{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:47:52Z","timestamp":1792068472704,"version":"4.4.0"},"reference-count":20,"publisher":"BMJ","issue":"3","funder":[{"DOI":"10.13039\/100017981","name":"Sysmex","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100017981","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2021,9,22]]},"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Recently, a new automated digital cell imaging analyser (Sysmex CellaVision DC-1), intended for use in low-volume and small satellite laboratories, has become available. The purpose of this study was to compare the performance of the DC-1 with the Sysmex DI-60 system and the gold standard, manual microscopy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>White blood cell (WBC) differential counts in 100 normal and 100 abnormal peripheral blood smears were compared between the DC-1, the DI-60 and manual microscopy to establish accuracy, within-run imprecision, clinical sensitivity and specificity. Moreover, the agreement between precharacterisation and postcharacterisation of red blood cell (RBC) morphological abnormalities was determined for the DC-1.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>WBC preclassification and postclassification results of the DC-1 showed good correlation compared with DI-60 results and manual microscopy. In addition, the within-run SD of the DC-1 was below 1 for all five major WBC classes, indicating good reproducibility. Clinical sensitivity and specificity were, respectively, 96.7%\/95.9% compared with the DI-60% and 96.6%\/95.3% compared with manual microscopy. The overall agreement on RBC morphology between the precharacterisation and postcharacterisation results ranged from 49% (poikilocytosis) to 100% (hypochromasia, microcytosis and macrocytosis).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The DC-1 has proven to be an accurate digital cell imaging system for differential counting and morphological classification of WBCs and RBCs in peripheral blood smears. It is a compact and easily operated instrument that can offer low-volume and small satellite laboratories the possibilities of readily available blood cell analysis that can be stored and retrieved for consultation with remote locations.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jclinpath-2021-207863","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T13:29:45Z","timestamp":1633613385000},"page":"194-201","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Performance of the CellaVision DC-1 digital cell imaging analyser for differential counting and morphological classification of blood cells"],"prefix":"10.1136","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0698-5878","authenticated-orcid":false,"given":"Lisa N","family":"van der Vorm","sequence":"first","affiliation":[{"name":"Haematological Clinical Chemistry Laboratory, OLVG, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri\u00ebt A","family":"Hendriks","sequence":"additional","affiliation":[{"name":"OLVG Lab BV, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone M","family":"Smits","sequence":"additional","affiliation":[{"name":"OLVG Lab BV, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,10,7]]},"reference":[{"key":"2025092505355667000_76.3.194.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043442"},{"key":"2025092505355667000_76.3.194.2","doi-asserted-by":"publisher","DOI":"10.1309\/EK3C7CTDKNVPXVTN"},{"key":"2025092505355667000_76.3.194.3","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.035402"},{"key":"2025092505355667000_76.3.194.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-2712(03)00075-1"},{"key":"2025092505355667000_76.3.194.5","doi-asserted-by":"publisher","DOI":"10.29074\/ascls.27.1.32"},{"key":"2025092505355667000_76.3.194.6","first-page":"311","article-title":"Imprecision of ratio-derived differential leukocyte counts","volume":"11","author":"R\u00fcmke","year":"1985","journal-title":"Blood Cells"},{"key":"2025092505355667000_76.3.194.7","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.13042"},{"key":"2025092505355667000_76.3.194.8","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2013-201737"},{"key":"2025092505355667000_76.3.194.9","doi-asserted-by":"publisher","DOI":"10.4103\/2153-3539.151922"},{"key":"2025092505355667000_76.3.194.10","doi-asserted-by":"publisher","DOI":"10.1309\/XMB9K0J41LHLATAY"},{"key":"2025092505355667000_76.3.194.11","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2017-0132"},{"key":"2025092505355667000_76.3.194.12","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/ijlh.12832","article-title":"Optimizing morphology through blood cell image analysis","volume":"40 Suppl 1","author":"Merino","year":"2018","journal-title":"Int J Lab Hematol"},{"key":"2025092505355667000_76.3.194.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2014.10.005"},{"key":"2025092505355667000_76.3.194.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-2712(03)00076-3"},{"key":"2025092505355667000_76.3.194.15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1515\/cclm-2014-0445","article-title":"Performance evaluation of the digital cell imaging analyzer DI-60 integrated into the fully automated sysmex XN hematology analyzer system","volume":"53","author":"Tabe","year":"2015","journal-title":"Clin Chem Lab Med"},{"key":"2025092505355667000_76.3.194.16","unstructured":"Institute CaLS . Reference leukocyte differential count (proportional) and evaluation of instrumental methods; approved standard\u2014second edition. 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