{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:23:26Z","timestamp":1765729406900,"version":"3.48.0"},"reference-count":24,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1962,7]]},"abstract":"<jats:p>A family of mixed Indian-Portuguese ancestry is reported in which there is a hereditary persistence of foetal haemoglobin and \u03b2-chain thalassaemia.<\/jats:p>\n                  <jats:p>\n                    The propositus, a 17-year-old boy, was found to have a mild haemolytic anaemia characterized by slight splenomegaly, microcytosis, numerous target cells, decreased osmotic fragility, a very high level of foetal haemoglobin (75%), and normal haemoglobin A\n                    <jats:sub>2<\/jats:sub>\n                    level.\n                  <\/jats:p>\n                  <jats:p>\n                    Examination of 12 other members of the family showed the following: Three individuals (father, sister, and nephew) had high levels of foetal haemoglobin (25%) but without other clinical or haematological abnormalities. Two individuals (mother and sister) had the features of thalassaemia trait with increased haemoglobin A\n                    <jats:sub>2<\/jats:sub>\n                    and normal levels of foetal haemoglobin.\n                  <\/jats:p>\n                  <jats:p>The condition in the propositus appears to be the result of heterozygosity for a gene which is responsible for the hereditary persistence of foetal haemoglobin (high F gene) combined with heterozygosity for a \u03b2-thalassaemia gene and provides further evidence for allelism of these genes.<\/jats:p>\n                  <jats:p>The possible genetic basis for the high F state and \u03b2-chain thalassaemia is discussed.<\/jats:p>","DOI":"10.1136\/jcp.15.4.350","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"350-356","source":"Crossref","is-referenced-by-count":11,"title":["Observations on the high foetal haemoglobin gene and its interaction with the thalassaemia gene"],"prefix":"10.1136","volume":"15","author":[{"given":"P.","family":"Barkhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Adinolfi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1962,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1365-2141.1961.tb00327.x","volume":"7","author":"Beaven, G.H.; Ellis, M.J.; White, J.C.","year":"1961","unstructured":"Beaven, G. 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