{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:35:20Z","timestamp":1787819720172,"version":"build-2784847793"},"reference-count":19,"publisher":"BMJ","issue":"6","funder":[{"name":"NRC-LPCC\/CIMAGO","award":["Genomic Characterization of Monoclonal Gammopathie"],"award-info":[{"award-number":["Genomic Characterization of Monoclonal Gammopathie"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2021,2,18]]},"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>Multiple myeloma (MM) genomic complexity reflects in the variable patients\u2019 clinical presentation. Genome-wide studies seem to be a reasonable alternative to identify critical genomic lesions. In the current study, we have performed the genomic characterisation of a Portuguese cohort of patients with MM by array comparative genomic hybridisation. Overall, the most frequently detected alterations were 13q deletions, gains of 1q, 19p, 15q, 5p and 7p and trisomy 9. Even though some identified genomic alterations were previously associated with a prognostic value, other abnormalities remain with unknown, but putative significance for patients\u2019 clinical practice. These genomic alterations should be further assessed as possible biomarkers.<\/jats:p>","DOI":"10.1136\/jclinpath-2020-207204","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T13:20:30Z","timestamp":1614691230000},"page":"422-425","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Genomic characterisation of multiple myeloma: study of a Portuguese cohort"],"prefix":"10.1136","volume":"75","author":[{"given":"Alexandra","family":"Couto Oliveira","sequence":"first","affiliation":[{"name":"University of Coimbra, Cytogenetics and Genomics Laboratory, Faculty of Medicine, Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilda Patr\u00edcia","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"University of Coimbra, Cytogenetics and Genomics Laboratory, Faculty of Medicine, Coimbra, Portugal"},{"name":"University of Coimbra, Coimbra Institute 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