{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:10:22Z","timestamp":1765699822445,"version":"3.48.0"},"reference-count":20,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2020,9,27]]},"published-print":{"date-parts":[[2021,10]]},"abstract":"\n Aims<\/jats:title>\n The presence of detectable faecal haemoglobin (f-Hb) has been shown to be associated with all-cause mortality and with death from a number of chronic diseases not known to cause gastrointestinal blood loss. This effect is independent of taking medicines that increase the risk of bleeding. To further investigate the association of f-Hb with chronic disease, the relationship between f-Hb and prescription of medicines for a variety of conditions was studied.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n All subjects (134 192) who participated in guaiac faecal occult blood test (gFOBT) screening in Tayside, Scotland, between March 2000 and March 2016, were studied in a cross-sectional manner by linking their gFOBT result (abnormal or normal) with prescribing data at the time of the test.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The screening participants with an abnormal gFOBT result were more likely to have been being prescribed medicines for heart disease, hypertension, diabetes and depression than those with a normal test result. This association persisted after adjustment for sex, age and deprivation (OR 1.35 (95%CI 1.23 to 1.48), 1.39 (1.27 to 1.52), 1.35 (1.15 to 1.58), 1.36 (1.16 to 1.59), all p<0.0001, for the four medicine categories, respectively).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The results of this study confer further substantial weight to the concept that detectable f-Hb is associated with a range of common chronic conditions that have a systemic inflammatory component; we speculate that f-Hb might have potential in identifying individuals who are high risk of developing chronic conditions or are at an early stage of disease.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/jclinpath-2020-206986","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T17:20:34Z","timestamp":1602609634000},"page":"664-667","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Association between faecal occult bleeding and medicines prescribed for chronic disease: a data linkage study"],"prefix":"10.1136","volume":"74","author":[{"given":"Gillian","family":"Libby","sequence":"first","affiliation":[{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds Faculty of Medicine and Health, Leeds, West Yorkshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen N","family":"Barnett","sequence":"additional","affiliation":[{"name":"Division of Public Health and Genomics, University of Dundee School of Medicine, Dundee, Scotland, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1333-7994","authenticated-orcid":false,"given":"Callum G","family":"Fraser","sequence":"additional","affiliation":[{"name":"Centre for Research into Cancer Prevention & Screening, University of Dundee School of Medicine, Dundee, Scotland, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4248-6785","authenticated-orcid":false,"given":"Robert J C","family":"Steele","sequence":"additional","affiliation":[{"name":"Centre for Research into Cancer Prevention & Screening, University of Dundee School of Medicine, Dundee, Scotland, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,10,13]]},"reference":[{"key":"2025121400064150000_74.10.664.1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-316483"},{"key":"2025121400064150000_74.10.664.2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.162883"},{"key":"2025121400064150000_74.10.664.3","doi-asserted-by":"publisher","DOI":"10.1258\/jms.2011.011098"},{"key":"2025121400064150000_74.10.664.4","unstructured":"Scottish index of multiple deprivation 2016: introductory booklet. Available: https:\/\/www.gov.scot\/publications\/scottish-index-multiple-deprivation-2016\/ [Accessed 18 Jun 2020]."},{"key":"2025121400064150000_74.10.664.5","doi-asserted-by":"publisher","DOI":"10.1258\/jms.2010.009120"},{"key":"2025121400064150000_74.10.664.6","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-003740"},{"key":"2025121400064150000_74.10.664.7","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-032633"},{"key":"2025121400064150000_74.10.664.8","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-021153"},{"key":"2025121400064150000_74.10.664.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2014.04.006"},{"key":"2025121400064150000_74.10.664.10","doi-asserted-by":"crossref","DOI":"10.1515\/cclm-2020-0268","article-title":"Faecal haemoglobin distributions by sex, age, deprivation and geographical region: consequences for colorectal cancer screening strategies","author":"Clark","year":"2020","journal-title":"Clin Chem Lab Med"},{"key":"2025121400064150000_74.10.664.11","unstructured":"Scottish heart disease statistics. Available: https:\/\/beta.isdscotland.org\/find-publications-and-data\/conditions-and-diseases\/heart-disease-and-blood-vessels\/heart-disease-statistics\/ [Accessed 18 Jun 2020]."},{"key":"2025121400064150000_74.10.664.12","unstructured":"Health matters: combating high blood pressure. Available: https:\/\/www.gov.uk\/government\/publications\/health-matters-combating-high-blood-pressure\/health-matters-combating-high-blood-pressure [Accessed 18 Jun 2020]."},{"key":"2025121400064150000_74.10.664.13","unstructured":"Health matters: preventing type 2 diabetes. Available: https:\/\/www.gov.uk\/government\/publications\/health-matters-preventing-type-2-diabetes\/health-matters-preventing-type-2-diabetes [Accessed 18 Jun 2020]."},{"key":"2025121400064150000_74.10.664.14","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2313-3"},{"key":"2025121400064150000_74.10.664.15","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp12X653633"},{"key":"2025121400064150000_74.10.664.16","unstructured":"Health conditions. Available: https:\/\/www.isdscotland.org\/Health-Topics\/General-Practice\/GP-Consultations\/Health-Conditions\/Depression\/ [Accessed 18 Jun 2020]."},{"key":"2025121400064150000_74.10.664.17","unstructured":"NHS health check. Available: https:\/\/www.nhs.uk\/conditions\/nhs-health-check\/ [Accessed 20 Sep 2020]."},{"key":"2025121400064150000_74.10.664.18","doi-asserted-by":"publisher","DOI":"10.1177\/0969141313497197"},{"key":"2025121400064150000_74.10.664.19","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310691"},{"key":"2025121400064150000_74.10.664.20","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2018-205047"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2020-206986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:06:50Z","timestamp":1765699610000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2020-206986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,13]]},"references-count":20,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,9,20]]},"published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1136\/jclinpath-2020-206986"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2020-206986","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[2020,10,13]]}}}