{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T14:45:21Z","timestamp":1773931521122,"version":"3.50.1"},"reference-count":11,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2025,9,12]]},"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    is a well-established cause of gastritis and gastric malignancy, but other\n                    <jats:italic>Helicobacter<\/jats:italic>\n                    species\u2014collectively termed non-\n                    <jats:italic>Helicobacter pylori Helicobacter<\/jats:italic>\n                    (NHPH)\u2014also contribute to gastric disease. This study retrospectively analysed the prevalence of NHPH in 1115 routine gastric biopsies from a large academic medical centre submitted for\n                    <jats:italic>H. pylori<\/jats:italic>\n                    drug susceptibility genotyping using a next-generation sequencing (NGS) assay targeting\n                    <jats:italic>16S<\/jats:italic>\n                    and\n                    <jats:italic>23S<\/jats:italic>\n                    rRNA genes. NGS results of identified pathogens were compared against those identified on histology. NHPH species were detected in 15 of 1115 cases (1.3%), including 7 NHPH-only infections and 8 mixed infections with\n                    <jats:italic>H. pylori<\/jats:italic>\n                    . Detected NHPH species included\n                    <jats:italic>Helicobacter heilmannii<\/jats:italic>\n                    ,\n                    <jats:italic>Helicobacter felis<\/jats:italic>\n                    and\n                    <jats:italic>Helicobacter bizzozeronii<\/jats:italic>\n                    . No mutations associated with antimicrobial resistance were identified in NHPH. Broader molecular testing may improve recognition of mixed infections and guide more accurate diagnosis and treatment for gastric disease.\n                  <\/jats:p>","DOI":"10.1136\/jcp-2025-210346","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:25:33Z","timestamp":1758821133000},"page":"286-288","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of non-\n                    <i>Helicobacter pylori Helicobacter<\/i>\n                    (NHPH) species in\n                    <i>H. pylori<\/i>\n                    -associated gastritis"],"prefix":"10.1136","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7757-4462","authenticated-orcid":false,"given":"Yi Fan","family":"Chen","sequence":"first","affiliation":[{"name":"Pathology, University Hospitals Health System, Cleveland, Ohio, USA"},{"name":"Medical Scientist Training Program, Case Western Reserve University School of Medicine, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditi","family":"Tayal","sequence":"additional","affiliation":[{"name":"Pathology, University Hospitals Health System, Cleveland, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Friedman","sequence":"additional","affiliation":[{"name":"Pathology, Cleveland Clinic, Cleveland, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5051-717X","authenticated-orcid":false,"given":"Navid","family":"Sadri","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"2026031905050574000_79.4.286.1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-12-3"},{"key":"2026031905050574000_79.4.286.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2009.00535.x"},{"key":"2026031905050574000_79.4.286.3","doi-asserted-by":"crossref","DOI":"10.1111\/hel.12645","article-title":"Review: Other Helicobacter species","volume":"24 Suppl 1","author":"M\u00e9nard","year":"2019","journal-title":"Helicobacter"},{"key":"2026031905050574000_79.4.286.4","doi-asserted-by":"crossref","DOI":"10.1111\/hel.70051","article-title":"Roles of Gastric Non-Helicobacter pylori Helicobacter Species in Gastric Disease Development: A Review","volume":"30","author":"Sugimoto","year":"2025","journal-title":"Helicobacter"},{"key":"2026031905050574000_79.4.286.5","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.54.10.774"},{"key":"2026031905050574000_79.4.286.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2005.01844.x"},{"key":"2026031905050574000_79.4.286.7","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.4.1045-1048.1999"},{"key":"2026031905050574000_79.4.286.8","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.01834-18","article-title":"Helicobacter pylori Mutations Detected by Next-Generation Sequencing in Formalin-Fixed, Paraffin-Embedded Gastric Biopsy Specimens Are Associated with Treatment Failure","volume":"57","author":"Nezami","year":"2019","journal-title":"J Clin Microbiol"},{"key":"2026031905050574000_79.4.286.9","doi-asserted-by":"crossref","first-page":"360","DOI":"10.14309\/ajg.0000000000002085","article-title":"Tailored Treatment Based on Helicobacter pylori Genetic Markers of Resistance Is Associated With Higher Eradication Success","volume":"118","author":"Cummings","year":"2023","journal-title":"Am J Gastroenterol"},{"key":"2026031905050574000_79.4.286.10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3346\/jkms.2007.22.1.63","article-title":"Helicobacter heilmannii-associated gastritis: clinicopathologic findings and comparison with Helicobacter pylori-associated gastritis","volume":"22","author":"Joo","year":"2007","journal-title":"J Korean Med Sci"},{"key":"2026031905050574000_79.4.286.11","doi-asserted-by":"crossref","DOI":"10.3390\/jpm12020181","article-title":"Presence of Helicobacter Species in Gastric Mucosa of Human Patients and Outcome of Helicobacter Eradication Treatment","volume":"12","author":"Matos","year":"2022","journal-title":"J Pers Med"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp-2025-210346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:05:21Z","timestamp":1773921921000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp-2025-210346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,25]]},"references-count":11,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,3,19]]},"published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1136\/jcp-2025-210346"],"URL":"https:\/\/doi.org\/10.1136\/jcp-2025-210346","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,25]]}}}