{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:39:53Z","timestamp":1763743193134,"version":"3.45.0"},"reference-count":10,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2021,12,14]]},"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background\/objectives<\/jats:title>\n                    <jats:p>Pathology laboratories are required to determine or estimate the measurement uncertainty for all quantitative results, but there is no literature on the uncertainty in margin measurements for skin cancer excisions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Six pathologists measured 4\u201314 histological margins in each of 10 basal cell carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean of measurements from all the margins from all the cases was 1.8\u2009mm (range 0 and 6\u2009mm). Regarding the overall variance in margin measurements across the ten cases, 25% was from variation within cases (differences in margin measurement for a given case, because of different margins and different pathologists measuring each margin, SD 0.7\u2009mm). For a given case, we estimate that 95% of margin measurements would fall approximately within\u00b11.4\u2009mm of the mean measurement for that case. When only pathologists\u2019 closest margin for each case were included (for the six cases with uninvolved margins), 6% of the overall variance was from differences within cases (because of different pathologists\u2019 measurements of the closest margin, SD 0.2\u2009mm). For a given case without an involved margin, 95% of closest margin measurements would fall approximately within\u00b10.5\u2009mm of the mean closest measurement for that case.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Clinicians should be aware there is uncertainty in reported histological margins.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2021-208030","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T13:27:38Z","timestamp":1640870858000},"page":"857-860","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["I need an exact margin measurement for this basal cell carcinoma!"],"prefix":"10.1136","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9751-5734","authenticated-orcid":false,"given":"Ian","family":"Katz","sequence":"first","affiliation":[{"name":"Southern Sun Pathology, Thornleigh, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Les","family":"Irwig","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"McGeehan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katy","family":"Bell","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,12,30]]},"reference":[{"key":"2025112108352238000_75.12.857.1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2010.0903"},{"key":"2025112108352238000_75.12.857.2","unstructured":"General requirements for the competence of testing and calibrating laboratories, ISO\/IEC 17025:2005, International Organization for Standardization (ISO)\/International Electrotechnical Comission (IEC) 2005."},{"key":"2025112108352238000_75.12.857.3","first-page":"S1","article-title":"Uncertainty of measurement in quantitative medical testing: a laboratory implementation guide","volume":"25","author":"White","year":"2004","journal-title":"Clin Biochem Rev"},{"key":"2025112108352238000_75.12.857.4","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13056"},{"key":"2025112108352238000_75.12.857.5","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12504"},{"key":"2025112108352238000_75.12.857.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1973.tb01915.x"},{"key":"2025112108352238000_75.12.857.7","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200104010-00006"},{"key":"2025112108352238000_75.12.857.8","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2019-205988"},{"key":"2025112108352238000_75.12.857.9","unstructured":"Howard V , Reid C , Cancer Council Australia Keratinocyte Cancers Guideline Working Party . Biopsy considerations and the biopsy report in: clinical practice guidelines for keratinocyte cancer. Available: https:\/\/wiki.cancer.org.au\/australia\/Guidelines:Keratinocyte_carcinoma\/Pathology_biopsy_report"},{"key":"2025112108352238000_75.12.857.10","unstructured":"Slater D , Barrett P . Dataset for histopathological reporting of primary cutaneous basal cell carcinoma: the Royal College of pathologists, 2019. Available: https:\/\/www.rcpath.org\/uploads\/assets\/53688094-791e-4aaa-82cec42c3cb65e35\/Dataset-for-histopathological-reporting-of-primary-cutaneous-basal-cell-carcinoma.pdf"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2021-208030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:35:31Z","timestamp":1763742931000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2021-208030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,30]]},"references-count":10,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,11,17]]},"published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1136\/jclinpath-2021-208030"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2021-208030","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[2021,12,30]]}}}