{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:26:40Z","timestamp":1790713600037,"version":"4.1.0"},"reference-count":27,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2020,6,27]]},"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>\n                    The\n                    <jats:italic>GLIS 1\u20133<\/jats:italic>\n                    genes belong to a family of transcription factors, the Kr\u00fcppel-like zinc finger proteins. The GLIS proteins function primarily as activators of transcription (GLIS 1 and 3), while GLIS 2 functions as a repressor. Collectively, the GLIS proteins are involved in a variety of diseases in several organs ranging from Alzheimer\u2019s disease, facial dysmorphism, neonatal diabetes mellitus, breast and colon cancers and leukaemia. In particular, loss-of-function mutations in\n                    <jats:italic>GLIS2<\/jats:italic>\n                    are responsible for an autosomal recessive cystic kidney disease called nephronophthisis, which is characterised by tubular atrophy, interstitial fibrosis and corticomedullary cysts.\n                  <\/jats:p>\n                  <jats:p>\n                    Of diagnostic value in current practice are the presence of\n                    <jats:italic>GLIS 3<\/jats:italic>\n                    and\n                    <jats:italic>1<\/jats:italic>\n                    fusions with\n                    <jats:italic>PAX8<\/jats:italic>\n                    in almost 100% of hyalinising trabecular tumours of the thyroid gland. This enables its separation from papillary thyroid cancer.\n                  <\/jats:p>","DOI":"10.1136\/jclinpath-2020-206859","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T17:25:34Z","timestamp":1595438734000},"page":"527-530","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Gene of the month:\n                    <i>GLIS1-3<\/i>"],"prefix":"10.1136","volume":"73","author":[{"given":"Karen","family":"Pinto","sequence":"first","affiliation":[{"name":"Pathology, Kuwait Cancer Control Center, Shuwaikh, Al Asimah, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2124-515X","authenticated-orcid":false,"given":"Runjan","family":"Chetty","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Brighton and Sussex University Hospitals NHS Trust, Brighton, 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