{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T01:26:36Z","timestamp":1768094796486,"version":"3.49.0"},"reference-count":17,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2021,3,15]]},"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cribriform comedo-type adenocarcinoma was a colon cancer subtype recognised in the previous WHO classification of tumours that is no longer included in the recent edition. Previous reports have described colon cancers with cribriform growth as having worse overall survival and being associated with microsatellite stability. We sought to validate whether cribriform carcinoma (CC) is a distinct morphological subtype with clinical relevance in the context of modern colon cancer diagnosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Consecutive cases of non-neoadjuvantly treated colon cancer resections were identified (n=177) and reviewed to evaluate for CC and other histopathological and clinical features. CC was defined as solid nests of cancer with round, \u2018punched out\u2019 spaces and intraluminal bridges, reminiscent of ductal carcinoma in situ of the breast.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>CC was present in 18.6% of the consecutive case cohort. Compared with all other cases, CC was associated with positive lymph nodes, increased depth of invasion, extramural venous involvement (EMVI), and microsatellite stability, and was less likely to have tumour infiltrating lymphocytes (p&lt;0.05). In contrast to previous reports, we did not find significantly worse overall, disease-specific or recurrence-free survival for CC. Morphological features mimicking CC occurred in 33.3% of all other colon cancer cases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Identifying CC may be useful due to its association with worse stage at presentation and EMVI, but given that cribriform-like appearance may be found in many colon cancer cases and that we did not find a survival difference for CC, CC may not necessitate its own subtype classification.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jclinpath-2021-207485","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T13:25:11Z","timestamp":1617024311000},"page":"483-487","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Cribriform colon cancer: a morphological growth pattern associated with extramural venous invasion, nodal metastases and microsatellite stability"],"prefix":"10.1136","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2126-9987","authenticated-orcid":false,"given":"Alexander S","family":"Taylor","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayun M","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Panarelli","sequence":"additional","affiliation":[{"name":"Department of Pathology, Montefiore Medical Center, Bronx, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Purva","family":"Gopal","sequence":"additional","affiliation":[{"name":"Department of Pathology, UT Southwestern, Dallas, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suntrea","family":"Hammer","sequence":"additional","affiliation":[{"name":"Department of Pathology, UT Southwestern, Dallas, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pathology, UT Southwestern, Dallas, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Appelman","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Westerhoff","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,3,29]]},"reference":[{"key":"2025092504121166000_75.7.483.1","unstructured":"World Health Organization . Who classification of tumours of the digestive system. 4 edn. Lyon: International Agency for Research on Cancer, 2010."},{"key":"2025092504121166000_75.7.483.2","unstructured":"World Health Organization . Digestive system tumours. 5 edn. Lyon: World Health Organization, 2019."},{"key":"2025092504121166000_75.7.483.3","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000155144.53047.7d"},{"key":"2025092504121166000_75.7.483.4","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2015-203203"},{"key":"2025092504121166000_75.7.483.5","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800030"},{"key":"2025092504121166000_75.7.483.6","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4132\/jptm.2015.02.05","article-title":"Pathologic factors associated with prognosis after adjuvant chemotherapy in stage II\/III microsatellite-unstable colorectal cancers","volume":"49","author":"Kim","year":"2015","journal-title":"J Pathol Transl Med"},{"key":"2025092504121166000_75.7.483.7","doi-asserted-by":"publisher","DOI":"10.1177\/1066896914542125"},{"key":"2025092504121166000_75.7.483.8","unstructured":"American Cancer Society . American Joint Committee on Cancer. In: Mahul B , Amin MD , Stephen B , eds. AJCC cancer staging manual. 8 edn. Chicago IL: American Joint Committee on Cancer, Springer, 2017."},{"key":"2025092504121166000_75.7.483.9","unstructured":"Burgart LJ , Kakar S , Shi C . Protocol for the examination of resection specimens from patients with primary carcinoma of the colon and rectum, 2020. Available: https:\/\/documents.cap.org\/protocols\/cp-gilower-colonrectum-resection-20-4100.pdf [Accessed 29 May 2020]."},{"key":"2025092504121166000_75.7.483.10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/ajcp\/aqy032","article-title":"Clinical significance of complex glandular patterns in lung adenocarcinoma: clinicopathologic and molecular study in a large series of cases","volume":"150","author":"Kuang","year":"2018","journal-title":"Am J Clin Pathol"},{"key":"2025092504121166000_75.7.483.11","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/modpathol.2016.49","article-title":"Disease-Specific survival of patients with invasive cribriform and intraductal prostate cancer at diagnostic biopsy","volume":"29","author":"Kweldam","year":"2016","journal-title":"Mod Pathol"},{"key":"2025092504121166000_75.7.483.12","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26310"},{"key":"2025092504121166000_75.7.483.13","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/jso.25367","article-title":"Impact of intramural and extramural vascular invasion on stage II-III colon cancer outcomes","volume":"119","author":"Leijssen","year":"2019","journal-title":"J Surg Oncol"},{"key":"2025092504121166000_75.7.483.14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/1598670","article-title":"Extramural venous invasion as prognostic factor of recurrence in stage 1 and 2 colon cancer","volume":"2017","author":"van Eeghen","year":"2017","journal-title":"Gastroenterol Res Pract"},{"key":"2025092504121166000_75.7.483.15","unstructured":"Loughrey M , Quirke P , Shepherd N . 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