award-info":[{"award-number":["E-26\/010.000156\/2020"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/202.683\/2019"],"award-info":[{"award-number":["E-26\/202.683\/2019"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["309881\/2018-8"],"award-info":[{"award-number":["309881\/2018-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2020,12,15]]},"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to identify the symptoms associated with early stage SARS-CoV-2 (COVID-19) infections in healthcare professionals (HCPs) using both clinical and laboratory data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 1297 patients, admitted between 18 March and 8 April 2020, were stratified according to their risk of developing COVID-19 using their responses to a questionnaire designed to evaluate symptoms and risk conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Anosmia\/hyposmia (p&lt;0.0001), fever (p&lt;0.0001), body pain (p&lt;0.0001) and chills (p=0.001) were all independent predictors for COVID-19, with a 72% estimated probability for detecting COVID-19 in nasopharyngeal swab samples. Leucopenia, relative monocytosis, decreased eosinophil values, C reactive protein (CRP) and platelets were also shown to be significant independent predictors for COVID-19.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The significant clinical features for COVID-19 were identified as anosmia, fever, chills and body pain. Elevated CRP, leucocytes under 5400\u00d710\n                      <jats:sup>9<\/jats:sup>\n                      \/L and relative monocytosis (&gt;9%) were common among patients with a confirmed COVID-19 diagnosis. These variables may help, in the absence of reverse transcriptase PCR tests, to identify possible COVID-19 infections during pandemic outbreaks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>From 19 March to 8 April 2020, 1297 patients attended the Polyclinic Piquet Carneiro for COVID-19 detection. HCP data were analysed, and significant clinical features were anosmia, fever, chills and body pain. Elevated CRP, leucopenia and monocytosis were common in COVID-19.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2020-206797","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T14:44:58Z","timestamp":1612968298000},"page":"185-192","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical and laboratory characteristics in outpatient diagnosis of COVID-19 in healthcare professionals in Rio de Janeiro, Brazil"],"prefix":"10.1136","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1499-1821","authenticated-orcid":false,"given":"Luis Cristovao","family":"Porto","sequence":"first","affiliation":[{"name":"Histocompatibility and Cryopreservation Laboratory, Institute of Biology Roberto Alcantara Gomes, UERJ, Rio de Janeiro, Brazil"},{"name":"Clinical Pathology Service, Polyclinic Piquet Carneiro, UERJ, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia H","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Tisiology, Faculty of Medical Sciences and Service of Pulmonology, Polyclinic Piquet Carneiro, UERJ, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra S","family":"Nunes","sequence":"additional","affiliation":[{"name":"Medical Surgical Nursing Department, Nursing Faculty, Polyclinic Piquet Carneiro, UERJ, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Bouzas","sequence":"additional","affiliation":[{"name":"Health Research Support Facility Center (CAPCS), Polyclinic Piquet Carneiro, UERJ, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiago F","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Infectology Service, Polyclinic Piquet Carneiro, UERJ, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinicius M","family":"Porto","sequence":"additional","affiliation":[{"name":"Clinical Pathology Service, Polyclinic Piquet Carneiro, UERJ, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle A","family":"Secco","sequence":"additional","affiliation":[{"name":"Histocompatibility and Cryopreservation Laboratory, Institute of Biology Roberto Alcantara Gomes, UERJ, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Vilas Boas","sequence":"additional","affiliation":[{"name":"Clinical Pathology Service, Polyclinic Piquet Carneiro, UERJ, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anamelia Costa","family":"Faria","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Tisiology, Faculty of Medical Sciences and Service of Pulmonology, Polyclinic Piquet Carneiro, UERJ, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rogerio","family":"Rufino","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Tisiology, Faculty of Medical Sciences and Service of Pulmonology, Polyclinic Piquet Carneiro, UERJ, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,2,10]]},"reference":[{"key":"2025112109433859000_75.3.185.1","unstructured":"University JH . 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