{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:45:03Z","timestamp":1790419503854,"version":"4.1.0"},"reference-count":19,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1965,1]]},"abstract":"<jats:p>Serum haptoglobin has been estimated quantitatively in 25 patients with haemolytic disease, and its diagnostic value assessed by comparing the levels with those obtained in 110normal subjects, in 149 patients with other forms of anaemia, and in 37 patients with non-haematological disorders. The normal range was found to be 33 to 213 mg.\/100 ml.; subnormal levels were found in 80% of patients with haemolytic disease or megaloblastic anaemia, patients with haemorrhage into the tissues, and occasionally in association with other diseases. When taken in conjunction with other clinical and laboratory features this simple biochemical estimation can be of diagnostic value.<\/jats:p>","DOI":"10.1136\/jcp.18.1.114","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"114-118","source":"Crossref","is-referenced-by-count":28,"title":["Diagnostic value of serum haptoglobin"],"prefix":"10.1136","volume":"18","author":[{"given":"N. K.","family":"Shinton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. W.","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. D. F.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1965,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/181824a0","volume":"181","author":"Allison, A.C.; Blumberg, B.S.; Rees, Mrs","year":"1958","unstructured":"Allison, A. C., Blumberg, B. S., and Rees, Mrs. ap (1958). Nature (Lond.), 181, 824.","journal-title":"Nature (Lond.)"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3109\/00365516109137257","volume":"13","author":"Borglin, N.E.; Nyman, M.","year":"1961","unstructured":"Borglin, N. E., and Nyman, M. (1961). Scand. J. clin. Lab. Invest., 13, 107.","journal-title":"Scand. J. clin. Lab. Invest"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1365-2141.1959.tb04045.x","volume":"5","author":"Brus, I.; Lewis, S.M.","year":"1959","unstructured":"Brus, I., and Lewis, S. M. (1959). Brit. J. Haemat., 5, 348.","journal-title":"Brit. J. Haemat"},{"key":"ref_4","article-title":"Practical Haematology","author":"Dacie, J.V.; Lewis, S.M.","year":"1963","unstructured":"Dacie, J. V., and Lewis, S. M. (1963). Practical Haematology, 3rd ed. Churchill, London.","edition":"3rd ed"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000206522","volume":"25","author":"Ivanyi, J.; Sochman, J.; Ivanyi, P.","year":"1961","unstructured":"Ivanyi, J., Sochman, J., and Ivanyi, P. (1961). Acta haemat. (Basel), 25, 98.","journal-title":"Acta haemat. (Basel)"},{"key":"ref_6","first-page":"157","volume":"17","author":"Jayle, M.F.; Boussier, G.","year":"1955","unstructured":"Jayle, M. F., and Boussier, G. (1955). Expos. ann. Biochim. meid., 17, 157.","journal-title":"Expos. ann. Biochim. meid"},{"key":"ref_7","first-page":"21","volume":"21","author":"Mollison, P.L.","year":"1961","unstructured":"Mollison, P. L. (1961). Clin. Sci., 21, 21.","journal-title":"Clin. Sci"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1136\/jcp.11.3.206","volume":"11","author":"Neale, F.C.; Aber, G.M.; Northam, B.E.","year":"1958","unstructured":"Neale, F. C., Aber, G. M., and Northam, B. E. (1958). J. clin. Path., 11, 206.","journal-title":"J. clin. Path"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/S0140-6736(58)91804-X","volume":"1","author":"Nosslin, B.F.; Nyman, M.","year":"1958","unstructured":"Nosslin, B. F., and Nyman, M. (1958). Lancet, 1, 1000.","journal-title":"Lancet"},{"key":"ref_10","volume":"11","author":"Nyman, M.","year":"1959","unstructured":"Nyman, M. (1959). Scand. J. clin. Lab. Invest., 11, suppl.","journal-title":"Scand. J. clin. Lab. Invest"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1136\/jcp.13.2.163","volume":"13","author":"Owen, J.A.; Better, F.C.; Hoban, J.","year":"1960","unstructured":"Owen, J. A., Better, F. C., and Hoban, J. (1960). J. clin. Path., 13, 163.","journal-title":"J. clin. Path"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1136\/bmj.1.5135.1454","volume":"1","author":"Owen, J.A.; Better, F.C.; Hoban, J.; Mackay, I.R.; Got, C.","year":"1959","unstructured":"Owen, J. A., Better, F. C., and Hoban, J., Mackay, I. R., and Got, C. (1959). Brit. med. J., 1, 1454.","journal-title":"Brit. med. J"},{"key":"ref_13","first-page":"189","volume":"21","author":"Owen, J.A.; Better, F.C.; Hoban, J.; Mackay, I.R.; Got, C.; Padanyi, R.; Smith, H.","year":"1961","unstructured":"Owen, J. A., Better, F. C., and Hoban, J., Mackay, I. R., and Got, C., Padanyi, R., and Smith, H. (1961). Clin. Sci., 21, 189.","journal-title":"Clin. Sci"},{"key":"ref_14","first-page":"1","volume":"26","author":"Owen, J.A.; Better, F.C.; Hoban, J.; Mackay, I.R.; Got, C.; Padanyi, R.; Smith, H.; Smith, R.; Padanyi, R.; Martin, J.","year":"1964","unstructured":"Owen, J. A., Better, F. C., and Hoban, J., Mackay, I. R., and Got, C., Padanyi, R., and Smith, H., Smith, R., Padanyi, R., and Martin, J. (1964). Ibid., 26, 1. Pitcher, C. S., and Williams, R. (1963). Clin. Sci., 24, 239.","journal-title":"Ibid"},{"key":"ref_15","first-page":"66","volume":"21","author":"Polonovski, M.; Jayle, M.F.","year":"1939","unstructured":"Polonovski, M., and Jayle, M. F. (1939). Bull. Soc. Chim. biol. (Paris), 21, 66.","journal-title":"Bull. Soc. Chim. biol. (Paris)"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S0140-6736(63)92724-7","volume":"1","author":"Richardson, R.W.; Glick, S.; Bates, A.; Shinton, N.K.","year":"1963","unstructured":"Richardson, R. W., Glick, S., Bates, A., and Shinton, N. K. (1963). Lancet, 1, 608.","journal-title":"Lancet"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1042\/bj0610629","volume":"61","author":"Smithies, 0","year":"1955","unstructured":"Smithies, 0. (1955). Biochem. J., 61, 629.","journal-title":"Biochem. J"},{"key":"ref_18","article-title":"Radioisotope Techniques in Clinical Research and Diagnosis","author":"Veall, N.; Vetter, H.","year":"1958","unstructured":"Veall, N., and Vetter, H. (1958). Radioisotope Techniques in Clinical Research and Diagnosis. Butterworth, London."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1136\/gut.2.4.297","volume":"2","author":"Williams, R.; Speyer, B.E.; Billing, B.H.","year":"1961","unstructured":"Williams, R., Speyer, B. E., and Billing, B. H. (1961). Gut, 2, 297.","journal-title":"Gut"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.18.1.114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:25:54Z","timestamp":1765729554000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.18.1.114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1965,1]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1965,1,1]]},"published-print":{"date-parts":[[1965,1]]}},"alternative-id":["10.1136\/jcp.18.1.114"],"URL":"https:\/\/doi.org\/10.1136\/jcp.18.1.114","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1965,1]]}}}