{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:02:02Z","timestamp":1793037722105,"version":"4.5.0"},"reference-count":32,"publisher":"BMJ","issue":"5","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901454"],"award-info":[{"award-number":["81901454"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"This research was funded by National Nature Science Foundation of China","award":["81701502"],"award-info":[{"award-number":["81701502"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2023,1,9]]},"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To stratify the risk of cervical precancers (high-grade squamous intraepithelial lesion (HSIL) and adenocarcinoma in situ (AIS)) and cancers (squamous cell carcinoma (SCC) and adenocarcinoma) based on distinct high-risk human papillomavirus (hrHPV) genotypes as well as age groups among women with atypical squamous cells of undetermined significance (ASC-US) and hrHPV+results.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In total, 2292 cases of ASC-US\/hrHPV+ with immediate follow-up biopsy results were included in the study for prevalence analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall, 12.2%\u2009women with ASC-US \/hrHPV+ had HSIL+ while 0.22% had AIS+ lesions. The HPV-16+ group (31.6%) showed significantly higher prevalence of HSIL+ squamous lesions than other genotype groups (p&lt;0.0001). The prevalence of SCC is significantly higher in HPV-16+ (1.8%) or HPV-18\/45+ (1.1%) group than women in other genotype groups (0.1%) (p&lt;0.0001). The HPV-18\/45+ group (1.7%) showed significantly higher prevalence of AIS+ glandular lesions than other genotype groups (p=0.003). In addition, SCC prevalence was significantly higher in age over 50 group than that in age under 50 group (1.2% vs 0.2%, p=0.012).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Women with ASC-US\/hrHPV+ are at significant risk of cervical precancers and cancers; notably, HPV-16+ group has a higher risk of HSIL squamous lesions and SCC while HPV-18\/45+ group has a higher risk of AIS+ glandular lesions. In addition, the older patient group (&gt;50 years) has a significantly higher risk of SCC. Therefore, HPV genotyping as well as patient age need to be considered in the clinical management of patient.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jcp-2022-208580","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T13:20:44Z","timestamp":1674048044000},"page":"338-342","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Correlation of immediate prevalence of cervical precancers and cancers with HPV genotype and age in women with ASC-US\/hrHPV+: a retrospective analysis of 2292 cases"],"prefix":"10.1136","volume":"77","author":[{"given":"Qin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pathology, Zhejiang University School of Medicine Women\u2019sHospital, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, 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