{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T22:13:20Z","timestamp":1783808000860,"version":"3.55.0"},"reference-count":20,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2022,1,4]]},"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>We report on a Pashtun family affected by haemoglobin D-Punjab\/\u03b2+-thalassemia to increase the awareness of the increasing prevalence of haemoglobinopathies among primary care physicians. We highlight the diagnostic approach of these conditions and the benefits of genetic counselling.<\/jats:p>","DOI":"10.1136\/jclinpath-2021-208009","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T13:20:12Z","timestamp":1642425612000},"page":"861-864","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Diagnosis and clinical relevance of co-inheritance of haemoglobin D-Punjab\/\u03b2+-thalassemia traits in an immigrant Afghan family"],"prefix":"10.1136","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8803-9468","authenticated-orcid":false,"given":"Ralph","family":"Huits","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Institute of Tropical Medicine, Antwerpen, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Feyens","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Institute of Tropical Medicine, Antwerpen, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Lonneville","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Institute of Tropical Medicine, Antwerpen, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Peyrassol","sequence":"additional","affiliation":[{"name":"Service de G\u00e9n\u00e9tique\u2014Centre de G\u00e9n\u00e9tique humaine de l\u2019ULB, Universite Libre de Bruxelles, Bruxelles, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Sophie","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Universite Libre de Bruxelles, Bruxelles, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Gulbis","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Universite Libre de Bruxelles, Bruxelles, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Van Esbroeck","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Institute of Tropical Medicine, Antwerpen, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"key":"2025120619132969000_75.12.861.1","first-page":"532","article-title":"Hemoglobinopathies: clinical manifestations, diagnosis, and treatment","volume":"108","author":"Kohne","year":"2011","journal-title":"Dtsch \u00c4rzteblatt Int"},{"key":"2025120619132969000_75.12.861.2","unstructured":"Gulbis B , Ferster A , Vertongen F , et al . Hemoglobinopathies in Belgium. Belg J Hematol 2010:50\u20136."},{"key":"2025120619132969000_75.12.861.3","first-page":"704","article-title":"Inherited haemoglobin disorders: an increasing global health problem","volume":"79","author":"Weatherall","year":"2001","journal-title":"Bull World Health Organ"},{"key":"2025120619132969000_75.12.861.4","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/ijlh.12037","article-title":"Strategies for basic laboratory diagnostics of the hemoglobinopathies in multi-ethnic societies: interpretation of results and pitfalls","volume":"35","author":"Giordano","year":"2013","journal-title":"Int J Lab Hematol"},{"key":"2025120619132969000_75.12.861.5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4081\/thal.2014.1832","article-title":"HbA2 measurements in \u03b2-thalassemia and in other conditions","volume":"4","author":"Ivaldi","year":"2014","journal-title":"Thalassemia Reports"},{"key":"2025120619132969000_75.12.861.6","first-page":"823","article-title":"Effectiveness of red cell osmotic fragility test with varying degrees of saline concentration in detecting beta-thalassaemia trait","volume":"49","author":"Singh","year":"2008","journal-title":"Singapore Med J"},{"key":"2025120619132969000_75.12.861.7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.37.12.775"},{"key":"2025120619132969000_75.12.861.8","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.bjhh.2015.02.007","article-title":"Hemoglobin D-Punjab: origin, distribution and laboratory diagnosis","volume":"37","author":"Torres","year":"2015","journal-title":"Rev Bras Hematol Hemoter"},{"key":"2025120619132969000_75.12.861.9","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s00726-020-02858-9","article-title":"Effect of point mutation on structure-function correlation of hemoglobin variants, HbE and HbD Punjab","volume":"52","author":"Narayanan","year":"2020","journal-title":"Amino Acids"},{"key":"2025120619132969000_75.12.861.10","doi-asserted-by":"crossref","first-page":"90","DOI":"10.24018\/ejmed.2021.3.1.681","article-title":"Hemoglobin D-Punjab homozygotes and double heterozygotes in premarital screening: case presentations and minireview","volume":"3","author":"Denic","year":"2021","journal-title":"EJMED"},{"key":"2025120619132969000_75.12.861.11","first-page":"503","article-title":"\u03b2-thalassemia carriers in Afghanistan: a prevalence estimate","volume":"71","author":"Delacour","year":"2013","journal-title":"Ann Biol Clin"},{"key":"2025120619132969000_75.12.861.12","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s12687-010-0026-9","article-title":"A descriptive profile of \u03b2-thalassaemia mutations in India, Pakistan and Sri Lanka","volume":"1","author":"Black","year":"2010","journal-title":"J Community Genet"},{"key":"2025120619132969000_75.12.861.13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5223.1949.tb03339.x"},{"key":"2025120619132969000_75.12.861.14","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(12)70055-5"},{"key":"2025120619132969000_75.12.861.15","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1017\/S0021932011000253","article-title":"Consanguineous marriages in Afghanistan","volume":"44","author":"Saify","year":"2012","journal-title":"J Biosoc Sci"},{"key":"2025120619132969000_75.12.861.16","first-page":"61","article-title":"Co-Inheritance of hemoglobin D and \u03b2-thalassemia traits in three Iranian families: clinical relevance","volume":"14","author":"Taghavi Basmanj","year":"2011","journal-title":"Arch Iran Med"},{"key":"2025120619132969000_75.12.861.17","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.131"},{"key":"2025120619132969000_75.12.861.18","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1365-2141.2008.07071.x","article-title":"Is the beta thalassaemia trait of clinical importance?","volume":"141","author":"Premawardhena","year":"2008","journal-title":"Br J Haematol"},{"key":"2025120619132969000_75.12.861.19","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/bjh.15600","article-title":"Newborn screening for sickle cell disease in Europe: recommendations from a pan-European consensus conference","volume":"183","author":"Lobitz","year":"2018","journal-title":"Br J Haematol"},{"key":"2025120619132969000_75.12.861.20","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1515\/cclm-2015-0179","article-title":"Discriminant indices for distinguishing thalassemia and iron deficiency in patients with microcytic anemia: a meta-analysis","volume":"53","author":"Hoffmann","year":"2015","journal-title":"Clin Chem Lab Med"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2021-208009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:13:43Z","timestamp":1765077223000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2021-208009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,17]]},"references-count":20,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,11,17]]},"published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1136\/jclinpath-2021-208009"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2021-208009","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,17]]}}}