{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T01:36:09Z","timestamp":1784079369265,"version":"3.55.0"},"reference-count":18,"publisher":"BMJ","issue":"8","funder":[{"DOI":"10.13039\/100005615","name":"Beth Israel Deaconess Medical Center","doi-asserted-by":"publisher","award":["Funding was provided by RSG\u2019s institutional star"],"award-info":[{"award-number":["Funding was provided by RSG\u2019s institutional star"]}],"id":[{"id":"10.13039\/100005615","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2020,8,17]]},"published-print":{"date-parts":[[2021,8]]},"abstract":"\n Aims<\/jats:title>\n \n Evaluate the rate and significance of\n Helicobacter pylori<\/jats:italic>\n (\n H. pylori<\/jats:italic>\n ) involving duodenal foveolar metaplasia of chronic peptic duodenitis (CPD).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We identified 100 biopsy cases of CPD with synchronous stomach biopsies. All 200 were reviewed for histological changes (eg, chronic gastritis, acute inflammation) and underwent immunohistochemical staining for\n H. pylori<\/jats:italic>\n . Results were correlated with patient age, sex, endoscopy indication and findings on stomach biopsy.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Cases included 49 men and 51 women, with a median age of 56 years. Reflux or dysphagia was the most common symptom. Chronic gastritis was present in 46 stomach biopsies, with 54 within normal limits. Twelve stomach biopsies showed\n H. pylori<\/jats:italic>\n , all of which showed gastritis. Two duodenal biopsies (2%) demonstrated\n H. pylori<\/jats:italic>\n organisms on immunohistochemistry, both from patients with\n H. pylori<\/jats:italic>\n gastritis.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Routine examination of CPD samples for\n H. pylori<\/jats:italic>\n appears unnecessary if a stomach biopsy is available for review.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/jclinpath-2020-206844","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T17:22:08Z","timestamp":1600190528000},"page":"537-539","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Helicobacter pylori<\/i>\n colonisation of duodenal foveolar metaplasia requires concurrent gastric infection"],"prefix":"10.1136","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1231-4117","authenticated-orcid":false,"given":"Adam L","family":"Booth","sequence":"first","affiliation":[{"name":"Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul S","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,9,15]]},"reference":[{"key":"2025120518031353000_74.8.537.1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000097"},{"key":"2025120518031353000_74.8.537.2","article-title":"Diagnosis of Helicobacter pylori by invasive test: histology","volume":"3","author":"Lee","year":"2015","journal-title":"Ann Transl Med"},{"key":"2025120518031353000_74.8.537.3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bj.2015.06.002","article-title":"Helicobacter pylori infection: an overview of bacterial virulence factors and pathogenesis","volume":"39","author":"Kao","year":"2016","journal-title":"Biomed J"},{"key":"2025120518031353000_74.8.537.4","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184400","article-title":"The Interaction of Helicobacter pylori with TFF1 and Its Role in Mediating the Tropism of the Bacteria Within the Stomach","volume":"20","author":"Clyne","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2025120518031353000_74.8.537.5","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/his.13632","article-title":"The outlet patch: gastric heterotopia of the colorectum and anus","volume":"73","author":"Mannan","year":"2018","journal-title":"Histopathology"},{"key":"2025120518031353000_74.8.537.6","doi-asserted-by":"crossref","first-page":"222","DOI":"10.5858\/1999-123-0222-SPGHOR","article-title":"Sessile polypoid gastric heterotopia of rectum: a report of 2 cases and review of the literature","volume":"123","author":"Srinivasan","year":"1999","journal-title":"Arch Pathol Lab Med"},{"key":"2025120518031353000_74.8.537.7","unstructured":"Odze RD , Goldblum JR . Odze and Goldblum surgical pathology of the Gi tract, liver, biliary tract, and pancreas. Third edn. Philadelphia, PA: Saunders\/Elsevier;, 2015: 1\u20131612."},{"key":"2025120518031353000_74.8.537.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2010.04.010"},{"key":"2025120518031353000_74.8.537.9","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.40.8.841"},{"key":"2025120518031353000_74.8.537.10","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.031260"},{"key":"2025120518031353000_74.8.537.11","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPD8FFBJ5LSLTE"},{"key":"2025120518031353000_74.8.537.12","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800404"},{"key":"2025120518031353000_74.8.537.13","unstructured":"Arnold CA , DMa L-H , Ea M . Atlas of gastrointestinal pathology : a pattern based approach to non-neoplastic biopsies, 2014."},{"key":"2025120518031353000_74.8.537.14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1155\/DTE.6.17","article-title":"Incidence of Gastric Metaplasia and Helicobacter pylori Infection in Duodenal Bulb - With Specific Reference to Patients With Duodenal Ulcers","volume":"6","author":"Kawaguchi","year":"1999","journal-title":"Diagn Ther Endosc"},{"key":"2025120518031353000_74.8.537.15","first-page":"176","article-title":"Effect of Helicobacter pylori eradication on bulbitis and duodenal gastric metaplasia","volume":"51","author":"Suriani","year":"2004","journal-title":"Hepatogastroenterology"},{"key":"2025120518031353000_74.8.537.16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2001.02482.x"},{"key":"2025120518031353000_74.8.537.17","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70121-6"},{"key":"2025120518031353000_74.8.537.18","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8566592"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2020-206844","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T02:03:18Z","timestamp":1764986598000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2020-206844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,15]]},"references-count":18,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,7,19]]},"published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1136\/jclinpath-2020-206844"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2020-206844","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,15]]}}}