{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T06:52:39Z","timestamp":1767423159710,"version":"3.44.0"},"reference-count":26,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2020,11,9]]},"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To evaluate the influence of an algorithm designed to incorporate reflex testing according to haemogram results for analytical tests ordered to investigate anaemia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In 2020, a new request for \u2018initial study of anaemia\u2019 was created in three primary care pilot centres for suspected anaemia or new anaemias. A haemogram was ordered and the remainder of the tests were created in a reflex manner according to an algorithm integrated in the laboratory information system that also generates a comment that is completed and validated by a haematologist. The demand for tests was evaluated over three time periods.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 396 requests, anaemia was detected in 80 (20.2%), with 26 microcytic anaemias (6.57%), 20 iron deficiency anaemias, 41 (10.3%) normocytic anaemias and 13 macrocytic anaemias (3.28%); 4 with folate deficiency; and 1 haemolytic anaemia. No haematological diseases were detected. Twenty-four (6.06%) cases exhibited microcytosis\/hypochromia without anaemia, 12 of which exhibited iron deficiency. Four young women exhibiting within-limit haemoglobin levels had iron deficiency. There were 56 (14.1%) cases of macrocytosis without anaemia.<\/jats:p>\n                  <jats:p>With the new profile of \u2018initial study of anaemia\u2019, the demand for tests was reduced and was significantly lower than in the remainder of primary centres for iron, transferrin, ferritin, vitamin B<jats:sub>12<\/jats:sub> and folate.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>A new profile of \u2018initial study of anaemia\u2019 in the request form with algorithms integrated in the laboratory information system enabled submission of orders and decreased the demand for unnecessary iron, transferrin, ferritin, vitamin B<jats:sub>12<\/jats:sub> and folate tests.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jclinpath-2020-207130","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T18:32:15Z","timestamp":1606242735000},"page":"94-98","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Initial study of anaemia profile for primary care centres with automated laboratory algorithms reduces the demand for ferritin, iron, transferrin, vitamin B<sub>12<\/sub> and folate tests"],"prefix":"10.1136","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1809-6587","authenticated-orcid":false,"given":"J R","family":"Furundarena","sequence":"first","affiliation":[{"name":"Hematology Laboratory, Donostia University Hospital Aranzazu Building, San Sebastian, Pa\u00eds Vasco, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alasne","family":"Uranga","sequence":"additional","affiliation":[{"name":"Hematology Laboratory, Donostia University Hospital Aranzazu Building, San Sebastian, Pa\u00eds Vasco, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Hematology Laboratory, Donostia University Hospital Aranzazu Building, San Sebastian, Pa\u00eds Vasco, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Hematology Laboratory, Donostia University Hospital Aranzazu Building, San Sebastian, Pa\u00eds Vasco, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June","family":"Iriondo","sequence":"additional","affiliation":[{"name":"Hematology Laboratory, Donostia University Hospital Aranzazu Building, San Sebastian, Pa\u00eds Vasco, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laida","family":"Ondarra","sequence":"additional","affiliation":[{"name":"Hematology Laboratory, Donostia 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