{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:27:14Z","timestamp":1788438434566,"version":"build-2803163510"},"reference-count":23,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2021,3,23]]},"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Diffuse large B-cell lymphoma (DLBCL) is characterised by marked clinical and biological heterogeneity, attributable to the tumour cells and their microenvironment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this study, we investigated circulating subsets of blood lymphocytes and monocytes and their relationship with T cells in the tumour microenvironment (TME) in chemoresistant and chemosensitive patients with DLBCL.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The study showed that (1) absolute lymphocyte count (ALC) and CD3+ and CD4+ cells were reduced in chemoresistant patients compared with chemosensitive patients; (2) lymphocyte:monocyte ratio (LMR) showed a positive correlation with peripheral blood CD3+ and CD4+ cells; (3) ALC, LMR, peripheral blood CD3+ and CD4+ cells showed a positive correlation with T cells in the TME.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Overall, these data suggest that DLBCL with high TME T cells display a pre-existing antitumour immune response. In the rituximab-containing regimen, TME T cells are stimulated further to participate in the immune response against lymphoma cells. In contrast, DLBCL lymphomas with low T-cell infiltration reflect the absence of a pre-existing antitumour immunity and have a lower likelihood of obtaining an optimal response to therapy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jclinpath-2020-207048","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T13:25:45Z","timestamp":1621430745000},"page":"493-497","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Correlation between circulating blood and microenvironment T lymphocytes in diffuse large B-cell lymphomas"],"prefix":"10.1136","volume":"75","author":[{"given":"Filomena Emanuela","family":"Laddaga","sequence":"first","affiliation":[{"name":"Clinical Pathology Unit, AOU Consorziale Policlinico, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Ingravallo","sequence":"additional","affiliation":[{"name":"Pathology Unit, AOU Consorziale Policlinico, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Mestice","sequence":"additional","affiliation":[{"name":"Hematology and Stem Cell Transplantation Unit, AOU Consorziale Policlinico, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Tamma","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommasina","family":"Perrone","sequence":"additional","affiliation":[{"name":"Hematology and Stem Cell Transplantation Unit, AOU Consorziale Policlinico, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Maiorano","sequence":"additional","affiliation":[{"name":"Pathology Unit, AOU Consorziale Policlinico, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Ribatti","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgina","family":"Specchia","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7817-1665","authenticated-orcid":false,"given":"Francesco","family":"Gaudio","sequence":"additional","affiliation":[{"name":"Hematology and Stem Cell Transplantation Unit, AOU Consorziale Policlinico, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,5,19]]},"reference":[{"key":"2025092509531345000_75.7.493.1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-293050"},{"key":"2025092509531345000_75.7.493.2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2011.04.001"},{"key":"2025092509531345000_75.7.493.3","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2019.1678154"},{"key":"2025092509531345000_75.7.493.4","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00277-017-3212-6","article-title":"Computer-driven quantitative image analysis in the assessment of tumor cell and T cell features in diffuse large B cell lymphomas","volume":"97","author":"Gaudio","year":"2018","journal-title":"Ann Hematol"},{"key":"2025092509531345000_75.7.493.5","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3774"},{"key":"2025092509531345000_75.7.493.6","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2703"},{"key":"2025092509531345000_75.7.493.7","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.112"},{"key":"2025092509531345000_75.7.493.8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041658"},{"key":"2025092509531345000_75.7.493.9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02649.x"},{"key":"2025092509531345000_75.7.493.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2014.09.007"},{"key":"2025092509531345000_75.7.493.11","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-015-0354-5"},{"key":"2025092509531345000_75.7.493.12","doi-asserted-by":"publisher","DOI":"10.1159\/000324206"},{"key":"2025092509531345000_75.7.493.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.11.006"},{"key":"2025092509531345000_75.7.493.14","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2947"},{"key":"2025092509531345000_75.7.493.15","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23398"},{"key":"2025092509531345000_75.7.493.16","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00277-018-3534-z","article-title":"Novel risk stratification of de novo diffuse large B cell lymphoma based on tumour-infiltrating T lymphocytes evaluated by flow cytometry","volume":"98","author":"Chen","year":"2019","journal-title":"Ann Hematol"},{"key":"2025092509531345000_75.7.493.17","first-page":"361","article-title":"Tumor-infiltrating T-lymphocytes in B-cell diffuse large cell lymphoma related to disease course","volume":"3","author":"Lippman","year":"1990","journal-title":"Mod Pathol"},{"key":"2025092509531345000_75.7.493.18","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23398"},{"key":"2025092509531345000_75.7.493.19","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.200105"},{"key":"2025092509531345000_75.7.493.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2015.10.012"},{"key":"2025092509531345000_75.7.493.21","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-10-248609"},{"key":"2025092509531345000_75.7.493.22","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-185280"},{"key":"2025092509531345000_75.7.493.23","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/hon.2439_27","article-title":"Microenvironment expression in diffuse large B-cell lymphomas","volume":"35","author":"Gaudio","year":"2017","journal-title":"Hematol Oncol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2020-207048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:53:17Z","timestamp":1758819197000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2020-207048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,19]]},"references-count":23,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,6,17]]},"published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1136\/jclinpath-2020-207048"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2020-207048","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,19]]}}}