{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:38:23Z","timestamp":1787017103902,"version":"build-2736575974"},"reference-count":41,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2024,5,21]]},"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Little is known about the molecular features of visible polyps with low-grade intestinal-type dysplasia in patients with inflammatory bowel disease (IBD). To better understand their origins and biological potential, we sought to genomically profile these lesions and compare them with invisible low-grade dysplasia and sporadic adenomas from non-IBD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>22 polyps within areas of colitis, 13 polyps outside areas of colitis, 10 foci of invisible dysplasia from patients with IBD and 6 sporadic tubular adenomas from non-IBD patients were analysed using the OncoPanel assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Polyps arising in areas of colitis showed a greater spectrum of mutations, including\n                      <jats:italic>APC<\/jats:italic>\n                      ,\n                      <jats:italic>KRAS<\/jats:italic>\n                      ,\n                      <jats:italic>FBXW7<\/jats:italic>\n                      ,\n                      <jats:italic>TP53<\/jats:italic>\n                      ,\n                      <jats:italic>ARID1A<\/jats:italic>\n                      and\n                      <jats:italic>TCF7L2<\/jats:italic>\n                      . Polyps outside colitis and non-IBD sporadic adenomas showed a limited mutational profile, with\n                      <jats:italic>APC<\/jats:italic>\n                      and\n                      <jats:italic>CTNNB1<\/jats:italic>\n                      mutations. Invisible dysplasia was characterised by\n                      <jats:italic>TP53<\/jats:italic>\n                      ,\n                      <jats:italic>CTNNB1<\/jats:italic>\n                      and\n                      <jats:italic>KRAS<\/jats:italic>\n                      alterations. Compared with dysplastic polyps, none of the invisible dysplastic foci showed\n                      <jats:italic>APC<\/jats:italic>\n                      alterations (73%\u2014within colitis; p=0.0001, 92%\u2014outside colitis; p&lt;0.0001, 83%\u2014sporadic adenomas; p=0.001).\n                      <jats:italic>TP53<\/jats:italic>\n                      mutations were significantly higher in invisible dysplasia (50%) compared with polyps within colitis (9%; p=0.02) and outside colitis (8%; p=0.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Molecular alterations in visible low-grade dysplastic polyps with conventional intestinal-type dysplasia from patients with IBD and sporadic adenomas from non-IBD patients overlap significantly.\n                      <jats:italic>APC<\/jats:italic>\n                      alterations appear to play a major role in the development of visible low-grade dysplastic lesions in patients with IBD, regardless of background colitis. As with IBD-associated colorectal cancers,\n                      <jats:italic>TP53<\/jats:italic>\n                      mutations are an early event in the development of invisible, low-grade conventional intestinal-type dysplasia in patients with IBD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jcp-2024-209601","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T13:21:07Z","timestamp":1718630467000},"page":"416-425","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Molecular profiling of visible polypoid and invisible conventional intestinal-type low-grade dysplasia in patients with idiopathic inflammatory bowel disease"],"prefix":"10.1136","volume":"78","author":[{"given":"Alexander","family":"Christakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Nowak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R","family":"Goldblum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige","family":"Parrack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal I","family":"Lindeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Odze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7837-1299","authenticated-orcid":false,"given":"Deepa T","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,6,17]]},"reference":[{"key":"2025052523051489000_78.6.416.1","first-page":"2727","article-title":"Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies","volume":"29","author":"Triantafillidis","year":"2009","journal-title":"Anticancer Res"},{"key":"2025052523051489000_78.6.416.2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21505"},{"key":"2025052523051489000_78.6.416.3","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.65"},{"key":"2025052523051489000_78.6.416.4","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.12.036"},{"key":"2025052523051489000_78.6.416.5","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.04.001"},{"key":"2025052523051489000_78.6.416.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2019.04.013"},{"key":"2025052523051489000_78.6.416.7","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.01.031"},{"key":"2025052523051489000_78.6.416.8","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90008-Z"},{"key":"2025052523051489000_78.6.416.9","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.12.004"},{"key":"2025052523051489000_78.6.416.10","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90161-9"},{"key":"2025052523051489000_78.6.416.11","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91184-6"},{"key":"2025052523051489000_78.6.416.12","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90186-I"},{"key":"2025052523051489000_78.6.416.13","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.6.834"},{"key":"2025052523051489000_78.6.416.14","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz171"},{"key":"2025052523051489000_78.6.416.15","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i30.4148"},{"key":"2025052523051489000_78.6.416.16","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.06.001"},{"key":"2025052523051489000_78.6.416.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2023.05.008"},{"key":"2025052523051489000_78.6.416.18","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(83)80175-0"},{"key":"2025052523051489000_78.6.416.19","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.87062","article-title":"Institutional implementation of clinical tumor profiling on an Unselected cancer population","volume":"1","author":"Sholl","year":"2016","journal-title":"JCI Insight"},{"key":"2025052523051489000_78.6.416.20","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2016-0527-OA"},{"key":"2025052523051489000_78.6.416.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2016.07.010"},{"key":"2025052523051489000_78.6.416.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2014.11.004"},{"key":"2025052523051489000_78.6.416.23","doi-asserted-by":"publisher","DOI":"10.1038\/nature11252"},{"key":"2025052523051489000_78.6.416.24","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1403718"},{"key":"2025052523051489000_78.6.416.25","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90639-T"},{"key":"2025052523051489000_78.6.416.26","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70278-7"},{"key":"2025052523051489000_78.6.416.27","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70279-9"},{"key":"2025052523051489000_78.6.416.28","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90064-0"},{"key":"2025052523051489000_78.6.416.29","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200009000-00003"},{"key":"2025052523051489000_78.6.416.30","first-page":"2035","article-title":"Adenomatous Polyposis coli gene mutations in ulcerative colitis-associated Dysplasias and cancers versus sporadic colon Neoplasms","volume":"55","author":"Tarmin","year":"1995","journal-title":"Cancer Res"},{"key":"2025052523051489000_78.6.416.31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1999.tb00681.x"},{"key":"2025052523051489000_78.6.416.32","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90067-1"},{"key":"2025052523051489000_78.6.416.33","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)90222-2"},{"key":"2025052523051489000_78.6.416.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.036"},{"key":"2025052523051489000_78.6.416.35","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1856-1"},{"key":"2025052523051489000_78.6.416.36","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1844-5"},{"key":"2025052523051489000_78.6.416.37","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22867"},{"key":"2025052523051489000_78.6.416.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2023.01.009"},{"key":"2025052523051489000_78.6.416.39","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab120"},{"key":"2025052523051489000_78.6.416.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.12.009"},{"key":"2025052523051489000_78.6.416.41","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-316191"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp-2024-209601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T02:05:49Z","timestamp":1748225149000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp-2024-209601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,17]]},"references-count":41,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,5,25]]},"published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1136\/jcp-2024-209601"],"URL":"https:\/\/doi.org\/10.1136\/jcp-2024-209601","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,17]]}}}