{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:48:05Z","timestamp":1792788485770,"version":"4.5.0"},"reference-count":58,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2023,7,30]]},"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>\n                    <jats:italic>FOS<\/jats:italic>\n                    and\n                    <jats:italic>FOSB<\/jats:italic>\n                    proto-oncogens are involved in a wide variety of tumourigenic processes.\n                    <jats:italic>FOS<\/jats:italic>\n                    and\n                    <jats:italic>FOSB<\/jats:italic>\n                    gene rearrangements are observed in epithelioid haemangioma, pseudomyogenic haemangioendothelioma, osteoid osteoma\/osteoblastoma\/cementoblastoma and proliferative myositis\/fasciitis. In this review, we provide an overview of\n                    <jats:italic>FOS<\/jats:italic>\n                    and\n                    <jats:italic>FOSB,<\/jats:italic>\n                    including their functions and the differences between lesions with known\n                    <jats:italic>FOS\/FOSB<\/jats:italic>\n                    gene rearrangements. Additionally, we discuss the use of\n                    <jats:italic>FOS<\/jats:italic>\n                    \/\n                    <jats:italic>FOSB<\/jats:italic>\n                    immunohistochemistry as a diagnostic tool for these lesions.\n                  <\/jats:p>","DOI":"10.1136\/jcp-2023-208931","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T13:25:35Z","timestamp":1691501135000},"page":"721-726","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":34,"title":["New kids on the block:\n                    <i>FOS<\/i>\n                    and\n                    <i>FOSB<\/i>\n                    gene"],"prefix":"10.1136","volume":"76","author":[{"given":"Fleur","family":"Cordier","sequence":"first","affiliation":[{"name":"Department of Pathology, Ghent University Hospital, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6064-1673","authenticated-orcid":false,"given":"David","family":"Creytens","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ghent University Hospital, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,8,8]]},"reference":[{"key":"2025112110195672000_76.11.721.1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204416"},{"key":"2025112110195672000_76.11.721.2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/cup.13141","article-title":"FOSB immunoreactivity in endothelia of epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia)","volume":"45","author":"Ortins-Pina","year":"2018","journal-title":"J Cutan Pathol"},{"key":"2025112110195672000_76.11.721.3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.18.5826"},{"key":"2025112110195672000_76.11.721.4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204385"},{"key":"2025112110195672000_76.11.721.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.08.008"},{"key":"2025112110195672000_76.11.721.6","doi-asserted-by":"publisher","DOI":"10.1042\/BST0360858"},{"key":"2025112110195672000_76.11.721.7","doi-asserted-by":"publisher","DOI":"10.14670\/HH-24.1451"},{"key":"2025112110195672000_76.11.721.8","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/16.5.985"},{"key":"2025112110195672000_76.11.721.9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C117.815845"},{"key":"2025112110195672000_76.11.721.10","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-04530-z","article-title":"Recurrent rearrangements of FOS and FOSB define osteoblastoma","volume":"9","author":"Fittall","year":"2018","journal-title":"Nat Commun"},{"key":"2025112110195672000_76.11.721.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00102-1"},{"key":"2025112110195672000_76.11.721.12","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.14.1.416"},{"key":"2025112110195672000_76.11.721.13","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22206"},{"key":"2025112110195672000_76.11.721.14","doi-asserted-by":"publisher","DOI":"10.1002\/path.4322"},{"key":"2025112110195672000_76.11.721.15","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201002111"},{"key":"2025112110195672000_76.11.721.16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.17.9671"},{"key":"2025112110195672000_76.11.721.17","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.217"},{"key":"2025112110195672000_76.11.721.18","doi-asserted-by":"crossref","DOI":"10.1186\/1750-1172-8-119","article-title":"A mutation in the C-Fos gene associated with congenital generalized lipodystrophy","volume":"8","author":"Knebel","year":"2013","journal-title":"Orphanet J Rare Dis"},{"key":"2025112110195672000_76.11.721.19","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2275"},{"key":"2025112110195672000_76.11.721.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.06.040"},{"key":"2025112110195672000_76.11.721.21","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000469"},{"key":"2025112110195672000_76.11.721.22","first-page":"1966","article-title":"Hemorrhagic epithelioid and spindle cell Hemangioma: a newly recognized, unique vascular tumor of bone","volume":"85","author":"Keel","year":"1999","journal-title":"Cancer"},{"key":"2025112110195672000_76.11.721.23","unstructured":"Antonescu C . 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