{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T03:22:41Z","timestamp":1765596161810,"version":"3.48.0"},"reference-count":19,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2021,4,28]]},"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p>\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    is the most frequent cause of chronic active gastritis (CAG), namely the first step for gastric cancer development. When infection is not detected at histology, another test is advised. EndoFaster is novel device that reveal the presence of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    by determining ammonium concentration in the gastric juice during endoscopy. We evaluated whether this test may improve etiological diagnosis in CAG patients. In 595 consecutive patients who underwent upper endoscopy gastric juice was analysed with EndoFaster and standard biopsies were taken. CAG with typical bacteria was detected in 102 (17.1%) patients, and CAG without\n                    <jats:italic>H. pylori<\/jats:italic>\n                    was found in 36 (6.3%) cases. EndoFaster detected the infection in 22 (61.1%) of these patients. Neither ongoing proton pump inhibitor therapy nor previous eradication therapy affect the test accuracy. By using EndoFaster, another test to search for the infection in\n                    <jats:italic>H. pylori<\/jats:italic>\n                    -negative CAG patients may be avoided in more than 60% of cases, impacting on both patients discomfort and health resources use.\n                  <\/jats:p>","DOI":"10.1136\/jclinpath-2021-207498","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T13:27:46Z","timestamp":1620739666000},"page":"572-574","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Real-time EndoFaster improves\n                    <i>Helicobacter pylori<\/i>\n                    detection in chronic active gastritis"],"prefix":"10.1136","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2329-8105","authenticated-orcid":false,"given":"Angelo","family":"Zullo","sequence":"first","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy, Presidio Territoriale di Prossimit\u00e0 Nuovo Regina Margherita, Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bastianello","family":"German\u00e0","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, San Martino Hospital, Belluno, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ermenegildo","family":"Galliani","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, San Martino Hospital, Belluno, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Iori","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy, Santa Chiara Hospital, Trento, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"De Pretis","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy, Santa Chiara Hospital, Trento, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Manfredi","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy, Maggiore Hospital Crema, Crema, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Buscarini","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy, Maggiore Hospital Crema, Crema, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Guarnieri","sequence":"additional","affiliation":[{"name":"Oncological Gastroenterology Unit, CRO, Aviano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Cannizzaro","sequence":"additional","affiliation":[{"name":"Oncological Gastroenterology Unit, CRO, Aviano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1102-701X","authenticated-orcid":false,"given":"Matteo Rossano","family":"Buonocore","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy, Ospedale di Cattinara, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Monica","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy, Ospedale di Cattinara, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,5,11]]},"reference":[{"key":"2025121219183620000_75.8.572.1","first-page":"6735","article-title":"Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention","volume":"52","author":"Correa","year":"1992","journal-title":"Cancer Res"},{"key":"2025121219183620000_75.8.572.2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"2025121219183620000_75.8.572.3","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312288"},{"key":"2025121219183620000_75.8.572.4","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i10.2232"},{"key":"2025121219183620000_75.8.572.5","article-title":"Diagnosis of Helicobacter pylori by invasive test: histology","volume":"3","author":"Lee","year":"2015","journal-title":"Ann Transl Med"},{"key":"2025121219183620000_75.8.572.6","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12333"},{"key":"2025121219183620000_75.8.572.7","doi-asserted-by":"publisher","DOI":"10.1177\/2050640615610021"},{"key":"2025121219183620000_75.8.572.8","first-page":"23","article-title":"Clinical validation of Endofaster\u00ae for a rapid diagnosis of Helicobacter pylori infection","volume":"112","author":"S\u00e1nchez Rodr\u00edguez","year":"2020","journal-title":"Rev Esp Enferm Dig"},{"key":"2025121219183620000_75.8.572.9","doi-asserted-by":"crossref","unstructured":"Zullo A , German B , Galliani E . 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