{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:47:18Z","timestamp":1770504438838,"version":"3.49.0"},"reference-count":45,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1960,9]]},"abstract":"<jats:p>\n                    Five cases of aspergillosis complicating Hodgkin's disease and leukaemia are reported. The organs involved were: lungs (all five cases), stomach (Case 3); brain and meninges (Case 4); heart, kidneys, spleen, thyroid, and liver (Case 2). Cultures of\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    were obtained from the post-mortem tissues of three patients.\n                  <\/jats:p>\n                  <jats:p>All the lesions in Case 2 were suppurative. The other four cases had non-suppurative lesions characterized by spreading coagulation necrosis with peripheral hyperaemia, exudation, and haemorrhage. Invasion and occlusion of blood vessels occurred frequently.<\/jats:p>\n                  <jats:p>\n                    The various factors that may be responsible for the initiation and progression of the fungal infection are discussed. The available evidence suggests that\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    can produce toxic metabolites which are able to cause tissue necrosis and vascular damage. In patients suffering from neoplastic conditions of the lympho-reticular system, especially if steroid hormones or radiomimetic drugs are given, spreading, necrotizing lesions can develop unchecked by antibody or cellular defences.\n                  <\/jats:p>","DOI":"10.1136\/jcp.13.5.396","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"396-413","source":"Crossref","is-referenced-by-count":50,"title":["TISSUE REACTIONS TO ASPERGILLUS IN CASES OF HODGKIN'S DISEASE AND LEUKAEMIA"],"prefix":"10.1136","volume":"13","author":[{"given":"N. F. C.","family":"Gowing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris M. 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