{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T18:44:06Z","timestamp":1764873846229,"version":"3.44.0"},"reference-count":20,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2021,4,22]]},"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Clear cells formed due to depositions of glycogen or lipids in the cytoplasm commonly occur in various tissues. Adipophilin (ADP), a lipid regulatory protein, is closely related to lipid droplets. This study aims to examine adipophilin expression in clear cells of various skin lesions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>ADP expression was examined using immunohistochemistry in 108 sections from 15 skin lesion types with clear cell histology, namely, sebaceoma (n=16), sebaceous adenoma (n=3), sebaceous carcinoma (n=12), xanthomata cutis (n=10), xanthogranuloma (n=8), Paget\u2019s disease (n=10), Bowen disease (n=10), hidradenoma (n=9), atypical lipoma (n=5), superficial lipomatous nevus (n=5), metastatic renal cell carcinoma (n=5), squamous cell carcinoma (n=4), seborrheic keratosis (n=4), dermatofibroma (n=4) and clear cell sarcoma (n=3).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>ADP was not expressed in Bowen disease, hidradenoma or seborrheic keratosis. Four expression patterns, foamy, reticular, granular and punctate, were summarised based on their expression in clear cells. Different expression patterns were related to tissue origin and differentiation degree. Foamy expression was commonly observed in lesions with mature sebaceous glands and xanthomas; reticular expression in adipocytes; granular expression in xanthoma, xanthogranuloma and metastatic renal carcinoma and punctate expression in sebaceoma, sebaceous carcinoma, Paget\u2019s disease, squamous cell carcinoma and clear cell sarcoma. Furthermore, stronger staining with focal vesicular labelling was noted in sebaceoma than in sebaceous carcinoma. Characteristic labelling was noted, including the circular distribution in Touton giant cells of xanthogranulomas and focal distribution in the clear cells along the edge of necrotic tissue in clear cell sarcoma.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>ADP is useful in identifying intracytoplasmic lipids and can be used to diagnose skin lesions with clear cell histology, especially in some lesions with characteristic labelling.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jclinpath-2021-207443","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T15:40:34Z","timestamp":1620229234000},"page":"627-631","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Adipophilin expression in skin lesions with clear cell histology"],"prefix":"10.1136","volume":"75","author":[{"given":"Feng-Zeng","family":"Li","sequence":"first","affiliation":[{"name":"Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Ye","sequence":"additional","affiliation":[{"name":"Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Wei","family":"Ran","sequence":"additional","affiliation":[{"name":"Dermatology, Beijing Chaoyang Hospital Jingxi Branch, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1098-7542","authenticated-orcid":false,"given":"Sheng","family":"Fang","sequence":"additional","affiliation":[{"name":"Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 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carcinoma and its distinction from its mimics: adipophilin and factor XIIIa to the rescue?","volume":"45","author":"Tetzlaff","year":"2018","journal-title":"J Cutan Pathol"},{"key":"2025092510201870000_75.9.627.11","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-019-0358-y"},{"key":"2025092510201870000_75.9.627.12","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.pan.2019.03.001","article-title":"Adipophilin expression is an indicator of poor prognosis in patients with pancreatic ductal adenocarcinoma: an immunohistochemical analysis","volume":"19","author":"Hashimoto","year":"2019","journal-title":"Pancreatology"},{"key":"2025092510201870000_75.9.627.13","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00428-020-02777-w","article-title":"The clinicopathological significance of the adipophilin and fatty acid synthase expression in salivary duct carcinoma","volume":"477","author":"Hirai","year":"2020","journal-title":"Virchows 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